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CN 22-1108/R
Volume 42 Issue 7
Jul.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(7): 1656-1660

Clinical and pathological features of intrahepatic intraductal papillary neoplasm of the bile duct: An analysis of four cases

DOI: 10.12449/JCH260723
  • 1.

    Department of Pathology，Beijing Chaoyang Hospital，Capital Medical University，Beijing 100020，China

  • 2.

    Department of Minimally Invasive Hepatobiliary Surgery，Chuiyangliu Hospital Affiliated to Tsinghua University，Beijing 100022，China

More Information
  • Corresponding author: Jia Fan， jiafanemail@163.com （ORCID： 0000-0002-3128-8778）; Zhang Yungang， ygzhang91@163.com （ORCID： 0009-0001-9236-4842）
  • Received Date: 2026-01-09
  • Accepted Date: 2026-04-27
  • Published Date: 2026-07-25
    Abstract
  •   Objective  To investigate the clinical and pathological features of intrahepatic intraductal papillary neoplasm of the bile duct （IPNB）， and to improve the understanding， diagnosis， and treatment of this disease.  Methods  A retrospective analysis was performed for four patients who underwent surgical resection in Beijing Chaoyang Hospital， Capital Medical University， from January 2010 to December 2025 and were diagnosed with intrahepatic IPNB based on pathological examination. The clinical， imaging， and pathological features of these patients were summarized， and a literature review was performed for related articles in China and globally.  Results  Among the four patients， there were three female patients and one male patient， with a median age of 65 years， and clinical manifestations included jaundice， abdominal pain or diarrhea， and asymptomatic findings on physical examination. The main imaging manifestation was bile duct dilatation or solid-cystic space-occupying lesion. Pathological typing revealed one case each of the gastric， intestinal， pancreatobiliary， and oncocytic types， and there was one patient with low-grade intraepithelial neoplasia and three patients with high-grade intraepithelial neoplasia， among whom one patient also had invasive carcinoma.  Conclusion  Intrahepatic IPNB is a rare precancerous lesion of the liver with diverse clinical， imaging， and pathological manifestations， and radical surgical resection remains the cornerstone of treatment.

     

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  • [1]
    Fléjou J F. Classification OMS 2010 des tumeurs digestives: La quatrième édition[J]. Ann De Pathol, 2011, 31( 5): S27- S31. DOI: 10.1016/j.annpat.2011.08.001.
    [2]
    Nagtegaal I D, Odze R D, Klimstra D, et al. The 2019 WHO classification of tumours of the digestive system[J]. Histopathology, 2020, 76( 2): 182- 188. DOI: 10.1111/his.13975.
    [3]
    Rocha F G, Lee H, Katabi N, et al. Intraductal papillary neoplasm of the bile duct: A biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas?[J]. Hepatology, 2012, 56( 4): 1352- 1360. DOI: 10.1002/hep.25786.
    [4]
    Youn J M, Hwang S, Ahn C S, et al. Clinicopathological features and long-term outcomes of intraductal papillary neoplasms of the bile duct of the liver: Single-institution experience with 146 patients[J]. J Gastrointest Surg, 2022, 26( 7): 1394- 1405. DOI: 10.1007/s11605-022-05268-2.
    [5]
    Aoki Y, Mizuma M, Hata T, et al. Intraductal papillary neoplasms of the bile duct consist of two distinct types specifically associated with clinicopathological features and molecular phenotypes[J]. J Pathol, 2020, 251( 1): 38- 48. DOI: 10.1002/path.5398.
    [6]
    Nakanuma Y, Uesaka K, Kakuda Y, et al. Intraductal papillary neoplasm of bile duct: Updated clinicopathological characteristics and molecular and genetic alterations[J]. J Clin Med, 2020, 9( 12): 3991. DOI: 10.3390/jcm9123991.
    [7]
    Nakanuma Y, Jang K T, Fukushima N, et al. A statement by the Japan-Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage[J]. J Hepato Biliary Pancreat Sci, 2018, 25( 3): 181- 187. DOI: 10.1002/jhbp.532.
    [8]
    Kubota K, Jang J Y, Nakanuma Y, et al. Clinicopathological characteristics of intraductal papillary neoplasm of the bile duct: A Japan-Korea collaborative study[J]. J Hepato Biliary Pancreat Sci, 2020, 27( 9): 581- 597. DOI: 10.1002/jhbp.785.
    [9]
    Lluís N, Onoe S, Serradilla-Martín M, et al. Intraductal papillary neoplasms of the bile ducts: A comparative study of a rare disease in Europe and Nagoya, Japan[J]. HPB, 2024, 26( 4): 565- 575. DOI: 10.1016/j.hpb.2024.01.009.
    [10]
    Huang X R, Zhang Z, Zhu D S, et al. Clinicopathological and prognosis analysis of intraductal papillary neoplasm of the bile duct: A dual-center retrospective study[J]. Eur J Surg Oncol, 2025, 51( 9): 110212. DOI: 10.1016/j.ejso.2025.110212.
    [11]
    Chang Xiaoyan, Li Ji, Ren Xinyu, et al. Intraductal papillary neoplasms of intrahepatic bile duct: A clinicopathologic study of 25 cases[J]. Chin J Pathol, 2016, 45( 4): 243- 247. DOI: 10.3760/cma.j.issn.0529-5807.2016.04.006.

