2017 No. 7

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Editorial

Challenges in precise treatment for primary liver cancer based on gene mutation

Zhou HuaBang, Hu HePing

2017, 33(7): 1209-1210. DOI: 10.3969/j.issn.1001-5256.2017.07.001

Abstract(2712)

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Abstract:
Gene mutation is the molecular basis of the pathogenesis of primary liver cancer, and precise treatment based on gene mutation is an important direction for the treatment of liver cancer in future.This article introduces the current status, complexity, and prospects and future directions of precise ...

Value of contrast-enhanced ultrasound in early diagnosis of liver cancer and radiofrequency ablation treatment

Chen MinHua, Wu Wei

2017, 33(7): 1211-1213. DOI: 10.3969/j.issn.1001-5256.2017.07.002

Abstract(2584)

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Abstract:
Early identification and effective treatment of hepatocellular carcinoma plays an important role in improving survival rate.The establishment of simple and effective procedures for early diagnosis, census methods, and effective minimally invasive treatment is an important project in China to improve...

Therapeutic guidelines

Management algorithm for interrupting mother-to-child transmission of hepatitis B

Chinese Foundation for Hepatitis Prevention and Control; Chinese Society of Infectious Diseases, Chinese Medical Association; Chinese Society of Hepatology, Chinese Medical Association

2017, 33(7): 1214-1217. DOI: 10.3969/j.issn.1001-5256.2017.07.003

Abstract(4421)

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Abstract:

Expert consensus on transjugular intrahepatic portosystemic shunt

Interventional Group, Chinese Society of Radiology, Chinese Medical Association

2017, 33(7): 1218-1228. DOI: 10.3969/j.issn.1001-5256.2017.07.004

Abstract(3305)

PDF (1588KB)(677) Cited By (98)

Abstract:

Expert consensus on the classification of subtype in Budd-Chiari syndrome

Expert committee on Vane Cava Obstruction, Specialized Committee of Endovascology, Chinese Medical Doctor Association

2017, 33(7): 1229-1235. DOI: 10.3969/j.issn.1001-5256.2017.07.005

Abstract(3032)

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Abstract:

From 2012 to 2015 the Department of Interventional Radiology of the Affiliated Hospital of Xuzhou Medical University undertook the clinical special research subject” Study on the standardization of interventional diagnosis and treatment of Budd-Chiari syndrome” (No.BL2012021) , a program supported b...

Consensus on the clinical nutritional intervention for patients with chronic liver diseases

Beijing Medical Association, Committee of Parenteral and Enteral Nutrition;Expert Panel on Consensus on the parenteral and Enteral Nutritional and the Dietary Intervention for Patients with Chronic Liver Diseases

2017, 33(7): 1236-1245. DOI: 10.3969/j.issn.1001-5256.2017.07.006

Abstract(4433)

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Abstract:

Liver is the most important metabolic organ in the human body.The varying nutrient metabolism and malnutrition (undernutrition) occur in people with chronic liver diseases.Malnutrition and chronic liver damage are reciprocal causation, leading to form a vicious spiral.Whether nutritional support for...

An excerpt of medical management of severe alcoholic hepatitis: expert review from the clinical practice updates committee of the AGA institute (2017)

Zhu Ping, Han Tao

2017, 33(7): 1246-1248. DOI: 10.3969/j.issn.1001-5256.2017.07.007

Abstract(381)

PDF (169KB)(120) Cited By (5)

Abstract:

ACR appropriateness criteria resectable pancreatic cancer

Qi Bing, Shang Dong

2017, 33(7): 1249-1254. DOI: 10.3969/j.issn.1001-5256.2017.07.008

Abstract(290)

PDF (261KB)(119) Cited By (2)

Abstract:

An excerpt of 2016 consensus recommendations of the Korean Society of Abdominal Radiology about diagnosis of hepatocellular carcinoma with Gadoxetic Acid-enhanced MRI

Han Bing, Zhou Wei, Han Lei, Liu ZhangChun, Qi XingShun

2017, 33(7): 1255-1256. DOI: 10.3969/j.issn.1001-5256.2017.07.009

Abstract(308)

