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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 7
Jul.  2017
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Article Contents

Mechanism and significance of let-7 in diagnosis and treatment of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2017.07.039
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  • Received Date: 2017-02-27
  • Published Date: 2017-07-20
  • MicroRNA (miRNA) play important roles in post-transcriptional gene regulation.In recent years, miRNA has become a hot topic in the research on the development and progression of tumors, and gene targeting therapy for malignant tumors has achieved preliminary progress.As one of the first discovered miRNA, let-7 can regulate the cell cycle and angiogenesis and is involved in the proliferation, differentiation, and apoptosis of various tumor cells.Most members of the let-7 family can act as tumor suppressor gene and have low expression in various tumor tissues and high expression in the serum of patients with malignant tumors.Let-7 is closely associated with the invasion and drug resistance of hepatocellular carcinoma (HCC) .The studies above show that let-7 might become a new marker for the early diagnosis of HCC and provide new targets for the treatment of HCC.

     

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