中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Menu

2022 No.3
Theme Issue: Autoimmune Liver Diseases — Exploring the Pathogenesis and Promoting Clinical Practice
Executive Chief Editor: YAN Huiping  
Beijing YouAn Hospital Affiliated to Capital Medical University
Cover Content

 Previous Issue | Next Issue 

Display Method:
Editorial
Review and prospect of the development in the field of autoimmune liver diseases in China over the last 20 years
Huipng YAN, Yanmin LIU, Haiping ZHANG
2022, 38(4): 737-742. DOI: 10.3969/j.issn.1001-5256.2022.04.001
Abstract(1097) HTML (261) PDF (2771KB)(204)
Abstract:
Through big data, this paper reviews the national research projects and the academic papers published in China and globally in the field of autoimmune liver diseases in China from 2001 to 2020, revealing the development trend in the past two decades. This paper also introduces the updates of the new...
Discussions by Experts
Advances in the pathogenesis of autoimmune hepatitis and new targets for clinical intervention
Mingli HU, Qixia WANG, Xiong MA
2022, 38(4): 743-747. DOI: 10.3969/j.issn.1001-5256.2022.04.002
Abstract(1387) HTML (266) PDF (1912KB)(310)
Abstract:
Autoimmune hepatitis (AIH) is an immune-mediated liver disease with hepatocytes as the main target cells. It is characterized by the high immunoglobulin G level and the presence of autoantibodies, and histological observation shows interface hepatitis at the portal area caused by a large amount of l...
The early diagnosis and treatment of atypical autoimmune liver disease should be taken seriously
Chunyang HUANG, Yanmin LIU
2022, 38(4): 748-753. DOI: 10.3969/j.issn.1001-5256.2022.04.003
Abstract(925) HTML (240) PDF (1924KB)(152)
Abstract:
Autoimmune liver disease is a group of diseases mainly caused by autoimmune abnormalities, including autoimmune hepatitis dominated by hepatocellular injury, primary biliary cholangitis and primary sclerosing cholangitis dominated by bile duct injury, and overlap syndrome with the main features of t...
The role of pathogen infections in the development and progression of autoimmune liver diseases
Haiping ZHANG, Huiping YAN, Dexi CHEN, Yingmin MA
2022, 38(4): 754-758. DOI: 10.3969/j.issn.1001-5256.2022.04.004
Abstract(690) HTML (195) PDF (1912KB)(101)
Abstract:
The etiology and pathogenesis of autoimmune liver diseases has always been a hot area of research. Pathogen infections can elicit an autoimmune response and often become the key pathogenic factor of immune diseases. Based on the literature data and the author's clinical experience, this review will ...
Genetic studies of primary biliary cholangitis in the post-GWAS era
Fang QIU, Chan WANG, Mingming ZHANG, Xingjuan SHI, Xiangdong LIU
2022, 38(4): 759-761. DOI: 10.3969/j.issn.1001-5256.2022.04.005
Abstract(894) HTML (339) PDF (1889KB)(98)
Abstract:
With the constant increase in the awareness of primary biliary cholangitis (PBC) and the continuous improvement in related diagnostic methods in the past two decades, the incidence and prevalence rates of PBC tend to increase and PBC is now the most common autoimmune liver disease worldwide. A serie...
Advances in diagnosis and treatment of IgG4-related hepatobiliary and pancreatic diseases
Tianqi WANG, Yanying LIU
2022, 38(4): 762-766. DOI: 10.3969/j.issn.1001-5256.2022.04.006
Abstract(1094) HTML (203) PDF (1911KB)(183)
Abstract:
IgG4-related hepatobiliary and pancreatic diseases are a part of the IgG4-related disease multiorgan fibroinflammatory disorder, including IgG4-related autoimmune pancreatitis, IgG4-related sclerosing cholangitis, and IgG4-related hepatic involvement. The main pathological features include IgG4+ pla...
Guidelines
