The expression and clinical significance of resistance gene in hepatocellular carcinoma

Objective To detect the expression of three multidrug resistance genes (MDR1、MRP、GST-π) and evaluate clinical significances of multidrug resistance gene in hepatocellular carcinoma (HCC) .Methods RT-PCR was used to examine the expression of 3 resistance genes in 51 HCC cases and 10 normal tissues.Results The expression of MDR1、MRP、GST-π were 0.55±0.27, 0.62±0.29, 0.64±0.31 in hepatocellular cancer tissue and 0.23±0.10, 0.25±0.07, 0.26±0.12 in normal hepatic-tissue (P<0.05) .The expressions of MDR1、MRP、GST-π in HCC were higher in hepatocellular carcinoma tissue than those in normal tissue.The expression of multidrug resistance genes were positively related to tumor Edmondson grade (P<0.05) .The expression of MRP were correlated with the expression of GST-π.Conclusion Primary resistance existed in HCC and there were many mechanisms of multidrug resistance.MDR1, MRP, GST-π in hepatocellular carcinoma had a higher expression.Combined detection of LRP and GST-π expression maybe efficient in clinical treatment.