PDF (142KB)(54) Cited By (4)

Abstract:

Discussions by experts

Advances in early screening and diagnosis of hepatocellular carcinoma

Lu LunGen

2017, 33(7): 1257-1261. DOI: 10.3969/j.issn.1001-5256.2017.07.010

Abstract(3457)

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Abstract:
Hepatocellular carcinoma (HCC) is a malignant tumor with the second highest mortality rate in China, and annual deaths account for 51% of all deaths in the world.HCC brings heavy burdens to the society and medical care in China.Early diagnosis is one of the most important methods for preventing HCC ...

Serological diagnosis of hepatocellular carcinoma:challenges and opportunities

Lu FengMin

2017, 33(7): 1262-1265. DOI: 10.3969/j.issn.1001-5256.2017.07.011

Abstract(509)

PDF (214KB)(252) Cited By (32)

Abstract:
Serological markers have the features of noninvasiveness and simple operation and thus have become a research hotspot in the diagnosis of hepatocellular carcinoma.This article briefly introduces the role of the conventional serological marker alpha-fetoprotein (AFP) in assisting the diagnosis and pr...

Advances in imaging diagnosis of liver cancer

Zhang ChunYu, Fu Yu, Li XiaoDong, Li YongRui, Zhang HuiMao

2017, 33(7): 1266-1269. DOI: 10.3969/j.issn.1001-5256.2017.07.012

Abstract(2866)

PDF (1554KB)(543) Cited By (43)

Abstract:
Liver biopsy is the gold standard for the diagnosis of primary liver cancer, but it is an invasive examination.At present, imaging has become the preferred method for the diagnosis of liver cancer.This article summarizes new imaging methods and techniques for the diagnosis and evaluation of primary ...

Antiviral therapy for hepatitis virus-related hepatocellular carcinoma:current status and challenges

Dong Jing, Jiang JiaJi

2017, 33(7): 1270-1273. DOI: 10.3969/j.issn.1001-5256.2017.07.013

Abstract(2426)

PDF (1488KB)(489) Cited By (5)

Abstract:
The incidence rate of hepatocellular carcinoma (HCC) is increasing around the world and tends to decrease in East Asia and several regions in China;however, China still has higher incidence rate and mortality rate of HCC than most countries.Studies have shown that long-term antiviral therapy can inh...

Original articles_Viral hepatitis

Clinical value of hemoglobin and its association with hepatocyte steatosis in chronic hepatitis B patients

Wang Peng, Zhang ZhiQiao, Lu: GuoTao, Wang GongSui, Chen XiaoQiao, Ming Lang, Zheng Chong, Chen LeWu, Xie QiuLi, He JieXiong, Huang Yong

2017, 33(7): 1274-1279. DOI: 10.3969/j.issn.1001-5256.2017.07.014

Abstract(2549)

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Abstract:
Objective To investigate the clinical value of hemoglobin and its association with hepatocyte steatosis in chronic hepatitis B (CHB) patients.Methods A retrospective analysis was performed for the clinical and pathological data of 1580 CHB patients who were hospitalized in The First People's Hospita...

Establishment and functional evaluation of DC-CIK co-culture system with combined loading of HBsAg and HBcAg

Wang ShaoYang, Lin TaoFa, Zhu LingLing, Xie LiPing

2017, 33(7): 1280-1283. DOI: 10.3969/j.issn.1001-5256.2017.07.015

Abstract(2306)

PDF (1542KB)(406)

Abstract:
Objective To investigate the function of cytokine-induced killer cell (CIK) after co-culture of dendritic cells (DC) and CIK loaded with different HBV antigens.Methods A total of 13 patients with chronic hepatitis B (CHB) who visited Fuzhou General Hospital of Nanjing Military Area Command from Janu...