Expert consensus on clinical application of artificial liver and blood purification (2022 edition)
Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association
2022, 38(4): 767-775. DOI: 10.3969/j.issn.1001-5256.2022.04.007
Abstract(2144) HTML (326) PDF (2320KB)(705)
Abstract:
Clinical management guidelines for acute fatty liver of pregnancy in China (2022)
Obstetrics Subgroup, Chinese Society of Obstetrics and Gynecology, Chinese Medical Association
2022, 38(4): 776-783. DOI: 10.3760/cma.j.cn112141-20210907-00499
Abstract(1535) HTML (1214) PDF (2822KB)(514)
Abstract:
Acute fatty liver of pregnancy (AFLP) is a rare but critical obstetric disease with a high mortality rate, and it poses a serious threat to the safety of the mother and the child. The guidelines are developed to standardize clinical management and improve the outcome of the mother and the child. Bas...
An excerpt of AASLD practice guidance: Palliative care and symptom-based management in decompensated cirrhosis (2022)
Fu GUAN, Shengbing WANG, Mingqing ZHANG
2022, 38(4): 784-787. DOI: 10.3969/j.issn.1001-5256.2022.04.009
Abstract(917) HTML (725) PDF (1869KB)(188)
Abstract:
Original Articles_Viral Hepatitis
Clinical features and prognosis of HBV-related acute-on-chronic liver failure in pregnancy
Liujuan JI, Xue MEI, Wei YUAN, Ying ZOU, Yu LIU, Jiefei WANG, Zhiping QIAN
2022, 38(4): 788-792. DOI: 10.3969/j.issn.1001-5256.2022.04.010
Abstract(695) HTML (166) PDF (1906KB)(49)
Abstract:
Objective To investigate the clinical features and prognosis of pregnant women with HBV-related acute-on-chronic liver failure (HBV-ACLF). Methods A retrospective analysis was performed for the clinical data of 26 pregnant women with HBV-ACLF who were admitted to Shanghai Public Health Clinical Cent...
Epidemiological features and antiviral response of genotype 6 chronic hepatitis C
Jinni HUANG, Jianning JIANG, Dandan LIANG, Shiyu LONG, Guozhen DONG, Man SU, Jijiao LI, Chunling TENG, Ping ZHANG, Minghua SU
2022, 38(4): 793-797. DOI: 10.3969/j.issn.1001-5256.2022.04.011
Abstract(545) HTML (117) PDF (2318KB)(44)
Abstract:
Objective To investigate the epidemiological features and antiviral response of patients with genotype 6 chronic hepatitis C (CHC) in Guangxi, China. Methods A total of 97 patients with genotype 6 CHC who were admitted to The First Affiliated Hospital of Guangxi Medical University from December 2012...
Original Articles_Fatty Liver Diseases
Clinical trial protocols of new drugs for nonalcoholic steatohepatitis: A systematic review
Yingshuo HUANG, Wei WEI, Xiaofei TONG, Yameng SUN, Jianxiong ZHANG, Ruihua DONG, Jidong JIA, Hong YOU
2022, 38(4): 798-804. DOI: 10.3969/j.issn.1001-5256.2022.04.012
Abstract(1102) HTML (297) PDF (3557KB)(166)
Abstract:
Objective To describe the characteristics and registration status of clinical trials of new drugs for nonalcoholic steatohepatitis (NASH), and to provide a reference for the design and implementation of clinical trials of new drugs for NASH. Methods The U.S. Clinical Trials Database, China Clinical ...
Value of red blood cell distribution width-to-platelet ratio in evaluating metabolic-associated fatty liver disease and liver cirrhosis
Yitong BAI, Lianjie LIN, Dongmei PEI
2022, 38(4): 805-809. DOI: 10.3969/j.issn.1001-5256.2022.04.013
Abstract(877) HTML (347) PDF (2520KB)(93)
Abstract:
Objective To investigate the clinical significance of red blood cell distribution width-to-platelet ratio (RPR index) in evaluating the severity of metabolic-associated fatty liver disease and predicting fatty liver-associated cirrhosis. Methods A total of 192 patients with metabolic-associated fatt...
Original Articles_Autoimmune Liver Diseases
A preliminary study of the role of neutrophil extracellular traps in patients with primary biliary cholangitis
