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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 42 Issue 7
Jul.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(7): 1493-1500

Advances in basic research on ultrasound diagnosis and treatment of hepatocellular carcinoma: From diagnosis and treatment to integrated management

DOI: 10.12449/JCH260702
  • 1.

    Department of Ultrasound，Zhongshan Hospital，Fudan University，Shanghai 200032，China

  • 2.

    Institute of Ultrasound in Medicine and Engineering，Fudan University，Shanghai 200032，China

  • 3.

    Shanghai Institute of Medical Imaging，Shanghai 200032，China

Research funding:

National Natural Science Foundation of China (82302206);

National Natural Science Foundation of China (82430064);

National Key R&D Program of China (2023YFC2414204);

National Key R&D Program of China (2023YFC2414203);

National Key R&D Program of China (2023YFC2414202);

Scientific Development Fund of Zhongshan Hospital, Fudan University (2022ZSQD07);

Shanghai Sailing Program (23YF1441600);

China Postdoctoral Science Foundation (2023TQ0073)

More Information
  • Corresponding author: Xu Huixiong， xuhuixiong@126.com （ORCID： 0000-0002-9878-8590）
  • Received Date: 2026-05-26
  • Accepted Date: 2026-07-17
  • Published Date: 2026-07-25
    Abstract
  • The precise diagnosis and treatment of hepatocellular carcinoma （HCC） face major challenges such as the complexity of tumor microenvironment， treatment resistance， and a high risk of recurrence and metastasis. In recent years， ultrasound technology has moved beyond its traditional role in screening and localization， gradually evolving into a multidimensional therapeutic platform capable of energy activation， targeted delivery， local ablation， immune modulation， and therapeutic feedback. This article systematically reviews the latest advances in the basic research on ultrasound techniques in HCC treatment and integrated management. In terms of treatment， intervention strategies represented by microbubble/nanobubble-mediated delivery， sonodynamic therapy， high-intensity focused ultrasound， and histotripsy not only enable in situ physical destruction of lesions， but also effectively reverse tumor immune tolerance networks through deep synergy with sonogenetics， metabolic reprogramming， and immunochemotherapy. In terms of integrated management， novel sonosensitive nanodelivery systems provide a platform for energy activation and targeted controlled release. To address the translational bottlenecks in this field， it is recommended to develop standardized consensus on preclinical therapeutic ultrasound parameters， in order to establish a new translational paradigm for individualized precise diagnosis and treatment of HCC.

     

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