Original articles_Liver fibrosis and liver cirrhosis

Comparison of the abilities of five scoring systems to predict short-term and medium-term death risks in patients with decompensated cirrhosis

Fan XiaoLi, Wen MaoYao, Shen Yi, Yang Li

2017, 33(7): 1284-1290. DOI: 10.3969/j.issn.1001-5256.2017.07.016

Abstract(1706)

PDF (1744KB)(404) Cited By (24)

Abstract:
Objective To compare the abilities of Child-Turcotte-Pugh (CTP) score, Model for End-Stage Liver Disease (MELD) , MELD combined with serum sodium concentration (MELD-Na) , integrated MELD (iMELD) , and MELD to SNa ratio (MESO) to predict short-term and medium-term death risks in patients with decomp...

Original articles_Liver neoplasms

Value of combined detection of AFP, CA19-9, and CEA in early diagnosis of primary liver cancer

Li JiaYan, Song JinYun, Wang JianFang, Wu XuPing

2017, 33(7): 1291-1295. DOI: 10.3969/j.issn.1001-5256.2017.07.017

Abstract(3942)

PDF (1809KB)(562) Cited By (109)

Abstract:
Objective To investigate the value of combined measurement of alpha-fetoprotein (AFP) , carbohydrate antigen 19-9 (CA19-9) , and carcinoembryonic antigen (CEA) in the early diagnosis of primary liver cancer.Methods A total of 248 patients who visited the outpatient service or were hospitalized in Th...

Short-and long-term efficacy of transarterial chemoembolization versus liver resection in treatment of patients with Barcelona stage B multiple hepatocellular carcinoma

Li Xin

2017, 33(7): 1296-1300. DOI: 10.3969/j.issn.1001-5256.2017.07.018

Abstract(2392)

PDF (1574KB)(436) Cited By (3)

Abstract:
Objective To investigate the short-and long-term efficacy of transarterial chemoembolization (TACE) versus liver resection in the treatment of patients with Barcelona Clinic Liver Cancer (BCLC) stage B multiple hepatocellular carcinoma (HCC) .Methods A retrospective analysis was performed for the cl...

Shortening liver cancer screening interval may improve the prognosis of patients with hepatitis B cirrhosis-related hepatocellular carcinoma

Li Peng, Ding HuiGuo, Xu Hui, Zhang ShiBin, Zhang YueNing, Wang ZhenBiao, Wu YanJing, Yu HaiBin

2017, 33(7): 1301-1304. DOI: 10.3969/j.issn.1001-5256.2017.07.019

Abstract(2528)

PDF (1568KB)(425) Cited By (15)

Abstract:
Objective To investigate the influence of shortening liver cancer screening interval on the detection of early-stage hepatocellular carcinoma (HCC) in patients with hepatitis B cirrhosis and their prognosis, as well as proper screening schemes for such patients at a high risk of HCC.Methods A total ...

Influence of neutrophil-lymphocyte ratio on prognosis of liver cancer:a meta-analysis

Liu Jian, Gao ChiDan, Zhang LiXin, Quan Gang, Zhang YuShun, Li JingDong

2017, 33(7): 1305-1309. DOI: 10.3969/j.issn.1001-5256.2017.07.020

Abstract(2941)

PDF (1889KB)(440) Cited By (15)

Abstract:
Objective To investigate the association between neutrophil-lymphocyte ratio (NLR) and prognosis of liver cancer.Methods Pub Med, Embase and Cochrane Library, CBM, VIP, Wanfang Data were searched for Chinese and English articles on the association between NLR and prognosis of liver cancer published ...

Expression features and prognostic significance of Yes-associated protein in hepatocellular carcinoma and cholangiocellular carcinoma

Wang Chun, Wu Hao, Liu Yan, Ding Xiong, Li ZeMin

2017, 33(7): 1310-1315. DOI: 10.3969/j.issn.1001-5256.2017.07.021

Abstract(2435)

PDF (1789KB)(459) Cited By (4)

Abstract:
Objective To investigate the expression of Yes-associated protein (YAP) in hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CC) and its association with clinical prognosis.Methods Samples were collected from 190 patients who were treated in The Second Hospital Affiliated to Chongqing ...