Yiyan OU, Nana CUI, Yao LI, Qiwei QIAN, Xiong MA, Zhengrui YOU, Min LIAN, Qixia WANG
2022, 38(4): 810-814. DOI: 10.3969/j.issn.1001-5256.2022.04.014
Abstract(1018) HTML (339) PDF (3548KB)(80)
Abstract:
Objective To investigate the expression level of neutrophil extracellular traps (NET) in the peripheral blood and liver tissue of primary biliary cholangitis (PBC) patients and its correlation with clinical biochemical parameters. Methods A total of 24 PBC patients who were admitted to Renji Hospita...
Value of baseline IgM level in predicting the treatment response of primary biliary cholangitis
Lin HAN, Qingsheng LIANG, Huan XIE, Ying CHEN, Jun ZHAO, Mingyue ZHANG, Baosen LI, Yanli DONG, Ying SUN
2022, 38(4): 815-820. DOI: 10.3969/j.issn.1001-5256.2022.04.015
Abstract(808) HTML (207) PDF (2631KB)(86)
Abstract:
Objective To investigate the association between baseline IgM level and treatment response to ursodeoxycholic acid (UDCA) in patients with primary biliary cholangitis (PBC). Methods A retrospective analysis was performed for the clinical data of 637 PBC patients who were diagnosed and treated with U...
Original Articles_Liver Fibrosis and Liver Cirrhosis
Effect of Jiedu Huayu Tongfu prescription on intestinal flora in patients with hepatitis B cirrhosis with liver-gallbladder damp-heat syndrome
Jiangkai LIU, Yameng NIU, Suling LI, Qingliang MA, Jiangwen ZHANG, Yaru ZHANG, Bingqian LI
2022, 38(4): 821-827. DOI: 10.3969/j.issn.1001-5256.2022.04.016
Abstract(657) HTML (134) PDF (3527KB)(51)
Abstract:
Objective To investigate the regulatory effect of Jiedu Huayu Tongfu prescription on intestinal homeostasis in patients with hepatitis B cirrhosis with liver-gallbladder damp-heat syndrome, as well as its effect on endotoxin, inflammatory factors, and cellular immune function. Methods A total of 72 ...
Value of Stroop test in the diagnosis of minimal hepatic encephalopathy
Teng WANG, Yijing ZHU, Shousong ZHAO
2022, 38(4): 828-831. DOI: 10.3969/j.issn.1001-5256.2022.04.017
Abstract(752) HTML (255) PDF (2164KB)(59)
Abstract:
Objective To investigate the value of Stroop test, a neuropsychological test, in the diagnosis of minimal hepatic encephalopathy (MHE). Methods A total of 96 patients with liver cirrhosis who were hospitalized in Department of Infectious Diseases, The First Affiliated Hospital of Bengbu Medical Coll...
Establishment of a mouse model of vascular endothelial-mesenchymal transdifferentiation genetic tracing and its role in liver fibrosis studies
Hao XU, Bai RUAN, Zhiwen LI, Zhiqiang FANG, Lin WANG, Kefeng DOU
2022, 38(4): 832-836. DOI: 10.3969/j.issn.1001-5256.2022.04.018
Abstract(1048) HTML (448) PDF (4480KB)(58)
Abstract:
Objective To establish Cdh5-CreERT/Acta2-tdTomato-STOPfloxed-eGFP knockin genetic tracing mice, and to investigate its application in studies on vascular endothelial cell transition in liver fibrosis. Methods Cdh5-CreERT mice were mated with Acta2-KI mice, and the Cdh5-CreERT/Acta2-KI genetic tracin...
Original Articles_Liver Neoplasms
Development of a new model for predicting recurrence after liver transplantation for hepatocellular carcinoma beyond Milan criteria
Weiqi ZHANG, Yan XIE, Chiyi CHEN, Jian HE, Yuying TAN, Yabei HUANG, Li ZHANG, Wentao JIANG
2022, 38(4): 837-842. DOI: 10.3969/j.issn.1001-5256.2022.04.019
Abstract(577) HTML (198) PDF (2530KB)(53)
Abstract:
Objective To develop a new model for predicting recurrence after liver transplantation for hepatocellular carcinoma (HCC) beyond Milan criteria based on related preoperative and postoperative indicators. Methods A retrospective analysis was performed for the clinical data of the patients with HCC be...
