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CN 22-1108/R
Volume 41 Issue 9
Sep.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(9): 1956-1960

Mechanism of action of energy metabolism in hepatic ischemia-reperfusion injury and related targeted therapies

DOI: 10.12449/JCH250937
  • 1.

    School of Medicine，Wuhan University of Science and Technology，Wuhan 430065，China

  • 2.

    Department of Gastroenterology，General Hospital of Central Theater Command，Wuhan 430012，China

Research funding:

National Natural Science Foundation of China (82200708);

Natural Science Foundation of Hubei Province (2021CFB001)

More Information
  • Corresponding author: ZHANG Song， hbzhangs@163.com （ORCID： 0000-0002-3855-2113）
  • Received Date: 2025-02-17
  • Accepted Date: 2025-04-11
  • Published Date: 2025-09-25
    Abstract
  • Hepatic ischemia-reperfusion injury （HIRI） is an inevitable major complication during surgical procedures such as liver transplantation and partial hepatectomy， and its prevention and treatment are hotspots and difficulties in clinical practice. This article reviews the mechanism of injury caused by energy metabolism disorders during liver ischemia-reperfusion and related treatment strategies and summarizes the current advances in metabolism-related therapies， in order to provide new ideas for further clarifying the onset mechanism of HIRI and exploring effective clinical prevention and treatment strategies for HIRI.

     

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