Gene therapy for hepatocellular carcinoma： Current research status and challenges

Huimin DOU; Wanxiang WANG

doi:10.12449/JCH250931

Volume 41 Issue 9

Sep. 2025

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Gene therapy for hepatocellular carcinoma： Current research status and challenges

DOI: 10.12449/JCH250931

Huimin DOU¹,
Wanxiang WANG^{2
,
,
,}

1.
The First Clinical Institute of Inner Mongolia Medical University，Hohhot 010059，China
2.
Department of Hepatobiliary，Pancreatic，and Spleen Surgery，The Affiliated Hospital of Inner Mongolia Medical University，Hohhot 010059，China

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Corresponding author: WANG Wanxiang， wwx6188@163.com （ORCID： 0009-0004-4147-0014）
Received Date: 2025-02-10
Accepted Date: 2025-02-21
Published Date: 2025-09-25

Abstract

Abstract

Hepatocellular carcinoma （HCC） is one of the most common malignant tumors worldwide， and most patients are in the advanced stage at the time of diagnosis， leading to a poor prognosis and a low survival rate. Traditional treatment methods often have limited efficacy， while gene therapy， as an emerging therapeutic strategy， has shown great potential with numerous challenges. This article mainly introduces the latest advances in the field of gene therapy for HCC and analyzes the key issues that need to be addressed in the future development of this field. Gene therapy has become a research hotspot in HCC due to its advantages of strong targeting， diverse mechanisms of action， and individualized treatment. Although gene therapy is still in the exploratory stage in the treatment of HCC， some preliminary research findings have been achieved. According to the reports in the literature， the combination of gene therapy with other treatment methods， such as chemotherapy and immunotherapy， can improve treatment outcomes and reduce the side effects of monotherapy. With the continuous advances in technology， gene therapy is expected to bring new hope to HCC patients.
- Carcinoma， Hepatocellular,
- Genetic Therapy,
- Therapeutics

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References

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Gene therapy for hepatocellular carcinoma： Current research status and challenges

DOI: 10.12449/JCH250931

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Gene therapy for hepatocellular carcinoma： Current research status and challenges

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