Value of inflammatory biomarkers in predicting the prognosis of early small hepatocellular carcinoma after radiofrequency ablation
Weike CHU, Xue WU, Peng ZHANG, Jing FENG, Bin NIU, Hui ZHOU, Yuqiang MI, Ping LI
2022, 38(4): 843-850. DOI: 10.3969/j.issn.1001-5256.2022.04.020
Abstract(581) HTML (178) PDF (4242KB)(49)
Abstract:
Objective To investigate the value of neutrophil-to-lymphocyte ratio (NLR), red blood cell distribution width-to-lymphocyte ratio (RLR), and lymphocyte-to-monocyte ratio (LMR) in predicting the prognosis of early small hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods A ret...
Guiding role of cone beam CT with DynaCT in transcatheter arterial chemoembolization for patients with primary liver cancer and its value in assessing treatment outcome
Huailong YANG, Tangli ZHONG
2022, 38(4): 851-856. DOI: 10.3969/j.issn.1001-5256.2022.04.021
Abstract(522) HTML (155) PDF (2417KB)(49)
Abstract:
Objective To investigate the effect of cone beam CT with DynaCT on liver cancer patients undergoing transcatheter arterial chemoembolization (TACE) and its influence on the prognosis of patients. Methods A total of 73 patients with primary liver cancer who attended The Second Affiliated Hospital of ...
Inhibitory effect of 6-paradol on the proliferation, migration, and invasion of intrahepatic cholangiocarcinoma cells and its mechanism
Zehao CHEN, Wenjie ZHU, Bingbing SHEN, Jianxin JIANG
2022, 38(4): 857-864. DOI: 10.3969/j.issn.1001-5256.2022.04.022
Abstract(1278) HTML (384) PDF (9970KB)(100)
Abstract:
Objective To investigate the effect of 6-paradol on the proliferation, migration, and invasion of human intrahepatic cholangiocarcinoma cells and its mechanism. Methods Human intrahepatic cholangiocarcinoma cell lines HCCC 9810 and HUCCT1 were treated with different concentrations of 6-paradol or an...
Effect of Yipi Yanggan prescription on malignant transformation of liver stem cells in rats with liver precancerous lesion and its mechanism of action
Di JU, Mi LI, Man HAN, Bingying FANG, Shuguang YAN, Jingtao LI
2022, 38(4): 865-871. DOI: 10.3969/j.issn.1001-5256.2022.04.023
Abstract(1072) HTML (349) PDF (3795KB)(48)
Abstract:
Objective To investigate the effect of Yipi Yanggan prescription on the malignant transformation of liver stem cells in liver precancerous lesion induced by diethylnitrosamine (DEN) and its possible molecular mechanism. Methods A total of 35 male Sprague-Dawley rats were randomly divided into normal...
Analysis and Evaluation on Journal
A bibliometric analysis of liver disease research articles published by Chinese mainland authors in Gastroenterology & Hepatology journals indexed in Science Citation Index Expanded
Tianye ZHAO, Yanhua WU, Yuchen PAN, Jiaxin YI, Haiyong LYU, Junqi NIU, Jing JIANG
2022, 38(4): 872-877. DOI: 10.3969/j.issn.1001-5256.2022.04.024
Abstract(753) HTML (204) PDF (2017KB)(72)
Abstract:
Objective To investigate the articles on liver diseases published by authors from China (excluding Hong Kong, Macao, and Taiwan regions) in Gastroenterology & Hepatology journals indexed in Science Citation Index Expanded (SCIE) in 2016-2020, to analyze the bibliographic and citation data of the...
Case Reports
A case of anti-HAV-IgM-positive AIH-PBC overlap syndrome
Yansha HE, Huabao LIU, Yi SONG, Xinyu CHEN, Chunyan RAO
2022, 38(4): 878-879. DOI: 10.3969/j.issn.1001-5256.2022.04.025
Abstract(596) HTML (162) PDF (2112KB)(51)
Abstract:
Local embolization combined with targeted comprehensive immunotherapy in treatment of sarcomatoid hepatocellular carcinoma: A case report
Jin LEI, Linzhi ZHANG, Yinying LU, Bowen CHEN, Shi ZUO
2022, 38(4): 880-882. DOI: 10.3969/j.issn.1001-5256.2022.04.026
Abstract(790) HTML (270) PDF (3487KB)(54)
Abstract:
A case of eosinophilia mainly manifesting as liver injury
Hao WU, Xin ZHENG, Lei ZHU, Dong YANG
2022, 38(4): 883-885. DOI: 10.3969/j.issn.1001-5256.2022.04.027
Abstract(1308) HTML (181) PDF (2636KB)(115)
Abstract:
Long-term isolated macro-aspartate aminotransferase elevation: A case report
Dongze LI, Mengmeng QU, Shaoli YOU, Sa LYU
2022, 38(4): 886-887. DOI: 10.3969/j.issn.1001-5256.2022.04.028
Abstract(529) HTML (183) PDF (2263KB)(63)
Abstract:
Hereditary spherocytosis coexisting with Gilbert's syndrome: A case report
Yujiao ZHANG, Ying ZHENG, Xiuhong WANG, Ying CAI, Anlin MA
2022, 38(4): 888-890. DOI: 10.3969/j.issn.1001-5256.2022.04.029
Abstract(834) HTML (169) PDF (2495KB)(65)
Abstract:
A case of spontaneous hepatic rupture and hemorrhage after liver transplantation
Jian MA, Lihong HE, Lingyun WANG, Yanan ZHAI, Xun LI, Lei ZHANG
2022, 38(4): 891-893. DOI: 10.3969/j.issn.1001-5256.2022.04.030
Abstract(626) HTML (248) PDF (3041KB)(32)
Abstract:
Liver abscess caused by type II gallbladder perforation: A report of 3 cases and literature review
Shaoxiong REN, Ze LIANG, Jingzhao HAN, Hongfang TUO, Yanhui PENG
2022, 38(4): 894-897. DOI: 10.3969/j.issn.1001-5256.2022.04.031
Abstract(729) HTML (186) PDF (2784KB)(41)
Abstract:
Reviews
Application of digital therapeutics in the treatment of nonalcoholic fatty liver disease
Chao SUN, Jiangao FAN
2022, 38(4): 898-901. DOI: 10.3969/j.issn.1001-5256.2022.04.032
Abstract(1067) HTML (300) PDF (1884KB)(182)
Abstract:
Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world and seriously threatens human health. So far, change in unhealthy lifestyle is still the most important treatment method for NAFLD. However, traditional lifestyle intervention depends on hospital v...
Signaling pathways involved in the active components of Polygonum cuspidatum in treatment of nonalcoholic fatty liver disease and their interaction
Shudi LI, Xinju CHEN, Jiangkai LIU, Zhen WANG, Fei DUAN, Zhuoya YUAN, Lei LIANG, Suling LI
2022, 38(4): 902-907. DOI: 10.3969/j.issn.1001-5256.2022.04.033
Abstract(1005) HTML (418) PDF (2076KB)(52)
Abstract:
The pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains unclear, and currently no effective drugs have been approved for the treatment of NAFLD. Polygonum cuspidatum is a natural traditional Chinese medicine with a long history of application, and studies have shown that it plays an imp...
Role of new noninvasive methods in guiding the diagnosis and treatment of autoimmune hepatitis
Huaie LIU, Jiandan QIAN, Chi ZHANG, Yiqi LIU, Zhi LI, Hong ZHAO, Guiqiang WANG
2022, 38(4): 908-912. DOI: 10.3969/j.issn.1001-5256.2022.04.034
Abstract(686) HTML (154) PDF (1911KB)(60)
Abstract:
Autoimmune hepatitis (AIH) is an inflammatory disease of the liver mediated by autoimmune response, and in the diagnosis and treatment of AIH, it is of great importance to accurately assess the progression of liver inflammation, screen out the patients requiring corticosteroid therapy, and evaluate ...
Research advances in obeticholic acid and fibrates in treatment of primary biliary cholangitis with poor response or intolerance to ursodeoxycholic acid
Junfang SHUAI, Ziyan HAN
2022, 38(4): 913-917. DOI: 10.3969/j.issn.1001-5256.2022.04.035
Abstract(764) HTML (450) PDF (1927KB)(106)
Abstract:
Poor response or intolerance to ursodeoxycholic acid may occur in the treatment of primary biliary cholangitis (PBC), and after switch to obeticholic acid or fibrates alone or in combination, poor response or intolerance is also observed in some treatment regimens. Clinical studies on obeticholic ac...
Influence of patent paraumbilical vein on the development of esophageal varices and esophageal variceal bleeding in liver cirrhosis: A protective factor or a risk factor?
