中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2011

Value of autoantibodies in predicting autoimmune liver disease

Research funding:

 

  • Published Date: 2011-03-20
  • Autoantibodies have been widely used in autoimmune liver disease as diagnostic markers, but the value of estimating disease severity and prognosis has not been commonly comprehended.Actually, autoantibodies are valuable in predicting disease severity and treatment outcome as well as directing the diagnosis.Antibodies to soluble liver antigen, actin, liver cytosol type 1, asialoglycoprotein receptor, chromatin, cyclic citrullinated peptide, and uridine glucuronosyltransferases have been considered to be associated with the occurrence, severity and progression of autoimmune hepatitis.For example, antibody to soluble liver antigen is associated with severe histological changes, long durations of treatment, relapse after drug withdrawal and high frequency of liver failure.Besides, antibodies to Sp100, gp210 and centromere have prognostic value in primary biliary cirrhosis, for instance, antibody to gp210 is associated with severe interface hepatitis, lobular inflammation, and progression to liver failure.

     

  • [1]Luth S, Herkel J, Kanzler S, et al.Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis[J].J Clin Gastroenterol, 2008, 42 (8) :926-930.
    [2]Torres-Collado AX, Czaja AJ, Gelpi C.Anti-tRNP (ser) sec/SLA/LP autoantibodies.Comparative study using in-house ELISA with a recombinant 48.8 kDa protein, immunoblot, and analysis of immunoprecipitated RNAs[J].Liver Int, 2005, 25 (2) :410-419.
    [3]Klein R, Berg PA.Significance of antibodies to soluble liver/liver pancreas antigen:experiences in Germany[J].Liver Int, 2010, 30 (1) :155-156.
    [4]Czaja AJ, Donaldson PT, Lohse AW.Antibodies to soluble liver antigen/liver pancreas and HLA risk factors for type 1 autoimmune hepatitis[J].Am J Gastroenterol, 2002, 97 (2) :413-419.
    [5]Ma Y, Okamoto M, Thomas MG, et al.Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease[J].Hepatology, 2002, 35 (3) :658-664.
    [6]Gueguen P, Dalekos G, Nousbaum JB, et al.Double reactivity against actin and alpha-actinin defines a severe form of autoimmune hepatitis type 1[J].J Clin Immunol, 2006, 26 (6) :495-505.
    [7]Bridoux-Henno L, Maggiore G, Johanet C, et al.Features and outcome of autoimmune hepatitis type 2 presenting with isolated positivity for anti-liver cytosol antibody[J].Clin Gastroenterol Hepatol, 2004, 2 (9) :825-830.
    [8]Beland K, Lapierre P, Marceau G, et al.Anti-LC1 autoantibodies in patients with chronic hepatitis C virus infection[J].J Autoimmun, 2004, 22 (2) :159-166.
    [9]Kakegawa T, Ise H, Sugihara N, et al.Soluble asialoglycoprotein receptors reflect the apoptosis of hepatocytes[J].Cell Transplant, 2002, 11 (5) :407-415.J Clini Hepatol, March 2011, Vol.27, No.3
    [10]Hausdorf G, Roggenbuck D, Feist E, et al.Autoanti-bodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA--revival of a disease-activity marker in autoimmune hepatitis[J].Clin Chim Acta, 2009, 408 (1-2) :19-24.
    [11]El-Din Elshazly LB, Youssef AM, Mahmoud NH, et al.Study of nonstandard auto-antibodies as prognostic markers in auto immune hepatitis in children[J].Ital J Pediatr, 2009, 35 (1) :22.
    [12]Czaja AJ, Shums Z, Norman GL.Nonstandard antibodies as prognostic markers in autoimmune hepatitis[J].Autoimmunity, 2004, 37 (3) :195-201.
    [13]Montano-Loza A, Czaja AJ, Carpenter HA, et al.Frequency and significance of antibodies to cyclic citrullinated peptide in type 1 autoimmune hepatitis[J].Autoimmunity, 2006, 39 (4) :341-348.
    [14]Czaja AJ.Autoimmune liver disease[J].Curr Opin Gastroenterol, 2007, 23 (3) :255-262.
    [15]Csepregi A, Nemesánszky E, Luettig B, et al.LKM3 autoantibodies in hepatitis C cirrhosis:a further phenomenon of the HCV-induced autoimmunity[J].Am J Gastroenterol, 2001, 96 (3) :910-911.
    [16]Dalekos GN, Makri E, Loges S, et al.Increased inci-dence of anti-LKM autoantibodies in a consecutive cohort of hepatitis C patients from central Greece[J].Eur J Gastroenterol Hepatol, 2002, 14 (1) :35-42.
    [17]Muratori P, Muratori L, Gershwin ME, et al.'True'an-timitochondrial antibody-negative primary biliary cirrhosis, low sensitivity of the routine assays, or both?[J].Clin Exp Immunol, 2004, 135 (1) :154-158.
    [18]Shimoda S, Nakamura M, Ishibashi H, et al.Molecular mim-icry of mitochondrial and nuclear autoantigens in primary biliary cirrhosis[J].Gastroenterology, 2003, 124 (7) :1915-1925.
    [19]Bogdanos DP, Baum H, Butler P, et al.Association between the primary biliary cirrhosis specific anti-sp100 antibodies and recurrent urinary tract infection[J].Dig Liver Dis, 2003, 35 (11) :801-805.
    [20]Nakamura M, Kondo H, Mori T, et al.Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis[J].Hepatology, 2007, 45 (1) :118-127.
    [21]Muratori P, Muratori L, Ferrari R, et al.Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis[J].Am J Gastroenterol, 2003, 98 (2) :431-437.
    [22]周晔, 蒋天舒, 陈燕等.自身抗原gp210融合蛋白的重组表达及其临床应用研究[J].中华实验诊断学, 2007, 11 (6) :739-743.
    [23]Yang WH, Yu JH, Nakajima A, et al.Do antinuclear antibodies in primary biliary cirrhosis patients identify increased risk for liver failure[J].Clin Gastroenterol Hepatol, 2004, 2 (12) :1116-1122.
    [24]Assassi S, Fritzler MJ, Arnett FC, et al.Primary biliary cirrhosis (PBC) , PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patients[J].J Rheumatol, 2009, 36 (10) :2250-2256.
    [25]Lüth S, Herkel J, Kanzler S, et al.Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis[J].J Clin Gastroenterol, 2008, 42 (8) :926-930.
  • Relative Articles

