中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 42 Issue 7
Jul.  2026
Turn off MathJax
Article Contents

Interpretation of guidelines for the diagnosis and treatment of primary liver cancer (2026 edition)

DOI: 10.12449/JCH260713
Research funding:

Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0502003)

More Information
  • Corresponding author: Li Zhao, lizhao@pku.edu.cn (ORCID: 0000-0003-0512-2835)
  • Received Date: 2026-06-04
  • Accepted Date: 2026-06-24
  • Published Date: 2026-07-25
  • In April 2026, the National Health Commission of the People’s Republic of China released Guidelines for the diagnosis and treatment of primary liver cancer (2026 edition). This edition incorporates an independent chapter of “prevention, screening, and monitoring” to build a hierarchical and precise prevention and control system, establishes a comprehensive therapeutic paradigm targeting surgical resection, and clarifies the core position of conversion therapy and neoadjuvant therapy. It also updates the recommendations for interventional and systemic therapies and strengthens the whole-course management of underlying liver diseases. This article interprets the key updates of this new edition to better guide clinical practice.

     

  • loading
  • [1]
    Han B F, Zheng R S, Zeng H M, et al. Cancer incidence and mortality in China, 2022[J]. J Natl Cancer Cent, 2024, 4( 1): 47- 53. DOI: 10.1016/j.jncc.2024.01.006.
    [2]
    National Health Commission of the People’s Republic of China. Standard for diagnosis and treatment of primary liver cancer(2024 edition)[J]. J Clin Hepatol, 2024, 40( 5): 893- 918. DOI: 10.12449/JCH240508.

    中华人民共和国国家卫生健康委员会. 原发性肝癌诊疗指南(2024年版)[J]. 临床肝胆病杂志, 2024, 40( 5): 893- 918. DOI: 10.12449/JCH240508.
    [3]
    National Health Commission of the People’s Republic of China. Guideline for diagnosis and treatment of primary liver cancer(2026 edition)[J]. J Clin Hepatol, 2026, 42( 4): 794- 827. DOI: 10.12449/JCH260409.

    中华人民共和国国家卫生健康委员会. 原发性肝癌诊疗指南(2026年版)[J]. 临床肝胆病杂志, 2026, 42( 4): 794- 827. DOI: 10.12449/JCH260409.
    [4]
    Chan S L, Sun H C, Xu Y, et al. The Lancet Commission on addressing the global hepatocellular carcinoma burden: Comprehensive strategies from prevention to treatment[J]. Lancet, 2025, 406( 10504): 731- 778. DOI: 10.1016/S0140-6736(25)01042-6.
    [5]
    Fan R, Papatheodoridis G, Sun J, et al. aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis[J]. J Hepatol, 2020, 73( 6): 1368- 1378. DOI: 10.1016/j.jhep.2020.07.025.
    [6]
    Fan R, Chen L, Zhao S R, et al. Novel, high accuracy models for hepatocellular carcinoma prediction based on longitudinal data and cell-free DNA signatures[J]. J Hepatol, 2023, 79( 4): 933- 944. DOI: 10.1016/j.jhep.2023.05.039.
    [7]
    Vitale A, Romano P, Cillo U, et al. Liver resection vs nonsurgical treatments for patients with early multinodular hepatocellular carcinoma[J]. JAMA Surg, 2024, 159( 8): 881- 889. DOI: 10.1001/jamasurg.2024.1184.
    [8]
    Liu R, Abu Hilal M, Wakabayashi G, et al. International experts consensus guidelines on robotic liver resection in 2023[J]. World J Gastroenterol, 2023, 29( 32): 4815- 4830. DOI: 10.3748/wjg.v29.i32.4815.
    [9]
    Chiang C L, Chan K S K, Chiu K W H, et al. Complete response to locoregional therapy plus immunotherapy for hepatocellular carcinoma[J]. JAMA Oncol, 2024, 10( 11): 1548- 1553. DOI: 10.1001/jamaoncol.2024.4085.
    [10]
    Wang Z, Fan J, Zhou S L, et al. Perioperative camrelizumab plus rivoceranib versus surgery alone in patients with resectable hepatocellular carcinoma at intermediate or high risk of recurrence(CARES-009): A randomised phase 2/3 trial[J]. Lancet, 2025, 406( 10515): 2089- 2099. DOI: 10.1016/S0140-6736(25)01720-9.
    [11]
    Dong J, Han G, Ogasawara S, et al. LBA2 TALENTACE: A phase III, open-label, randomized study of on-demand transarterial chemoembolization(TACE) combined with atezolizumab + bevacizumab(Atezo+Bev) or on-demand TACE alone in patients with systemically untreated, intermediate-to-high burden unresectable hepatocellular carcinoma(uHCC)[J]. Ann Oncol, 2025, 36: S62. DOI: 10.1016/j.annonc.2025.05.542.
    [12]
    Kudo M, Ren Z G, Guo Y B, et al. Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma(LEAP-012): A multicentre, randomised, double-blind, phase 3 study[J]. Lancet, 2025, 405( 10474): 203- 215. DOI: 10.1016/S0140-6736(24)02575-3.
    [13]
    Sangro B, Kudo M, Erinjeri J P, et al. Durvalumab with or without bevacizumab with transarterial chemoembolisation in hepatocellular carcinoma(EMERALD-1): A multiregional, randomised, double-blind, placebo-controlled, phase 3 study[J]. Lancet, 2025, 405( 10474): 216- 232. DOI: 10.1016/S0140-6736(24)02551-0.
    [14]
    Yau T, Galle P R, Decaens T, et al. Nivolumab plus ipilimumab versus lenvatinib or sorafenib as first-line treatment for unresectable hepatocellular carcinoma(CheckMate 9DW): An open-label, randomised, phase 3 trial[J]. Lancet, 2025, 405( 10492): 1851- 1864. DOI: 10.1016/S0140-6736(25)00403-9.
    [15]
    Xu J M, Zhang Y Q, Wang G, et al. SCT-I10A combined with a bevacizumab biosimilar(SCT510) versus sorafenib in the first-line treatment of advanced hepatocellular carcinoma: A randomized phase 3 trial[J]. J Clin Oncol, 2024, 42( 16_suppl): 4092. DOI: 10.1200/jco.2024.42.16_suppl.4092.
    [16]
    Shi Y H, Han G H, Zhou J, et al. Toripalimab plus bevacizumab versus sorafenib as first-line treatment for advanced hepatocellular carcinoma(HEPATORCH): A randomised, open-label, phase 3 trial[J]. Lancet Gastroenterol Hepatol, 2025, 10( 7): 658- 670. DOI: 10.1016/S2468-1253(25)00059-7.
    [17]
    Zhou J, Bai L, Luo J, et al. Anlotinib plus penpulimab versus sorafenib in the first-line treatment of unresectable hepatocellular carcinoma(APOLLO): A randomised, controlled, phase 3 trial[J]. Lancet Oncol, 2025, 26( 6): 719- 731. DOI: 10.1016/S1470-2045(25)00190-1.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (155) PDF downloads(76) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return