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Volume 42 Issue 3
Mar.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(3): 704-710

Regulatory effect of histone lactylation modification in hepatic fibrosis

DOI: 10.12449/JCH260328

  • Department of Laboratory Medicine，The Second Xiangya Hospital of Central South University，Hunan Clinical Molecular Diagnosis Center，Hunan Engineering Research Center of Molecular Diagnosis Technology，Hunan Clinical Medical Research Center of Molecular Diagnosis of Infectious Diseases，Changsha 410011，China

Research funding:

National Natural Science Foundation of China (82270658);

Postgraduate Innovation Project of Central South University (2024XQLH103)

More Information
  • Corresponding author: HU Min， huminjyk@csu.edu.cn （ORCID： 0000-0001-7886-8174）
  • Received Date: 2025-07-15
  • Accepted Date: 2025-08-06
  • Published Date: 2026-03-25
    Abstract
  • Hepatic fibrosis is a reversible pathological process in various chronic liver diseases and is closely associated with the development and progression of severe liver diseases such as liver cirrhosis and hepatocellular carcinoma， and it has emerged as a significant global health challenge. In recent years， studies have shown that histone lactylation， a newly discovered epigenetic modification， actively participates in regulating the progression of hepatic fibrosis. This article systematically reviews the core regulatory effect of histone lactylation modification in the interaction between inflammatory microenvironment and hepatic fibrosis， in order to clarify the cascade regulatory mechanism of “inflammation-hepatic fibrosis” and provide new insights for early diagnosis， targeted intervention， and prevention of malignant transformation in hepatic fibrosis.

     

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