| [1] |
SORRENTINO G. Microenvironmental control of the ductular reaction: Balancing repair and disease progression[J]. Cell Death Dis, 2025, 16( 1): 246. DOI: 10.1038/s41419-025-07590-4. |
| [2] |
HU YH, BAO XY, ZHANG Z, et al. Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling[J]. Theranostics, 2024, 14( 6): 2379- 2395. DOI: 10.7150/thno.91572. |
| [3] |
GUPTA V, SEHRAWAT TS, PINZANI M, et al. Portal fibrosis and the ductular reaction: Pathophysiological role in the progression of liver disease and translational opportunities[J]. Gastroenterology, 2025, 168( 4): 675- 690. DOI: 10.1053/j.gastro.2024.07.044. |
| [4] |
KAMIMOTO K, KANEKO K, KOK CY, et al. Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling[J]. eLife, 2016, 5: e15034. DOI: 10.7554/eLife.15034. |
| [5] |
ESPAÑOL-SUÑER R, CARPENTIER R, van HUL N, et al. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice[J]. Gastroenterology, 2012, 143( 6): 1564- 1575.e7. DOI: 10.1053/j.gastro.2012.08.024. |
| [6] |
SACKETT SD, LI ZD, HURTT R, et al. Foxl1 is a marker of bipotential hepatic progenitor cells in mice[J]. Hepatology, 2009, 49( 3): 920- 929. DOI: 10.1002/hep.22705. |
| [7] |
TARLOW BD, PELZ C, NAUGLER WE, et al. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes[J]. Cell Stem Cell, 2014, 15( 5): 605- 618. DOI: 10.1016/j.stem.2014.09.008. |
| [8] |
FONT-BURGADA J, SHALAPOUR S, RAMASWAMY S, et al. Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer[J]. Cell, 2015, 162( 4): 766- 779. DOI: 10.1016/j.cell.2015.07.026. |
| [9] |
|
| [10] |
ZHAO JY, YUE P, MI NN, et al. Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: From molecular mechanisms to clinical implications[J]. Med Rev, 2024, 4( 4): 326- 365. DOI: 10.1515/mr-2024-0029. |
| [11] |
BAEK EB, EUN HS, SONG JY, et al. Vitamin D supplementation ameliorates ductular reaction, liver inflammation and fibrosis in mice by upregulating TXNIP in ductular cells[J]. Nat Commun, 2025, 16( 1): 4420. DOI: 10.1038/s41467-025-59724-z. |
| [12] |
JIANG XJ, OTTERDAL K, CHUNG BK, et al. Cholangiocytes modulate CD100 expression in the liver and facilitate pathogenic T-helper 17 cell differentiation[J]. Gastroenterology, 2024, 166( 4): 667- 679. DOI: 10.1053/j.gastro.2023.11.283. |
| [13] |
GUICCIARDI ME, TRUSSONI CE, LARUSSO NF, et al. The spectrum of reactive cholangiocytes in primary sclerosing cholangitis[J]. Hepatology, 2020, 71( 2): 741- 748. DOI: 10.1002/hep.31067. |
| [14] |
CAI XR, TACKE F, GUILLOT A, et al. Cholangiokines: Undervalued modulators in the hepatic microenvironment[J]. Front Immunol, 2023, 14: 1192840. DOI: 10.3389/fimmu.2023.1192840. |
| [15] |
HE YH, PAN JX, XU LM, et al. Ductular reaction in non-alcoholic fatty liver disease: When Macbeth is perverted[J]. World J Hepatol, 2023, 15( 6): 725- 740. DOI: 10.4254/wjh.v15.i6.725. |
| [16] |
YILDIZ E, ALAM G EL, PERINO A, et al. Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs[J]. eLife, 2023, 12: e81926. DOI: 10.7554/eLife.81926. |
| [17] |
ZHENG LH, HAN Y. Personalized diagnosis and treatment strategies for primary biliary cholangitis[J]. J Clin Hepatol, 2025, 41( 7): 1270- 1274. DOI: 10.12449/JCH250707. |
| [18] |
LI B, ZHANG J, CHEN Y, et al. Alterations in microbiota and their metabolites are associated with beneficial effects of bile acid sequestrant on icteric primary biliary cholangitis[J]. Gut Microbes, 2021, 13( 1): 1946366. DOI: 10.1080/19490976.2021.1946366. |
| [19] |
