Expression of heme oxygenase in the kidney of experimental cirrhotic rat

Li TieHan; Tang Bo; Tang JiHong; Fu BiMang; Zhu Hong; Zhang Jie

Issue 3

Mar. 2011

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Article Navigation > Journal of Clinical Hepatology > 2011 > 27(3): 265-267

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Expression of heme oxygenase in the kidney of experimental cirrhotic rat

Published Date: 2011-03-20

Abstract

Abstract

Objective To observe and investigate the expression and significance of heme oxygenase-1 (HO-1) in the kidney of cirrhotic rat.Methods Liver cirrhosis models were induced by thioacetamide (TAA) .Pathological changes of the renal tissues were observed by HE stain and the changes and location of HO-1 were observed by immunohistochemistry.The quantitative analysis of changes in kidneys morphology and the expression level of HO-1 were measured by image analyzing system.Results Cirrhosis models were successfully constructed.HO-1 distribute mainly in renal tubular epithelial cells.The degree of the expression of HO-1 in cirrhotic rats was markedly higher than that of normal control group (P<0.01) .Conclusion The expression of HO-1 in the kidney of cirrhotic rat is greatly enhanced.The HO-1/CO system is probably involved in the pathogenesis of renal damage in hepatic cirrhosis.
- heme oxygenase (decyclizing) ,
- liver cirrhosis,
- experimental

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沈阳化工大学材料科学与工程学院沈阳 110142

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Expression of heme oxygenase in the kidney of experimental cirrhotic rat

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