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乙肝后肝硬化患者血清IL-1β、TNF-α变化对骨代谢影响的临床研究
Clinical Study of Serum IL-1β、TNF-α on Bone Metabolism in Patients with Posthepatitic Cirrhosis
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摘要: 为探讨细胞因子对乙肝后肝硬化骨代谢的影响 ,采用RIA及ELISA分别测定 36例乙肝后肝硬化患者血清IL - 1β、TNF -α水平及骨密度测量 ,并与 15例健康者对照。结果表明 ,肝硬化患者血清IL - 1β、TNF -α水平较对照组显著升高 （P <0 0 0 1,P <0 0 0 1） ,其中骨质疏松 （OP）组较非骨质疏松 （NOP）组均升高明显 （P <0 0 0 1,P <0 0 1） ,且两组间Child -PughA、C级同级分别比较 ,血清IL - 1β水平显示差异 （P <0 0 1,P <0 0 5 ） ,血清TNF -α水平亦有差异 （P <0 0 5 ,P <0 0 5 ） ;OP组血清IL - 1β、TNF -α与尺桡密度均呈负相关 （r=0 6 38,P <0 0 1;r=0 483,P<0 0 5 ） ,而NOP组则呈无相关。提示乙肝后肝硬化患者血清IL - 1β、TNF -α水平升高 ,是肝性骨病 （HBD）发生的重要因素 ,降低体内IL - 1β、TNF -α水平...Abstract: To discuss the influence of cytokines on bone metabolism in patients with posthepatitic cirrhosis, levels of serum IL-1β、TNF-α were detected by radioimmunoassay and enzyme-linked immunosorbent assay respectively in 36 male cirrhosis and 15 age-matched healthy controls The result showed that serum IL-1β、TNF-α in cirrhosis increased more than that of controls (P<0 001, P<0 001) , and osteoporosis (OP) groups much higher than non-osteoporosis (NOP) groups (P<0 001, P<0 01) In Child-Pugh Class A and C, the levels of serum IL 1β ( P<0 05, P<0 01) and TNF-α (P<0 005, P<0 005) were significant difference between OP group and NOP group We also found IL-1β and TNF-α had negative correlation with mean ulnoradial density (r=0 638, P<0 01;r=0 438, P<0 05) It was suggested that elevation of serum IL-1β and TNF-α can accelerate bone resorption and lead to hepatic bone disease (HBD) Reducing the concentration and blocking the effect of IL-1β and TNF-α may be very important for prevention and treatment of HBD
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Key words:
- Interleukin-1β /
- Tumor necrosis factor-α /
- Hepatic bone disease
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