2021 No. 9

2021 No.9

Theme Issue: Research advances in traditional Chinese medicine treatment of primary liver cancer

Executive Chief Editor: Li Xiuhui

Beijing YouAn Hospital, Capital Medical University

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Editorial

Improving the efficacy of traditional Chinese medicine in treatment of primary liver cancer based on etiology and pathogenesis

Xiuhui LI, Huixin YUAN

2021, 37(9): 2001-2004. DOI: 10.3969/j.issn.1001-5256.2021.09.001

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Abstract:
At present, the treatment of primary liver cancer is mainly based on modern medicine. Studies have found that traditional Chinese medicine (TCM) can promote the apoptosis of hepatoma cells and regulate the immunity of human body by affecting multiple critical pathways involved in the development and...

Discussions by experts

Principles and regimens for traditional Chinese medicine diagnosis and treatment of primary liver cancer

Wenxia ZHAO, Xinju CHEN

2021, 37(9): 2005-2008. DOI: 10.3969/j.issn.1001-5256.2021.09.002

Abstract(1157)

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Abstract:
Treatment regimens for primary liver cancer mainly include surgical resection, liver transplantation, local treatment, and systemic treatment, but there are still problems such as easy metastasis, easy recurrence, and poor prognosis. Most patients are already in the advanced stage at the time of dia...

A methodological study of traditional Chinese medicine treatment of primary liver cancer

Weiqin WANG, Zhanhua GAO, Changjian YIN

2021, 37(9): 2009-2015. DOI: 10.3969/j.issn.1001-5256.2021.09.003

Abstract(1123)

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With in-depth studies on the etiology and pathogenesis, pathological viscera and bowels, and rule of disease progression of primary liver cancer in recent years, some clinical and experimental results have been achieved for the treatment of primary liver cancer with traditional Chinese medicine, suc...

Breakthrough points and difficulties in traditional Chinese medicine treatment of primary liver cancer

Mengyuan ZHAO, Guoliang ZHANG

2021, 37(9): 2016-2024. DOI: 10.3969/j.issn.1001-5256.2021.09.004

Abstract(1112)

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Primary liver cancer is one of the most common malignant tumors in China, and most patients are in the advanced stage at the time of diagnosis, with a short survival time and poor prognosis. In recent years, traditional Chinese medicine has shown its unique advantages in the prevention and treatment...

Theoretical basis and clinical significance of treating primary liver cancer from the perspective of "regulating and protecting Zhongzhou" in the spleen and stomach

Fangshi ZHU

2021, 37(9): 2025-2029. DOI: 10.3969/j.issn.1001-5256.2021.09.005

Abstract(791)

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This article analyzes and discusses the theoretical basis and clinical significance of the treatment of primary liver cancer (PLC) from the perspective of "regulating and protecting Zhongzhou" in the spleen and stomach. The development and progression of PLC is associated with the damage of "Zhongzh...

Hotspot·Perspective·Viewpoint

Prognostic grade of acute-on-chronic liver failure: Different outcomes of the same disease

Jinling DONG, Yu CHEN

2021, 37(9): 2030-2032. DOI: 10.3969/j.issn.1001-5256.2021.09.006

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Acute-on-chronic liver failure (ACLF) is a complex clinical syndrome characterized by acute liver function decompensation on the basis of chronic liver diseases, with organ failure and a high short-term mortality rate. The course of ACLF varies across patients, and the disease is reversible. Patient...

Academic contention

Should chronic hepatitis B in the indeterminate phase be treated?

Hui ZHUANG

2021, 37(9): 2033-2036. DOI: 10.3969/j.issn.1001-5256.2021.09.007

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This article discusses the definition of the indeterminate phase of chronic hepatitis B and summarizes the proportion of patients in the indeterminate phase of chronic hepatitis B among patients with chronic HBV infection, as well as their risk of hepatocellular carcinoma and related treatment recom...