Original articles_Biliary diseases

High-risk factors for cholangitis after endoscopic sphincterotomy

Zhang Yu

2017, 33(7): 1316-1319. DOI: 10.3969/j.issn.1001-5256.2017.07.022

Abstract(1916)

PDF (1497KB)(358) Cited By (5)

Abstract:
Objective To investigate the high-risk factors for cholangitis after endoscopic sphincterotomy (EST) , and to provide a reference for clinical prevention and treatment.Methods A total of 196 patients who underwent EST in our hospital from June 2013 to January2016 were enrolled, among whom 31 experie...

Original articles_Others

Clinical features of acute-on-chronic liver failure induced by withdrawal of nucleos (t) ide analogues

Hu GaoFei, Li XiaoPeng, Wu ZhenPing, Mei Qing, Li Dan, Zhang WenYuan, Yu TingTing, Cheng Na, Zhang LunLi

2017, 33(7): 1320-1323. DOI: 10.3969/j.issn.1001-5256.2017.07.023

Abstract(572)

PDF (226KB)(98) Cited By (11)

Abstract:

Objective To investigate the clinical features of patients with hepatitis B virus-related acute-on-chronic liver failure (ACLF) induced by the withdrawal of nucleos (t) ide analogues (NAs) .Methods A retrospective analysis was performed for the clinical data of 865 patients who were admitted to The ...

A preliminary investigation and feature analysis of non-alcoholic fatty liver and nonalcoholic steatohepatitis in employees in an IT company

Li XiuChi, Ruan GaiQing, LYU JiaEn, Sun MoQian, Wang MingMing

2017, 33(7): 1324-1327. DOI: 10.3969/j.issn.1001-5256.2017.07.024

Abstract(2598)

PDF (1498KB)(411) Cited By (9)

Abstract:

Objective To investigate the incidence rates and features of non-alcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) , and to provide a theoretical basis for health management and development of intervention and preventive measures in the health management department.Methods Physica...

Application of a modified diagnostic scale in diagnosis of acute drug-induced liver injury

Chou LiXia, Fan ZuoPeng, Liu Ying, Liang Shan, Nie Wei, Lin Wei, Liu YiRong, Zhang Jing, Hu ZhongJie

2017, 33(7): 1328-1331. DOI: 10.3969/j.issn.1001-5256.2017.07.025

Abstract(2470)

PDF (1780KB)(424) Cited By (4)

Abstract:

Objective To investigate the application of a modified diagnostic scale in the diagnosis of acute drug-induced liver injury (DILI) .Methods A total of 82 patients with acute DILI who were treated in Beijing You An Hospital, Capital Medical University from January 2011 to December 2015 were enrolled,...

Erythropoietic protoporphyria with jaundice as the main manifestation:a clinical, pathological, and genetic analysis of 4 cases

Li XiaoQing, Shi Jie, Lai YaMin, Zhang BoWei, Wu LiNa, Zhu LiMing, Zhang Tao, Qian JiaMing

2017, 33(7): 1332-1335. DOI: 10.3969/j.issn.1001-5256.2017.07.026

Abstract(2453)

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Abstract:

Objective To investigate the clinical, pathological, and genetic features of erythropoietic protoporphyria, and to enhance the knowledge of liver involvement in this disease.Methods A retrospective analysis was performed for the clinical data of 4 patients with erythropoietic protoporphyria with jau...

Characteristics and clinical significance of peripheral follicular cytotoxic T cells in patients experiencing acute rejection after liver transplantation

Zhang Ke, Yang Fan, Sun YanLing, Liu ZhenWen, Wang FuSheng, Shi Ming

2017, 33(7): 1336-1339. DOI: 10.3969/j.issn.1001-5256.2017.07.027

Abstract(2462)

PDF (1744KB)(396) Cited By (1)

Abstract:

Objective To investigate the expression characteristics of peripheral follicular cytotoxic T (Tfc) cells in patients undergoing liver transplantation and their significance in acute rejection.Methods A total of 36 patients who underwent liver transplantation in Liver Transplantation Research Center ...