    [1]Yuanjiao GAO, Yanjie LIN, Liu YANG, Xiaoyue BI, Wen DENG, Tingting JIANG, Fangfang SUN, Yao LU, Lu ZHANG, Minghui LI, Yao XIE. Liver histopathology and clinical features of autoimmune hepatitis with different antibody statuses[J]. Journal of Clinical Hepatology, 2022, 38(12): 2744-2749. doi: 10.3969/j.issn.1001-5256.2022.12.012
    [2]Fengxin CHEN, Zhan ZENG, Fangfang SUN, Leiping HU, Yao LU, Lu ZHANG, Minghui LI, XIE Yao. Clinical features and autoantibody characteristics of patients with drug-induced liver injury: An analysis of 419 cases[J]. Journal of Clinical Hepatology, 2022, 38(1): 148-153. doi: 10.3969/j.issn.1001-5256.2022.01.023
    [3]Jing CAI, Guiqin ZHOU, Yaxing LIU, Bin LI, Xiaojing WANG, Ying FENG, Xianbo WANG. Clinical features of Polygonum multiflorum preparation-related liver injury with or without positive autoantibody[J]. Journal of Clinical Hepatology, 2022, 38(10): 2296-2301. doi: 10.3969/j.issn.1001-5256.2022.10.018
    [4]Zhan WANG, Lin WANG, Yuan YAO, Jing LIU, Guirong SUN, Mingjun LIU. Value and clinical application of multiplex bead-based flow fluorescent immunoassay in the detection of autoantibodies in primary biliary cholangitis[J]. Journal of Clinical Hepatology, 2021, 37(10): 2384-2388. doi: 10.3969/j.issn.1001-5256.2021.10.025
    [5]Dang FuTao, Tang YingMei. Diagnostic and prognostic value of autoantibodies in primary biliary cholangitis[J]. Journal of Clinical Hepatology, 2020, 36(5): 1164-1166. doi: 10.3969/j.issn.1001-5256.2020.05.048
    [6]Zhang HaiPing, Yan HuiPing. Research advances in autoantibodies in autoimmune hepatitis[J]. Journal of Clinical Hepatology, 2020, 36(4): 749-753. doi: 10.3969/j.issn.1001-5256.2020.04.007
    [7]Han Ying, Chen Jie, Dan Jing, Liu YanMin, Zhang XiaoDan, Ren MeiXin, Du XiaoFei, Bian XinQu, Liu Dan, Huang YunLi, Huang ChunYang, Liao HuiYu. Value of fumarate hydratase antibody in differential diagnosis of autoimmune hepatitis and drug-induced liver injury[J]. Journal of Clinical Hepatology, 2019, 35(6): 1326-1329. doi: 10.3969/j.issn.1001-5256.2019.06.029
    [8]Xiao Qian, Tan ShanZhong, Zhao TianHui, Sun WeiWei, Shen JianJun, Liang ZhongFeng, Jiang ShuLian. Value of anti-nuclear antibody and liver pathology in diagnosis of male patients with autoimmune liver diseases[J]. Journal of Clinical Hepatology, 2019, 35(5): 1070-1073. doi: 10.3969/j.issn.1001-5256.2019.05.027
    [9]Xue Mei, Shen Yi, Shen MengYi, Fan XiaoLi, Men RuoTing, Yang Li. Autoimmune hepatitis-related autoantibodies and their clinical significance[J]. Journal of Clinical Hepatology, 2019, 35(6): 1392-1396. doi: 10.3969/j.issn.1001-5256.2019.06.048
    [10]Wu HuiLi, Zheng SuJun, Wang TaiLing, Yan HuiPing, Ren Feng, Li JunFeng, Chen Yu, Liu Mei, Liu Shuang, Duan ZhongPing. Pathological features of liver tissue in autoantibody-positive chronic hepatitis C patients after plasmaphoresis[J]. Journal of Clinical Hepatology, 2018, 34(2): 281-286. doi: 10.3969/j.issn.1001-5256.2018.02.013
    [11]Jiang HongLi, Qi YaBin, Zhang Rui, Hu YuLin. Detection rates of autoantibodies in patients with drug-induced liver injury and their clinical significance[J]. Journal of Clinical Hepatology, 2018, 34(1): 164-167. doi: 10.3969/j.issn.1001-5256.2018.01.034
    [12]Cao ZhangChun. Significance of combined analysis of autoantibodies in diagnosis of primary biliary cirrhosis[J]. Journal of Clinical Hepatology, 2015, 31(2): 178-180. doi: 10.3969/j.issn.1001-5256.2015.02.008
    [13]Liu YanMin. The clinical feature and prognosis in patients with drug induced liver injury complicated with positive autoantibodies detection[J]. Journal of Clinical Hepatology, 2012, 28(5): 335-338+342.
    [14]Yan HuiPing. Detection of autoantibodies and standardization of result report[J]. Journal of Clinical Hepatology, 2011, 27(6): 595-597.
    [15]Wang ChunYan, Hu DongSheng, Lu Wei. Detection and clinical significance of autoantibodies in patients with chronic hepatitis C in Tianjin[J]. Journal of Clinical Hepatology, 2011, 27(1): 93-95.
    [16]Zhang YanChao, Chen Ming, Chen Dan.