DAI Z, SONG GQ, BALAKRISHNAN A, et al. Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells[J]. Gut, 2020, 69( 6): 1104- 1115. DOI: 10.1136/gutjnl-2019-318812. |
| [20] |
CAO WL, LI M, LIU JY, et al. LGR5 marks targetable tumor-initiating cells in mouse liver cancer[J]. Nat Commun, 2020, 11( 1): 1961. DOI: 10.1038/s41467-020-15846-0. |
| [21] |
CAROLINA E, KUSE Y, OKUMURA A, et al. Generation of human iPSC-derived 3D bile duct within liver organoid by incorporating human iPSC-derived blood vessel[J]. Nat Commun, 2024, 15( 1): 7424. DOI: 10.1038/s41467-024-51487-3. |
| [22] |
OGAWA M, JIANG JX, XIA S, et al. Generation of functional ciliated cholangiocytes from human pluripotent stem cells[J]. Nat Commun, 2021, 12( 1): 6504. DOI: 10.1038/s41467-021-26764-0. |
| [23] |
CHEN L, ELIZALDE M, DUBOIS LJ, et al. GAL3ST1 deficiency reduces epithelial-mesenchymal transition and tumorigenic capacity in a cholangiocarcinoma cell line[J]. Int J Mol Sci, 2024, 25( 13): 7279. DOI: 10.3390/ijms25137279. |
| [24] |
CHAIYADET S, TANGKAWATTANA S, SMOUT MJ, et al. Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini[J]. PLoS Pathog, 2022, 18( 9): e1010839. DOI: 10.1371/journal.ppat.1010839. |
| [25] |
PICARD FSR, LUTZ V, BRICHKINA A, et al. IL-17A-producing CD8 + T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts[J]. Gut, 2023, 72( 8): 1510- 1522. DOI: 10.1136/gutjnl-2022-327855. |
| [26] |
Society of Microecology, Chinese Preventive Medical Association. Evidence-based guideline for pediatric clinical application of probiotics(2023)[J]. Chin J Pract Pediatr, 2024, 39( 1): 1- 15, 20. DOI: 10.19538/j.ek2024010601. |
| [27] |
LIU YH, CHEN KF, LI FY, et al. Probiotic Lactobacillus rhamnosus GG prevents liver fibrosis through inhibiting hepatic bile acid synthesis and enhancing bile acid excretion in mice[J]. Hepatology, 2020, 71( 6): 2050- 2066. DOI: 10.1002/hep.30975. |
| [28] |
MOON SH. Advances in IgG4-related hepatobiliary disease[J]. Korean J Pancreas Biliary Tract, 2020, 25( 2): 100- 106. DOI: 10.15279/kpba.2020.25.2.100. |
| [29] |
LIU XL, PAN Q, CAO HX, et al. Lipotoxic hepatocyte-derived exosomal microRNA 192-5p activates macrophages through rictor/Akt/forkhead box transcription factor O1 signaling in nonalcoholic fatty liver disease[J]. Hepatology, 2020, 72( 2): 454- 469. DOI: 10.1002/hep.31050. |
| [30] |
BARRY-HAMILTON V, SPANGLER R, MARSHALL D, et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment[J]. Nat Med, 2010, 16( 9): 1009- 1017. DOI: 10.1038/nm.2208. |
| [31] |
LIU HY, YIN G, FRANCO LEONARDI B, et al. Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming[J]. Gut, 2025, 74( 10): e334425. DOI: 10.1136/gutjnl-2024-334425. |
| [32] |
WU N, ZHOU TH, CARPINO G, et al. Prolonged administration of a secretin receptor antagonist inhibits biliary senescence and liver fibrosis in Mdr2 -/- mice[J]. Hepatology, 2023, 77( 6): 1849- 1865. DOI: 10.1097/HEP.0000000000000310. |
| [33] |
CHEN ZW, KANG FP, XIE CK, et al. A novel Trojan horse nanotherapy strategy targeting the cPKM-STMN1/TGFB1 axis for effective treatment of intrahepatic cholangiocarcinoma[J]. Adv Sci, 2023, 10( 32): 2303814. DOI: 10.1002/advs.202303814. |
| [34] |
HU CL, WANG L. Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes[J]. Stem Cell Res Ther, 2024, 15( 1): 474. DOI: 10.1186/s13287-024-04087-3. |
| [35] |
KIM Y, KANG K, LEE SB, et al. Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells[J]. J Hepatol, 2019, 70( 1): 97- 107. DOI: 10.1016/j.jhep.2018.09.007. |
DownLoad: