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Volume 42 Issue 7
Jul.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(7): 1730-1737

Mechanism of action of adipose tissue-derived extracellular vesicles in liver diseases

DOI: 10.12449/JCH260734

  • Laboratory of Gastrointestinal Cancer and Liver Disease，West China Hospital，Sichuan University，Chengdu 610000，China

Research funding:

West China Hospital “Venus” Young Talent Research Start-up Grant (HXQMX0010)

More Information
  • Corresponding author: Zhou Leyu， zhouleyu@scu.edu.cn （ORCID： 0000-0001-5421-4117）
  • Received Date: 2025-11-22
  • Accepted Date: 2026-01-04
  • Published Date: 2026-07-25
    Abstract
  • Adipose tissue is a crucial endocrine and immune organ， and its functional dysregulation is closely associated with the development and progression of various liver diseases. In addition to the secretion of classical adipokines， adipose tissue-derived extracellular vesicles （EVs） have emerged as key messengers in its regulation of distal organ function. This review systematically elaborates on the regulatory role of adipose tissue-derived EVs in liver diseases， in which white adipose tissue delivers pathogenic molecules such as miR-103 and CD36 via its EVs and thus drives hepatic insulin resistance， lipid accumulation， and fibrosis， while brown adipose tissue transmits protective signals such as miR-132-3p through its EVs to improve hepatic metabolic homeostasis. This article also summarizes the core mechanisms of action of these EVs and discusses their potential as diagnostic biomarkers and innovative therapeutic strategies.

     

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