The expression and significance of chemokine interferon-inducible protein-10 (IP-10) in chronic hepatitis B patients

Shi LiYun; He JianQin; Chen Zhi; Wu LingJiao

Issue 4

Apr. 2003

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Article Navigation > Journal of Clinical Hepatology > 2003 > 19(4): 220-221

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趋化因子IP-10在慢性乙肝患者血清中的表达及意义

Published Date: 2003-04-20

Abstract

Abstract

To clarify the role of IP-10 in Chronic Hepatitis B, we study the serum levels of IP-10 in chronic hepatitis B patients and chronic severe hepatitis patients. The correlation between the serum levels of IP-10 and clinical parameters was also evaluated. The serum levels of IP-10 was much higher in patients with chronic hepatitis B than in healthy controls, and it was significantly correlated with ALT?AST. The results suggest that the serum levels of IP-10 can reflect the damage of hepatocytes.
- Chemokine,
- Interferon-inducible Protein-10 (IP-10) ,
- chronic hepatitis B

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[1]Loetscher M, Gerber B, Loetscher P. Chemokine receptor specific for IP-10 and Mig:structure, function, and expression in activated T-lymphocytes[J].J Exp Med, 1996, 184 (3) ∶963-9.

[2]Luster AD. Mechanisms of diseases:Chemokines-chemotactic cytokines that mediate inflammation[J].N Engl J Med, 1997, 338 (7) ∶436-443.

[3]Philip LS, Clare MM, Michael S, et al. Chemokine and Chemokine Receptor Interactions Provide a Mechanism for Selective T Cell Recruitment to Specific Liver Compartments Within Hepatitis C-Infected Liver[J]. J Immunol, 1999, 163 (11) ∶6236-6243.

[4]Kazuhiro K, Thomas EL, Stefan W, et al. Blocking chemokine responsive to γ-2/interferon (IFN) -γ inducible protein and monokine induced by IFN-γ activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T Lymphocytes[J].J Exp Med, 2001, 194 (12) ∶1755-66.

[5]Liu MT, Chen BP, Oertel P, et al. Cutting edge: the T cell chemoattractant IFN-inducible protein 10 (IP-10) is essential in host defense against viral-induced neurologic diseases[J].J Immunol, 2000, 165 (5) ∶2327-39.

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趋化因子IP-10在慢性乙肝患者血清中的表达及意义

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趋化因子IP-10在慢性乙肝患者血清中的表达及意义

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