The influence of 5-hydroxytryptamine on rat with hepatic encephalopathy.

Song MinNing; Chen Fu; Song YuNa; Xie ZeJin

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Feb. 2008

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Article Navigation > Journal of Clinical Hepatology > 2008 > 24(2): 88-91

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五羟色胺对大鼠肝性脑病影响的研究

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Published Date: 2008-02-20

Abstract

Abstract

Objective To explore the influence of 5-hydroxytryptamine on rat with hepatic encephalopathy (HE) in stage of acute liver failures (ALF) .Methods Eighty Sprague-Dawley rats were divided into four groups randomly: Group A acted as control.Model of rat with HE were induced by 5% thioacetamide (TAA) intragastric administration in group B, C and D.Group B and C were given by 5-HT receptor blocking agent (Cyproheptadine) with 10 mg/kg and 20mg/kg respectively.Each group was detected by liver function tests, 5-HT, blood ammonia, serum endotoxin, brain magnetism resonance and histopathology.Results The level of 5-HT in group B, C and D were higher than those in normal control (t≥3.9, P<0.01) .The mortality in group B and C were both lower than that in group D (x2≥0.63, P<0.05) .The level of 5-HT at 72hour in group D was higher than that at 48-hour. (t=6.1, P<0.01) .The electron microscope showed that the neuron had swollen in groups B and C and marrow-like body had formed, whereas in group D, nerve cell were contracted and chromatin were hyperplasia, myeline sheath were edema and denaturation.Conclusion The level of 5-HT was increased obviously in rat with HE.The histological damage of brain has mitigated after administration with 5-HT receptor blocking agent and the mortality had cut down.
- rat,
- hepatic encephalopathy,
- 5-hydroxytryptamine,
- serotonin receptor,
- histopathology

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五羟色胺对大鼠肝性脑病影响的研究

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五羟色胺对大鼠肝性脑病影响的研究

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