Brief reports

Diagnosis and interventional therapy for Budd-Chiari syndrome secondary to hepatic venous obstruction

Yu Hong, Sun DianXing, Liang ZhiHui, Li HaiJun, Yang XinYing, Kang FuBiao

2017, 33(7): 1340-1341. DOI: 10.3969/j.issn.1001-5256.2017.07.028

Abstract(1952)

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Abstract:

Case reports

A case of adult huge undifferentiated sarcoma of the liver

Kou Kai, Sun DaWei, Liu Huan, Zhou JianPeng, Wang GuangYi, Lu: GuoYue

2017, 33(7): 1342-1343. DOI: 10.3969/j.issn.1001-5256.2017.07.029

Abstract(296)

PDF (282KB)(52) Cited By (1)

Abstract:

Intractable hypokalemia caused by glycyrrhizinic acid preparations:a case report

Pang XiangJun, Zhao Na, Wang ShouQing, Xin GuiJie

2017, 33(7): 1344-1345. DOI: 10.3969/j.issn.1001-5256.2017.07.030

Abstract(2100)

PDF (1469KB)(496) Cited By (5)

Abstract:

Common bile duct wall puncture and biopsy guided by endoscopic ultrasonography in diagnosis of common bile duct malignant tumor:a case report

Wen HongXu, Xue DiQiang, Du HongWei, Ming YuZhen

2017, 33(7): 1346-1348. DOI: 10.3969/j.issn.1001-5256.2017.07.031

Abstract(1753)

PDF (1812KB)(351)

Abstract:

Reviews

Research advances in influencing factors for the antiviral effect of nucleos (t) ide analogues

Wang LiLi, Liang YueDong

2017, 33(7): 1349-1353. DOI: 10.3969/j.issn.1001-5256.2017.07.032

Abstract(627)

PDF (262KB)(173) Cited By (7)

Abstract:
Nucleos (t) ide analogues (NAs) have been widely used in clinical practice as first-line antiviral drugs.In recent years, many clinical studies have found that some patients cannot reach a satisfactory therapeutic outcome.This article introduces the antiviral indications and follow-up of chronic hep...

Influence of maintained hemodialysis on viral load in patients with end-stage renal disease with HBV infection

Zhang HuiFang, Li YongGuo

2017, 33(7): 1354-1357. DOI: 10.3969/j.issn.1001-5256.2017.07.033

Abstract(1227)

PDF (1501KB)(351) Cited By (1)

Abstract:
In the patients with end-stage renal disease (ESRD) with hepatitis B virus (HBV) infection who underwent hemodialysis, the viral load of HBV DNA is relatively low and stable.For this phenomenon, some studies suggest that hemodialysis can reduce the HBV DNA load.The mechanism, which remains unclear, ...

Research advances in radiofrequency ablation in treatment of hepatocellular carcinoma

Luo DanDong, Qiao AnYi

2017, 33(7): 1358-1361. DOI: 10.3969/j.issn.1001-5256.2017.07.034

Abstract(1925)

PDF (1499KB)(419) Cited By (6)

Abstract:
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death in the world, and only 20% of HCC patients can undergo radical treatment.Radiofrequency ablation induces coagulative necrosis of cells via thermal energy, kills tumor cells, and makes it possible to cure HCC.Many...

Current status of treatment of liver cancer complicated by esophageal variceal bleeding

Peng Zhong, Qi XingShun, Guo XiaoZhong

2017, 33(7): 1362-1364. DOI: 10.3969/j.issn.1001-5256.2017.07.035

Abstract(1639)

PDF (1478KB)(396) Cited By (2)

Abstract:
Esophageal variceal bleeding is a major complication of liver cancer and a major cause of death in patients with liver cancer.This article summarizes the current status of the treatment of liver cancer complicated by esophageal variceal bleeding, including drugs and endoscopic and interventional tre...

Clinical application of positron emission tomography/computed tomography in hepatocellular carcinoma and related research advances

Zhang ZeYu, Cheng HongYan

2017, 33(7): 1365-1368. DOI: doi:10.3969/j.issn.1001-5256.2017.07.036

Abstract(1545)

PDF (1501KB)(413) Cited By (13)

Abstract:

Advances in the application of GPC3 in treatment of liver cancer

Ren ZhiZhong, Zhang YueWei

2017, 33(7): 1369-1372. DOI: 10.3969/j.issn.1001-5256.2017.07.037

Abstract(2109)

PDF (1503KB)(458) Cited By (1)

Abstract:
Liver cancer is one of the most common malignant tumors in the world, and traditional liver cancer treatment methods have their own limitations.Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan and is involved in the regulation of individual development and cell proliferation and diff...

