The role of dendritic cells in autoimmune liver diseases and autoimmune pancreatitis

Wenfeng XI; Xiaoyin BAI; Aiming YANG

doi:10.12449/JCH250928

Volume 41 Issue 9

Sep. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(9): 1902-1907

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The role of dendritic cells in autoimmune liver diseases and autoimmune pancreatitis

DOI: 10.12449/JCH250928

Department of Gastroenterology，Peking Union Medical College Hospital，Beijing 100730，China

Research funding:

National Natural Science Foundation of China (82470700);

Chinese Academy of Medical Science Innovation Fund for Medical Sciences (2023-I2M-2-002);

Special Project of Clinical and Translational Medicine Research, Chinese Academy of Medical Sciences (2024-I2M-CT-B-016)

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Corresponding author: BAI Xiaoyin， baixiaoyin@pumch.cn （ORCID： 0000-0002-9092-7592）; YANG Aiming， yangam2020@126.com （ORCID： 0000-0002-2907-7904）
Received Date: 2025-02-13
Accepted Date: 2025-03-12
Published Date: 2025-09-25

Abstract

Abstract

Dendritic cells （DCs）， as key regulatory cells in the immune system， play a significant role in the pathogenesis of autoimmune diseases. This article reviews the mechanism of action of DCs and related research advances in autoimmune liver diseases （including autoimmune hepatitis， primary biliary cholangitis， and primary sclerosing cholangitis） and autoimmune pancreatitis. By summarizing the functions and heterogeneity of DCs in these diseases， this article reveals the crucial role of DCs in the imbalance of immune tolerance and chronic inflammation. Related research findings provide an important basis for a deep understanding of the role of DCs in autoimmune liver diseases and autoimmune pancreatitis and lay a foundation for the development of precise treatment strategies.
- Autoimmune Diseases,
- Dendritic Cells,
- Immune Tolerance

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References(44)

References

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The role of dendritic cells in autoimmune liver diseases and autoimmune pancreatitis

DOI: 10.12449/JCH250928

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