Clinical phenotypes and pathogenic mechanisms of Wilson disease with lipid metabolism disorders

Dongjing GAO; Ruixin WANG; Xinhua LI

doi:10.12449/JCH260304

Volume 42 Issue 3

Mar. 2026

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Article Navigation > Journal of Clinical Hepatology > 2026 > 42(3): 515-521

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Clinical phenotypes and pathogenic mechanisms of Wilson disease with lipid metabolism disorders

DOI: 10.12449/JCH260304

Department of Infectious Diseases，The Third Affiliated Hospital of Sun Yat-Sen University；Guangdong Provincial Key Laboratory of Liver Disease Research；Clinical Laboratory of Pathogenic Microbiology，Guangzhou 510630，China

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Corresponding author: LI Xinhua， lixinh8@mail.sysu.edu.cn （ORCID： 0000-0002-6748-9803）
Received Date: 2025-12-26
Accepted Date: 2026-02-09
Published Date: 2026-03-25

Abstract

Abstract

Wilson disease （WD） is a hereditary disorder of copper metabolism characterized by abnormal copper accumulation in tissues， including the liver and brain， which leads to severe hepatic and neurological damage. This disease is often accompanied by lipid metabolism abnormalities， and the exploration of related mechanisms has attracted increasing attention. This article introduces the clinical features of lipid metabolism disorders in WD patients， summarizes the research advances in the serum levels of lipids and hepatic steatosis， analyzes the potential mechanisms of the interaction between copper and lipid metabolism， and highlights the significance of lipid-related molecules in disease diagnosis and clinical evaluation. In clinical practice， the monitoring and assessment of lipid metabolism parameters should be taken seriously in patients with WD， in order to promote comprehensive disease management and improve the prognosis of patients.
- Hepatolenticular Degeneration,
- Lipid Metabolism Disorders,
- Pathologic Processes

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References(52)

References

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Clinical phenotypes and pathogenic mechanisms of Wilson disease with lipid metabolism disorders

DOI: 10.12449/JCH260304

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Clinical phenotypes and pathogenic mechanisms of Wilson disease with lipid metabolism disorders

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