    常晓燕, 李霁, 任新瑜, 等. 肝内胆管内乳头状肿瘤临床及病理学分析[J]. 中华病理学杂志, 2016, 45( 4): 243- 247. DOI: 10.3760/cma.j.issn.0529-5807.2016.04.006.
    [12]
    Han S Y, Kim D U, Nam H S, et al. Comparison of the malignant predictors in intrahepatic and extrahepatic intraductal papillary neoplasm of the bile duct[J]. J Clin Med, 2022, 11( 7): 1985. DOI: 10.3390/jcm11071985.
    [13]
    Kim J R, Jang K T, Jang J Y, et al. Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study[J]. HPB, 2020, 22( 8): 1139- 1148. DOI: 10.1016/j.hpb.2019.11.007.
    [14]
    Chun J, Sung Y N, An S, et al. Oncocytic type has distinct immunohistochemical and recurrence-free survival than other histologic types of the intraductal papillary neoplasm of the bile duct[J]. Hum Pathol, 2024, 148: 72- 80. DOI: 10.1016/j.humpath.2024.05.006.
    [15]
    Nakanuma Y, Kakuda Y, Fukumura Y, et al. The pathologic and genetic characteristics of the intestinal subtype of intraductal papillary neoplasms of the bile duct[J]. Am J Surg Pathol, 2019, 43( 9): 1212- 1220. DOI: 10.1097/PAS.0000000000001295.
    [16]
    Nakanuma Y, Kakuda Y, Sugino T, et al. Pathologies of precursor lesions of biliary tract carcinoma[J]. Cancers, 2022, 14( 21): 5358. DOI: 10.3390/cancers14215358.
    [17]
    Chung T, Oh S, Won J, et al. Genomic and transcriptomic signatures of sequential carcinogenesis from papillary neoplasm to biliary tract cancer[J]. J Hepatol, 2025, 83( 1): 119- 130. DOI: 10.1016/j.jhep.2025.01.007.
    [18]
    Huang Deng, Gan Lang. Clinical status and research progress of intraductal papillary neoplasm of the bile duct[J]. Chin J Dig Surg, 2024, 23( 7): 919- 925. DOI: 10.3760/cma.j.cn115610-20240523-00259.

    黄登, 甘浪. 胆管内乳头状肿瘤的临床现状和研究进展[J]. 中华消化外科杂志, 2024, 23( 7): 919- 925. DOI: 10.3760/cma.j.cn115610-20240523-00259.
    [19]
    Wang Haonian, Sun Bei, Chen Hua. Diagnosis and treatment strategies for intraductal papillary neoplasm of the bile duct[J/OL]. Chin J Liver Dis(Electronic Version), 2024, 13( 2): 140- 144. DOI: 10.3877/cma.j.issn.2095-3232.2024.02.004

    王浩年, 孙备, 陈华. 胆管内乳头状肿瘤的诊治策略[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13( 2): 140- 144. DOI: 10.3877/cma.j.issn.2095-3232.2024.02.004.
    [20]
    Noguchi D, Kuriyama N, Kozuka Y, et al. A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features[J]. PLoS One, 2025, 20( 5): e0325081. DOI: 10.1371/journal.pone.0325081.
    [21]
    Zhang Y Q, Liang Y, Liu Y, et al. Photodynamic therapy for hepatic hilar intraductal papillary neoplasm of the bile duct: A case report[J]. VideoGIE, 2022, 7( 5): 178- 181. DOI: 10.1016/j.vgie.2022.01.016.
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