Role of cell apoptosis regulated by P53 in treatment of hepatocellular carcinoma

Gao Si, Zhao XiangXuan, Lu ZaiMing

2017, 33(7): 1373-1376. DOI: 10.3969/j.issn.1001-5256.2017.07.038

Abstract(2359)

PDF (1502KB)(427) Cited By (13)

Abstract:
P53 abnormality or mutation is commonly seen in patients with hepatocellular carcinoma (HCC) , and therefore, restoration of P53 function has become a research hotspot in the treatment of HCC.This article reviews the association of P53 with Bcl-2 protein family, microRNA, TGFβ, HBV, HCV, and AKT and...

Mechanism and significance of let-7 in diagnosis and treatment of hepatocellular carcinoma

Huo TingTing, Wang DongXu, Zhang MingZhi, Zhao Lei

2017, 33(7): 1377-1380. DOI: 10.3969/j.issn.1001-5256.2017.07.039

Abstract(2388)

PDF (1498KB)(420)

Abstract:
MicroRNA (miRNA) play important roles in post-transcriptional gene regulation.In recent years, miRNA has become a hot topic in the research on the development and progression of tumors, and gene targeting therapy for malignant tumors has achieved preliminary progress.As one of the first discovered m...

Pathogenesis of hepatocellular carcinoma induced by HBV and HCV infection

Wang YueJiao, Song HaiYan, Xing LianJun, Ji Guang, Zheng PeiYong

2017, 33(7): 1381-1386. DOI: 10.3969/j.issn.1001-5256.2017.07.040

Abstract(2608)

PDF (1530KB)(492) Cited By (5)

Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide.Surgery is the preferred therapy for patients with small HCC;however, there still lack effective therapies for advanced HCC and postoperative recurrence and metastasis, leading to its high mortality.Persistent hepati...

Research advances in immune repertoire and high-throughput sequencing in primary biliary cholangitis

Zhao DanTong, Guo ChangLong, Yan HuiPing

2017, 33(7): 1387-1390. DOI: 10.3969/j.issn.1001-5256.2017.07.041

Abstract(2426)

PDF (1496KB)(459) Cited By (3)

Abstract:
Primary biliary cholangitis (PBC) is an autoimmune liver disease with unclear pathogenesis.The amino acid composition and sequence in the complementarity-determining region 3 of T cell receptor (TCR) and B cell receptor (BCR) are highly diverse, which forms a large antigen recognition receptor reper...

Latest advances in diagnosis and treatment of occult common bile duct stones

Wang Chao, Xu Feng, Liu XiaoLin, Dai ChaoLiu

2017, 33(7): 1391-1396. DOI: 10.3969/j.issn.1001-5256.2017.07.042

Abstract(785)

PDF (299KB)(207) Cited By (36)

Abstract:
Occult common bile duct stones have no clinical symptoms and if it is not diagnosed or treated in time, it can cause unexplained abdominal pain after cholecystectomy or serious complications such as biliary pancreatitis and acute cholangitis, which may threaten patients' lives.Proper diagnosis and t...

Clinical application of hepatopancreatoduodenectomy in treatment of advanced gallbladder cancer

Zhang HaiWen, Wang Meng, Wang ChuanLei, Jie EnBo, Wang GuangYi

2017, 33(7): 1397-1399. DOI: 10.3969/j.issn.1001-5256.2017.07.043

Abstract(2131)

PDF (1479KB)(475) Cited By (5)

Abstract:
Gallbladder cancer has many characteristics such as rapid progression, difficult early diagnosis, low R0 resection rate, and poor prognosis.In recent years, extended radical resections including hepatopancreatoduodenectomy (HPD) have been performed for patients with advanced gallbladder carcinoma th...