PDF下载 ( 81 KB)
Relationship between tumor necrosis factor-α and lnsulin resistance in patients with liver cirrhosis
-
摘要: 为探讨肝硬化患者血清肿瘤坏死因子 -α（TNF -α）水平变化及与胰岛素抵抗 （IR）的关系。采用氧化酶法、放免法和酶联免疫法分别测定 2 3例肝硬化患者 （A组 ）、2 1例健康人 （B组 ）的空腹血糖 （FBG）、空腹胰岛素（FINS）及血清TNF -α值 ,并计算胰岛素敏感指数 （ISI）。A组FINS、TNF -α水平较B组显著增高 ,而ISI较B组显著降低。相关分析发现 ,TNF -α与ISI呈显著负相关 ,而与FINS呈显著正相关。肝硬化患者TNF -α水平增高 ,导致胰岛素抵抗产生 ,可能是肝硬化患者糖代谢紊乱的重要原因之一。Abstract: To investigate the changes of tumor necrosis factor-α (TNF-α) with liver cirrhosis and the relationship between TNF-α and insulin resistance (IR) , 23 liver cirrhosis (groupA) ; 21 health without liver cirrhosis (groupB) were selected to compare fasting blood-glucose (FBG) , fasting blood-insulin (FINS) and serum TNF-α by oxidase method, RIA and ELISA, Insulin sensitivity index (ISI) was also calculated. Analysis of variance revealed that FINS, TNF-α were significantly higher while ISI lover in group A than those in group B. Correlation analysis showed that TNF-α was negatively correlated to ISI, and positively associated with TNF-α and FINS. The study indicates that significantly hight level of TNF-α and IR play an important role in the liver cirrhosis and glucose metabolic disorder.
-
Key words:
- liver cirrhosis /
- tumor necrosis factor-α /
- insulin resistance
-
[1]KatsukiA , SumidaV , MurashimaS , etal.Serumlevelsoftumornecrosisfactor-alphaareincreasedinobesepatientswithnoninsulin-dependentdiabetesmellitus[J]JClinEndorinolMetab, 1998, 83∶859-862. [2]RavenGM .Roleofinsulinresistanceinhumandisease[J]Djabetes, 1988, 37∶1595-1607. [3]HotamisligilGS , PeraldiP , Budavari-A , etal.IRS -1-mediatedinhibitionofinsulinreceptortyrosinekinaseactivityinTNF -alpha-andobesity-inducedinsulinresistance[J]Science, 1996, 271∶665-668. [4] PazK , HemiR , LeroithD , etal.Amolecularbasisforinsulinre sistance.Elevatedserine/threoninephosphorylationofIRS -1andIRS -2inhibitstheirbindingtothejuxtamembraneregionofthein sulinreceptorandimpairstheirabilitytoundergoinsulin-inducedtyrosinephosphorylation[J]JBiolChem, 1997, 272∶29911-29916. [5] StephensJM , LeeJ, PilchPF .TNF -ainducedinsulinresistancein3T3-L1adipocytesisaccompaniedbyalossofinsulinreceptorsubstrate-1andGLUT4expressionwithoutalossofinsulinrecep tor-mediatedsignaltransduction[J]JBiolChem, 1997, 272∶971-976. [6]RodenM , PriceTB , PerseghinG , etal.Mechanismoffreefattyacid-inducedinsulinresistanceinhumans[J]JClinInvest, 1996, 97∶2859-2865. [7]HotamisligilGS , SpiegelmanBM .Tumornecrosisfactoralpha:akeycomponentoftheobesity-diabeteslink[J]Diabetes, 1994, 43∶1271-1278. -
本文二维码
计量
- 文章访问数: 2070
- HTML全文浏览量: 17
- PDF下载量: 742
- 被引次数: 0
下载:
