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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 41 Issue 9
Sep.  2025
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Article Contents

Noninvasive diagnosis of anti-mitochondrial antibody-negative primary biliary cholangitis

DOI: 10.12449/JCH250927
Research funding:

National Natural Science Foundation of China (U24A20654);

National Natural Science Foundation of China (82170602);

Natural Science Foundation for Self-Exploration Research of Jilin Province (YDZJ202401427ZYTS);

Jilin Provincial Key Laboratory of Metabolic Liver Diseases (YDZJ202502CXJD002);

National Key Research and Development Program of China (2024YFE0213800)

More Information
  • Corresponding author: GAO Yanhang, yanhang@mail.jlu.edu.cn (ORCID: 0000-0001-8590-6706)
  • Received Date: 2025-01-20
  • Accepted Date: 2025-03-26
  • Published Date: 2025-09-25
  • Primary biliary cholangitis (PBC) is an autoimmune disease characterized by cholestasis of the intrahepatic bile ducts. Anti-mitochondrial antibody (AMA) is currently the key serum marker for the diagnosis of PBC, and however, there are still 5%—10% of patients with PBC who have undetectable AMA in their serum and need liver biopsy to make a confirmed diagnosis. Noninvasive diagnosis remains a challenge in AMA-negative PBC patients. This article reviews the research advances in specific serum markers other than AMA, summarizes the advantages and disadvantages of these serum markers in the diagnosis of AMA-negative PBC, and analyzes the types of new biomarkers that may be used in the noninvasive diagnosis of patients with AMA-negative PBC, in order to provide new ideas for identifying serum markers with higher sensitivities.

     

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