    Clinical significance of antibody profiling in autoimmune liver disease

    [J]. Journal of Clinical Hepatology, 2010, 26(3): 319-320.
    [17]Zhang ChunMing, Niu GuangHua, Qian ZhuShan. Detection and analysis of serum autoantibodies in patients with hepatitis C[J]. Journal of Clinical Hepatology, 2006, 22(2): 107-108.
    [18]Wang JingQuan, Cui ShiChang, Yan HuiPing, Dong ShengShan, Li DongCeng, Zhu RenPing. The clinical observation of autoantibody in autoimmune hepatitis[J]. Journal of Clinical Hepatology, 2004, 20(1): 12-13.
  • 加载中
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 4.5 %FULLTEXT: 4.5 %META: 90.7 %META: 90.7 %PDF: 4.8 %PDF: 4.8 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 2.4 %其他: 2.4 %China: 0.6 %China: 0.6 %[]: 0.3 %[]: 0.3 %上海: 1.8 %上海: 1.8 %东莞: 0.3 %东莞: 0.3 %北京: 6.9 %北京: 6.9 %南京: 0.3 %南京: 0.3 %南宁: 0.3 %南宁: 0.3 %台北: 0.3 %台北: 0.3 %台州: 0.3 %台州: 0.3 %吉林: 0.3 %吉林: 0.3 %圣彼得堡: 0.3 %圣彼得堡: 0.3 %墨尔本: 0.3 %墨尔本: 0.3 %张家口: 5.1 %张家口: 5.1 %成都: 0.6 %成都: 0.6 %昆明: 0.6 %昆明: 0.6 %武汉: 0.3 %武汉: 0.3 %深圳: 1.2 %深圳: 1.2 %舟山: 0.6 %舟山: 0.6 %芒廷维尤: 39.8 %芒廷维尤: 39.8 %莫斯科: 1.2 %莫斯科: 1.2 %襄阳: 0.3 %襄阳: 0.3 %西宁: 31.6 %西宁: 31.6 %邯郸: 0.3 %邯郸: 0.3 %长春: 3.9 %长春: 3.9 %其他China[]上海东莞北京南京南宁台北台州吉林圣彼得堡墨尔本张家口成都昆明武汉深圳舟山芒廷维尤莫斯科襄阳西宁邯郸长春

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (4261) PDF downloads(1220) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return