Research progress in mechanism of coexistence of HBsAg and HBsAb in patients with HBV infection

Ren MeiXin; Meng QingHua

doi:10.3969/j.issn.1001-5256.2014.04.023

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Apr. 2014

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Article Navigation > Journal of Clinical Hepatology > 2014 > 30(4): 375-378

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Research progress in mechanism of coexistence of HBsAg and HBsAb in patients with HBV infection

DOI: 10.3969/j.issn.1001-5256.2014.04.023

Department of Severe Liver Disease, Beijing Youan Hospital, Capital Medical University

Published Date: 2014-04-20

Abstract

Abstract

Hepatitis B surface antibody (HBsAb) is formed in response to hepatitic B virus (HBV) infection, which is a typical characteristic of virus clearance.It is theoretically impossible to detect sequential expression of hepatitis B surface antigen (HBsAg) and HBsAb in the same patient.In recent years, however, cases of coexistence of HBsAg and HBsAb have been frequently reported.Clinically, coexistence of HBsAg and HBsAb is commonly seen in patients with chronic hepatitis B and those injected with hepatitis B vaccine or given high-dose monoclonal anti- HBs.The mechanism of this special phenomenon remains unclear.The relevant research findings in China and the rest of the world are summarized.Analysis shows that coexistence of HBsAg and HBsAb may be related to HBV S gene mutation, decreased binding force of HBsAb, etc.
- hepatitis B, chronic,
- hepatitis B surface antigens,
- review

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References(42)

References

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Research progress in mechanism of coexistence of HBsAg and HBsAb in patients with HBV infection

DOI: 10.3969/j.issn.1001-5256.2014.04.023

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Research progress in mechanism of coexistence of HBsAg and HBsAb in patients with HBV infection

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