Objectives To analyze the clinical manifestation and influencing factors of drug-induced liver injury (DILI) , and to compare the accuracy of two diagnostic criteria CIOMS/RUCAM and Maria score.Methods Retrospective analysis was performed on 113 patients who have been diagnosed as drug-induced liver injury by liver biopsy in Ruijin hospital between July 2008 and November 2010.Age, sex, BMI, serological indicators, liver biopsy histologic changes, causes, clinical manifestation and prognoses were recorded.Results Among the 113 patients, 77 patients were female and 36 patients were male.The average age was 47.73±13.17.Chinese herbal medicine and diet tea were the main causes of DILI (48.67%) , followed by antibiotics, antipyretic analgesic anti-inflammatory drugs and cardiovascular drugs.The main symptoms were asthenia, nausea and epigastric discomfort.Classification: 47.79% of the patients were the injury type of hepatocytes, and most of them were female.The rest were the type of cholestasis and mix type.44.25% of the patients reached to normal liver function after 1 month treatment.Ishak fibrosis score (F) of the patients with the complication-AIH was high (P=0.015) .There were 7 cases (6.19%) falling into both histological activity index (HAI) ≥9 and F≥4, and 42.86% of them kept the liver function abnormal over half a year or died.CIOMS/RUCAM score≥6 and Maria score≥10 were 77.88% and 60.18%, respectively.Conclusion Chinese herbal medicine and diet tea were the main causes of DILI.Most of patients reinstated well after abandoning the medicine.Most of the hepatocytes type were female.The complication-AIH would influence over Ishak fibrosis score.Patients with HAI≥9 and F≥4 had poor prognosis.The sensitivity of RUCAM score was higher than Maria score.
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