Rotor syndrome in pregnancy： A case report

Lijie GAO; Yanbo MO; Xiaonan LIANG; Xiaolan ZHANG

doi:10.12449/JCH260321

Volume 42 Issue 3

Mar. 2026

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Article Navigation > Journal of Clinical Hepatology > 2026 > 42(3): 655-660

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Rotor syndrome in pregnancy： A case report

DOI: 10.12449/JCH260321

1.
Department of Gastroenterology，The Second Hospital of Hebei Medical University，Shijiazhuang 050035，China
2.
Department of Gastroenterology，The Affiliated Hospital of North China University of Science and Technology，Tangshan，Hebei 063000，China

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Corresponding author: ZHANG Xiaolan， xiaolanzh@126.com （ORCID： 0009-0001-5091-2812）
Received Date: 2025-07-02
Accepted Date: 2025-08-25
Published Date: 2026-03-25

Abstract

Abstract

Rotor syndrome is an autosomal recessive disorder of bilirubin metabolism， and it is difficult to diagnose and differentiate due to its extreme rarity and a lack of specific clinical manifestations. In recent years， the development of genetic testing technology has enabled the early diagnosis of atypical patients. Literature search shows that only 19 cases with detailed clinical and genetic data have been reported. This article reports a case of a pregnant woman with an increase in direct bilirubin during pregnancy who was diagnosed with Rotor syndrome based on a bi-allelic mutation in the SLCO1B1 and SLCO1B3 genes and delivered successfully at last， and a retrospective analysis was performed for related articles， in order to facilitate the early accurate diagnosis of patients with Rotor syndrome and guide medications from the perspective of genetic mechanisms.
- Rotor Syndrome,
- Pregnancy,
- Diagnosis

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References

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Rotor syndrome in pregnancy： A case report

DOI: 10.12449/JCH260321

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Rotor syndrome in pregnancy： A case report

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