Zhipeng CHEN, Fang YIN
2022, 38(4): 918-922. DOI: 10.3969/j.issn.1001-5256.2022.04.036
Abstract(1538) HTML (739) PDF (2602KB)(49)
Abstract:
Previous studies believe that patent paraumbilical vein in cirrhotic portal hypertension can reduce portal venous flow, portal venous pressure, and the development of esophageal varices and esophageal variceal bleeding, but there are still controversies over this issue in clinical practice. This art...
Circulating cell-free DNA-combined liquid biopsy: The key to noninvasive diagnosis of early-stage liver cancer
Tingdan YE, Xuezhong LEI
2022, 38(4): 923-926. DOI: 10.3969/j.issn.1001-5256.2022.04.037
Abstract(889) HTML (348) PDF (1983KB)(130)
Abstract:
Circulating cell-free DNA (cfDNA) is considered a promising entry point of liquid biopsy for the diagnosis of early-stage liver cancer; however, many studies have confirmed that the diagnostic efficacy of cfDNA alone is not stable, especially that quantitative test alone cannot well reflect the situ...
Role of particulate matter 2.5 in the development and progression of liver cancer
Fei ZUO, Guodong LI, Ming LIU
2022, 38(4): 927-930. DOI: 10.3969/j.issn.1001-5256.2022.04.038
Abstract(696) HTML (403) PDF (2682KB)(46)
Abstract:
Particulate matter 2.5 (PM2.5), as one of the main components of atmospheric particulate matter, has become an important factor affecting people's health; however, there are relatively few studies on the association of PM2.5 with the development and progression of liver cancer. This article reviews ...
Research advances in coronavirus disease 2019-related liver injury
Hao CUI, Jing LIANG, Huiling XIANG
2022, 38(4): 931-935. DOI: 10.3969/j.issn.1001-5256.2022.04.039
Abstract(1043) HTML (196) PDF (1916KB)(122)
Abstract:
The coronavirus disease 2019 (COVID-19) pandemic has brought great threats and challenges to global public health and has changed the priorities of medical resource allocation. A considerable proportion of patients with liver injury is observed during the clinical diagnosis and treatment of COVID-19...
Application of human serum albumin in the management of end-stage liver disease
Lu YANG, Ye XIONG, Jianrong HUANG
2022, 38(4): 936-941. DOI: 10.3969/j.issn.1001-5256.2022.04.040
Abstract(1227) HTML (411) PDF (2080KB)(97)
Abstract:
Albumin is the most abundant protein in human plasma, and its oncotic and non-oncotic functions can regulate various functions in human body. In patients with end-stage liver disease, the deterioration of disease conditions and related complications caused by the reduction, loss, and abnormal functi...
Mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in liver diseases
Yan YANG, Feilin GE, Qian HUANG, Xinyue ZHANG, Rui ZENG, Xiaohe XIAO, Zhaofang BAI, Qin SUN
2022, 38(4): 942-946. DOI: 10.3969/j.issn.1001-5256.2022.04.041
Abstract(761) HTML (266) PDF (2950KB)(41)
Abstract:
Inflammasomes play an important role in the innate immunity of the liver; however, the excessive activation of inflammasomes can lead to liver inflammation and injury. The mechanism of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome-mediated liver injury has be...
The mechanism of intestinal flora and its metabolites in the formation of cholesterol gallstones
Handong ZHAO, Peng GAO, Li ZHAN
2022, 38(4): 947-950. DOI: 10.3969/j.issn.1001-5256.2022.04.042
Abstract(1169) HTML (240) PDF (1903KB)(89)
Abstract:
Gallstone is a common digestive system disease involving multiple factors, more than 80% of which are cholesterol gallstones, and its incidence rate is increasing year by year. Recent studies have shown that intestinal flora is involved in the development and progression of cholesterol gallstones. T...
