To explore the relationship between Pre-S1 antigen (PreS1) and other hepatitis B virus (HBV) markers, HBV DNA.Pre-S1 antigen, HBV markers (HBVM) and HBV DNA in 916 serum samples were synchronously detected.The positive rates of Pre-S1 antigen, HBeAg and HBV DNA in the patient group are 77.09%, 59.78%, 65.36% respectively. The coincident rates of results are 72.63%, 74.72%, while they are all negative in control group. Among the three positive patterns with HBsAg, HBeAg, Anti-HBc or HBsAg, Anti-HBe, Anti-HBc and HBsAg, Anti-HBc, the coincident rate of Pre-S1 and HBV DNA were 90.42%、51.00%、and 53.41%.Compared the positive rates of Pre-S1 (91.59%、55.00%、56.82%) and those of HBV DNA (96.96%、17.00%、21.59%) , the differences were significant (all P<0.05) .The results suggested that Pre-S1 mainly exists in patients with HBsAg (+) , and has close relation with the condition of HBeAg and HBV DNA.So it is another dependable index to reflect the HBV replication and infective activity, the synchronous detection of Pre-S1 with HBV markers has its important clinical meaning.
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