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Volume 42 Issue 3
Mar.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(3): 697-703

Regulatory effect of ten-eleven translocation 2-mediated epigenetics and the interaction between gut microbiota and immunity on autoimmune hepatitis

DOI: 10.12449/JCH260327
  • 1.

    Department of Spleen，Stomach，Liver and Gallbladder，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

  • 2.

    Department of Hepatology，Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200032，China

Research funding:

Henan Provincial Natural Science Foundation (222300420490);

Henan Provincial Joint Fund for Science and Technology Research (222301420069);

2023 Annual Special Research Project for the Creation of “Double First-Class” in Henan Province’s Traditional Chinese Medicine (HSRP-DFCTCM-2023-7-24);

2023 Research Project of Henan Provincial Health Commission for the National Center of Inheritance and Innovation of Traditional Chinese Medicine (2023ZXZX1129)

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  • Corresponding author: LIU Guangwei， liuguangwei1975@163.com （ORCID： 0000-0002-6641-1625）
  • Received Date: 2025-06-29
  • Accepted Date: 2025-07-30
  • Published Date: 2026-03-25
    Abstract
  • Ten-eleven translocation 2 （TET2）， as a core enzyme in epigenetic regulation， dynamically regulates the differentiation and function of CD4+ T cells by mediating DNA demethylation. Recent studies have shown that TET2 deficiency can promote the progression of autoimmune hepatitis （AIH） by disrupting the Th17/Treg balance and activating inflammatory signals along the gut-liver axis. This article systematically reviews the bridging role of TET2 between CD4+ T cells and gut microbiota， explores the molecular mechanisms by which it drives AIH through the gut microbiota-epigenetics-immunity network， and discusses the potential intervention strategies targeting the TET2-microbiota axis.

     

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