Mechanism of action of ferroptosis in cholangiocarcinoma
Mingyu YANG, Zhen YANG, Wanhua REN
2022, 38(4): 951-955. DOI: 10.3969/j.issn.1001-5256.2022.04.043
Abstract(1330) HTML (306) PDF (2261KB)(132)
Abstract:
The incidence and mortality rates of cholangiocarcinoma (CCA) are increasing constantly, and it is of great importance to explore new therapeutic targets. Ferroptosis, a unique pattern of cell death caused by iron-dependent cellular oxidative injury, is closely associated with iron metabolism and ox...
Clinical application of pancreatic exocrine function tests
Lin ZUO, Dujiang YANG, Huimin LU
2022, 38(4): 956-960. DOI: 10.3969/j.issn.1001-5256.2022.04.044
Abstract(731) HTML (430) PDF (1919KB)(68)
Abstract:
There are currently various pancreatic exocrine function tests with different indicators for detection, and there is still a lack of unified standard. This article summarizes the pancreatic exocrine function tests which are widely used or hold promise for application in clinical practice, briefly in...
Research advances in microRNA-200c in pancreatic cancer
Yao ZHANG, Kai ZHANG, Pengdong KANG, Chao MA
2022, 38(4): 961-964. DOI: 10.3969/j.issn.1001-5256.2022.04.045
Abstract(585) HTML (127) PDF (2056KB)(47)
Abstract:
MicroRNA-200c (miR-200c) is a type of non-coding small molecule RNA, which is involved in the post-transcriptional regulation of genes and is closely associated with the development and progression of tumor. This article introduces the inhibitory effect of miR-200c on the invasion and metastasis of ...
Research advances in the mechanism of tumor microenvironment in pancreatic cancer and related targeted therapy
Yiyi ZHANG, Min XU
2022, 38(4): 965-968. DOI: 10.3969/j.issn.1001-5256.2022.04.046
Abstract(1626) HTML (772) PDF (2578KB)(223)
Abstract:
The tumor microenvironment of pancreatic carcinoma is a dense matrix environment with excessive fibrosis containing pancreatic stellate cells, cancer-associated fibroblasts, immune cells, and extracellular matrix, which not only creates an environment to promote the growth and invasion of tumors, bu...
Conference Trends at Home and Abroad
APASL STC 2022:Liver fibrosis in the era of translational medicine
2022, 38(4): 836-836. DOI: 10.3969/j.issn.1001-5256.2022.04.gnwhydd1
Abstract(413) HTML (201) PDF (855KB)(45)
Abstract:
Introduction of High-quality Articles in Foreign Journals
Developmental Cell｜Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics
2022, 38(4): 856-856. DOI: 10.3969/j.issn.1001-5256.2022.04.gwjpwzjj1
Abstract(443) HTML (230) PDF (855KB)(35)
Abstract:
Journal of Hepatology｜Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity
2022, 38(4): 890-890. DOI: 10.3969/j.issn.1001-5256.2022.04.gwjpwzjj2
Abstract(349) HTML (254) PDF (858KB)(44)
Abstract:
Hepatology International｜Establishment and validation of a prognostic model for hepatitis B virus-related acute-on-chronic liver failure patients with bacterial infection
2022, 38(4): 901-901. DOI: 10.3969/j.issn.1001-5256.2022.04.gwjpwzjj3
Abstract(269) HTML (130) PDF (856KB)(32)
Abstract:
Thanks
Current reviewers
2022, 38(4): 792-792. DOI: 10.3969/j.issn.1001-5256.2022.04.zhixie1
Abstract(260) HTML (110) PDF (856KB)(33)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

Supervisor：Ministry of Education of the People's Republic of China

Sponsor：Jilin University

Academic Support: Chinese Society of Hepatology，Chinese Medical Association

Address: 461 Xinjiang Road, Changchun

Submit：0431-88782044

Peer review：0431-88783542

Email：lcgdb@vip.163.com

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

YesterdayIP[2008]YesterdayPV[3584]TodayIP[1052]TodayPV[1975]Online[90]

Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd