The Effects of Daifansan on estrogen-induced intrahepatic cholestasis in rats

Cheng LiangBin; Zhao YouYun; Wang Hui; Kong Rui

Issue 6

Jun. 2003

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Article Navigation > Journal of Clinical Hepatology > 2003 > 19(6): 370-371

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黛矾散对雌激素诱导的大鼠肝内胆汁淤积的影响

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Published Date: 2003-06-20

Abstract

Abstract

To observe the effect of Daifansan and its components to rat's intrahepatic cholestasis induced by estradiol benzoate (EB) . Use EB to replicate cholestasis model and observe the effect of Daifansan and its component to the observing targets in serum, hepatic even cytoplasm and hypatocyte sub-membrane of the rats. In the model of cholestrasis caused by EB. TBA. TBil. ALT and ALP all go up distinctly (P<0.05) , but Tch goes down obviously (P<0.05) ;ALP in hepatic even cytoplasm and cholangiole membrane go up prominenty (P<0.05) ;the activity of Na +-K +-ATPase?Mg ++-ATPase all go down obviously (P<0.05) ;all the above changes are resulted from the Daifansan and it's components mingFan and QingDai to the different degree of the antagonism with the estrogen. The function of Daifansan is superior to that of mingFan or QingDai singly.
- Intrahepatic cholestasis,
- Estrogen,
- Daifansan

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References(6)

References

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沈阳化工大学材料科学与工程学院沈阳 110142

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黛矾散对雌激素诱导的大鼠肝内胆汁淤积的影响

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黛矾散对雌激素诱导的大鼠肝内胆汁淤积的影响

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