Guidelines

Expert consensus on multidisciplinary diagnosis and treatment of cirrhotic portal hypertension (based on hepatic venous pressure gradient)

Beijing Society of Portal Hypertension, Beijing Medical Association, Portal Hypertension Expert Committee, Liver Disease Committee of Chinese Research Hospital Association, Liver Disease Committee of Chinese Research Hospital Association

2021, 37(9): 2037-2044. DOI: 10.3969/j.issn.1001-5256.2021.09.008

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Expert consensus on the diagnosis and treatment of acute-on-chronic liver failure with integrated traditional Chinese and Western medicine

Chinese Association of Integrative Medicine

2021, 37(9): 2045-2053. DOI: 10.3969/j.issn.1001-5256.2021.09.009

Abstract(1060)

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Expert consensus on perioperative vascular complications for liver transplantation(2021)

Perioperative Management Group, Chinese Society of Organ Transplantation, Chinese Medical Association

2021, 37(9): 2054-2057. DOI: 10.3969/j.issn.1001-5256.2021.09.010

Abstract(584)

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Vascular complications after liver transplantation are important causes of liver dysfunction and graft loss.The incidence rate range is from 5% to 25%, and the mortality rate is high. The complex and changeable vascular conditions of the donor and recipient, anastomosis techniques, infection, and ac...

Expert opinion on nutritional treatment for patients with biliary tract tumors

Chinese Society of Nutritional Oncology, Chinese Society for Parenteral and Enteral Nutrition

2021, 37(9): 2058-2061. DOI: 10.3969/j.issn.1001-5256.2021.09.011

Abstract(697)

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Although biliary tract Chinese Society of Nutritional Oncology malignancy is not common in the world, its incidence is increasing year by year and its malignancy is high. The incidence of biliary tract malignancy in China is also increasing year by year. The prognosis of patients with cholangiocarci...

Guideline Interpretation

Interpretation of Chinese expert consensus on the diagnosis and treatment of IgG4-related diseases

Jiaxin ZHOU, Wen ZHANG

2021, 37(9): 2062-2065. DOI: 10.3969/j.issn.1001-5256.2021.09.012

Abstract(1692)

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IgG4-related disease (IgG4-RD) is an immune-mediated disease characterized by chronic inflammation and fibrosis of affected organs. With a deeper understanding of this disease among Chinese scholars and the rich experience in diagnosis and treatment in recent years, an expert group was organized by ...

Original articles_Viral hepatitis

Value of aspartate aminotransferase-to-platelet ratio index, fibrosis-4, and gamma-glutamyl transpeptidase-to-platelet ratio in diagnosis of liver inflammation grade in patients with chronic hepatitis B

Xinlan ZHOU, Xin MA, Yanbing WANG, Xiufen LI, Dan HUANG, Wei LU, Zhanqing ZHANG, Rongrong DING

2021, 37(9): 2066-2070. DOI: 10.3969/j.issn.1001-5256.2021.09.013

Abstract(874)

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Abstract:
Objective To investigate the value of aspartate aminotransferase-to-platelet ratio index (APRI), fibrosis-4 (FIB-4) score, and gamma-glutamyl transpeptidase-to-platelet ratio (GPR) in diagnosis of liver inflammation grade in patients with chronic hepatitis B (CHB). Methods A total of 545 patients wi...

Value of lymphocyte subset testing in predicting HBsAg decline in chronic hepatitis B patients receiving antiviral therapy

Zhen PENG, Huiming JIN, Huibin NING, Kuan LI, Jia SHANG

2021, 37(9): 2071-2074. DOI: 10.3969/j.issn.1001-5256.2021.09.014

Abstract(471)

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Objective To investigate whether there are differences in lymphocyte subsets between chronic hepatitis B (CHB) patients receiving different antiviral treatment regimens, and to determine related predictive factors for HBsAg decline. Methods A retrospective analysis was performed for 68 treatment-exp...

Efficacy of antiviral therapy for chronic hepatitis B with nonalcoholic fatty liver disease

Ling QING, Weiqiang HUANG, Xiaohe LI, Feng CHEN, Yingxia LIU

2021, 37(9): 2075-2080. DOI: 10.3969/j.issn.1001-5256.2021.09.015

Abstract(544)

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Objective To investigate the influence of nonalcoholic fatty liver disease (NAFLD) on the antiviral response of patients with chronic hepatitis B (CHB), and to provide a reference for clinical treatment of such patients. Methods A total of 187 patients who attended Shenzhen Third People's Hospital f...

Original articles_Liver fibrosis and liver cirrhosis

Value of prothrombin time-international normalized ratio to albumin ratio in predicting the prognosis of patients with decompensated cirrhosis

Shuhui MENG, Ying XU, Songlong ZOU, Xue ZHANG, Jiefang WU

2021, 37(9): 2081-2086. DOI: 10.3969/j.issn.1001-5256.2021.09.016

Abstract(807)

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Objective To investigate the value of prothrombin time-international normalized ratio to albumin ratio (PTAR) in evaluating the prognosis of patients with decompensated cirrhosis. Methods A retrospective analysis was performed for the clinical data of 172 patients with decompensated cirrhosis who we...

Risk factors for early rebleeding after endoscopic therapy for esophageal varices in cirrhotic patients

Yan ZHANG, Huiguo DING

2021, 37(9): 2087-2091. DOI: 10.3969/j.issn.1001-5256.2021.09.017

Abstract(893)

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Objective To investigate the risk factors for early rebleeding after endoscopic ligation or sclerotherapy for esophageal variceal bleeding in cirrhotic patients. Methods A retrospective analysis was performed for the clinical data of 153 cirrhotic patients with esophageal variceal bleeding who under...

Influencing factors of rebleeding after gastroscopy in patients with liver cirrhosis and esophagogastric variceal bleeding

Jia LIAN, Tao HAN, Huiling XIANG, Yankai YANG, Tinghong LI, Lei LIU, Baiguo XU, Lixia SUN, Fei WANG, Yanchao FU

2021, 37(9): 2092-2096. DOI: 10.3969/j.issn.1001-5256.2021.09.018

Abstract(912)

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Objective To investigate the influencing factors for rebleeding after gastroscopy in patients with liver cirrhosis and esophagogastric variceal bleeding. Methods A retrospective analysis was performed for the clinical data of the patients with liver cirrhosis and esophagogastric variceal bleeding wh...

Value of albumin-bilirubin score combined with neutrophil count and procalcitonin in ascites in predicting spontaneous bacterial peritonitis in patients with cirrhotic ascites

Ping JIANG, Rencheng DOU, Zijin CUI, Yinni TONG, Chen LI, Shanshan JIANG, Yun BAI, Jimin ZHENG, Cunkai WANG, Yuzhen WANG

2021, 37(9): 2097-2101. DOI: 10.3969/j.issn.1001-5256.2021.09.019

Abstract(996)

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Objective To investigate the risk factors for spontaneous bacterial peritonitis (SBP) in patients with cirrhotic ascites, and to establish a new model for predicting the development of SBP. Methods A total of 215 patients who were diagnosed with cirrhotic ascites in Hebei General Hospital from Septe...

Expression of NLRP3 inflammatory body in a rat model of liver fibrosis induced by common bile duct ligation

Meng'en ZHOU, Yirong CHEN, Na ZHANG, Ni YAN, Renye QUE, Yong LI

2021, 37(9): 2102-2108. DOI: 10.3969/j.issn.1001-5256.2021.09.020

Abstract(984)

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Objective To investigate the expression of NLRP3 inflammatory body in the process of liver fibrosis in a rat model of common bile duct ligation (BDL) and the association of NLRP3 inflammatory body with liver fibrosis. Methods A total of 65 Sprague-Dawley rats were randomly divided into sham-operatio...

Original articles_Liver neoplasms

Value of alpha-fetoprotein combined with gamma-glutamyl transpeptidase/aspartate aminotransferase ratio in diagnosis of HBV-associated hepatocellular carcinoma

Xin CAI, Juanjuan CHEN, Dongling TANG, Ping'an ZHANG

2021, 37(9): 2109-2112. DOI: 10.3969/j.issn.1001-5256.2021.09.021

Abstract(609)

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Objective To investigate the clinical value of alpha-fetoprotein (AFP) combined with gamma-glutamyl transpeptidase (GGT)/aspartate aminotransferase (AST) ratio in the diagnosis of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). Methods A total of 352 subjects who received treatmen...

Establishment and predictive value of an early warning system for recurrence after radical resection of BCLC stage 0/A hepatocellular carcinoma

Sheng LIU, Haoyou TANG, Yang YANG, Xin ZENG, Xiaobin HUANG, Qiuhong GU, Jianshui LI

2021, 37(9): 2113-2119. DOI: 10.3969/j.issn.1001-5256.2021.09.022

Abstract(547)

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Abstract:
Objective To establish an Early Warning System for Recurrence Scoring after Radical Resection of BCLC stage 0/A Primary Liver Cancer (PLC-EWSPRS), and to investigate its predictive value. Methods A retrospective analysis was performed for the clinical data of 232 patients with BCLC stage 0/A liver c...

Efficacy and safety of sequential lenvatinib therapy after stereotactic body radiotherapy in treatment of advanced primary liver cancer

Xiaoquan JI, Aimin ZHANG, Tao ZHANG, Wengang LI, Weiping HE, Jing SUN, Xuezhang DUAN

2021, 37(9): 2120-2124. DOI: 10.3969/j.issn.1001-5256.2021.09.023

Abstract(871)

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Objective To investigate the efficacy and safety of sequential lenvatinib therapy after stereotactic body radiotherapy (SBRT) in the treatment of advanced primary liver cancer. Methods A total of 18 patients with advanced primary liver cancer who were admitted to The Fifth Medical Center of Chinese ...

A cost-effect analysis of transarterial chemoembolization with CalliSpheres beads loaded with arsenic trioxide versus arsenic trioxide iodized oil emulsion in treatment of unresectable liver cancer

Wenhui WANG, Xuhua DUAN, Hao LI, Shuguang JU, Manzhou WANG, Jianzhuang REN, Xinwei HAN

2021, 37(9): 2125-2129. DOI: 10.3969/j.issn.1001-5256.2021.09.024

Abstract(698)

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Abstract:
Objective To investigate the cost-effect of transarterial chemoembolization (TACE) with CalliSpheres beads loaded with arsenic trioxide (ATO) (CBATO) versus ATO iodized oil emulsion (conventional TACE, cTACE) in the treatment of unresectable liver cancer. Methods A total of 100 patients with advance...

Application of liver three-dimensional visualized reconstruction technique in hepatectomy for children with complicated hepatoblastoma

Di ZHAO, Jindong YE, Huali LI, Kui JIN, Xiang LIU, Xiaoran LI, Liuxin DUAN, Jungui LIU, Wei LYU, Weihong DUAN, Quanda LIU

2021, 37(9): 2130-2135. DOI: 10.3969/j.issn.1001-5256.2021.09.025

Abstract(697)

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Objective To investigate the application of liver three-dimensional (3D) visualized reconstruction technique in hepatectomy for children with complicated hepatoblastoma. Methods A retrospective analysis was performed for the clinical data of 30 children with hepatoblastoma who underwent hepatectomy ...

Mechanism of "Szechwan Chinaberry Fruit-Rhizoma Corydalis" drug combination in treatment of liver cancer based on network pharmacology

Tian ZHANG, Sijing JIA, Dongxue SUN, Fengxi LONG, Dongxin TANG, Zhu YANG

2021, 37(9): 2136-2143. DOI: 10.3969/j.issn.1001-5256.2021.09.026

Abstract(1287)

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Objective To investigate the pharmacological components of "Szechwan Chinaberry Fruit-Rhizoma Corydalis" drug combination and its potential molecular mechanism in the treatment of liver cancer based on network pharmacology. Methods Related databases, such as TCMSP, Uniprot, and GeneCard, were used t...

Original articles_Other liver diseases

Correlation of serum alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, and alkaline phosphatase with blood pressure in patients with nonalcoholic fatty liver disease in coastal regions of Shandong Province in China

Yijing LIU, Zhenzhen ZHAO, Shousheng LIU, Yanyan XU, Yongning XIN

2021, 37(9): 2144-2147. DOI: 10.3969/j.issn.1001-5256.2021.09.027

Abstract(609)

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Objective To investigate whether there was a correlation between serum liver enzyme levels and blood pressure in the Chinese Han population with nonalcoholic fatty liver disease (NAFLD) in Shandong coastal regions in China. Methods A total of 269 NAFLD patients who lived in Shandong coastal regions ...

Clinical features of patients with acute-on-chronic liver failure and bacterial infection and influencing factors for prognosis

Xiaoyan LIU, Jinhua HU, Chen LI, Jing CHEN, Jingjing TONG, Chongdan GUAN, Yuhui PENG, Peng NING, Lilong YAN, Haibin SU

2021, 37(9): 2148-2152. DOI: 10.3969/j.issn.1001-5256.2021.09.028

Abstract(706)

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Objective To investigate the clinical features of infection in patients with acute-on-chronic liver failure (ACLF) and bacterial infection and the influencing factors for 90-day survival rate. Methods The patients with ACLF who were admitted to The Fifth Medical Center of Chinese PLA General Hospita...

Postoperative complications of ex vivo liver resection combined with autologous liver transplantation in treatment of advanced hepatic alveolar echinococcosis at high altitude and related prevention and treatment strategies

Qingshan TIAN, Shaopei FENG, Yamin GUO, Xiumin HAN, Shunyun ZHAO, Chengjie YE, Yongde AN, Shile WU, Xiangqian WANG, Haibo ZHENG, Wenjun ZHU, Jide A, Wei GAO, Hongshuai PAN

2021, 37(9): 2153-2160. DOI: 10.3969/j.issn.1001-5256.2021.09.029

Abstract(718)

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Objective To investigate the postoperative complications of ex vivo liver resection combined with autologous liver transplantation in the treatment of end-stage hepatic alveolar echinococcosis at high altitude and related prevention and treatment strategies. Methods Surgical data and follow-up data ...

Establishment of the reference intervals of four biochemical parameters for liver function among adults in Changchun, China based on the indirect method

Yiting WANG, Xuewen LI, Dongyang XING, Bing HE, Jiancheng XU

2021, 37(9): 2161-2166. DOI: 10.3969/j.issn.1001-5256.2021.09.030

Abstract(493)

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Abstract:
Objective To establish the reference intervals (RIs) of the four biochemical parameters for liver function [aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP)] in adults by using the indirect method based on the data ...

Practice and thinking on constructing a scientific research system for regional liver pathology center under the concept of collaborative innovation

Hong TANG, Yingwei ZHU, Zhonghua LU

2021, 37(9): 2167-2170. DOI: 10.3969/j.issn.1001-5256.2021.09.031

Abstract(471)

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Abstract:
Objective To investigate the influence of the concept of collaborative innovation on the construction of a scientific research system for regional liver pathology center from multiple perspectives, and to explore its application significance. Methods A total of 1246 liver biopsy specimens which were...

Original articles_Biliary disease

Effects of FGB gene polymorphism on fibrinogen level and gallstones incidence in Xinjiang, China

Aipire ALIYEGULI, Maimaitiyusufu PIERDIWASI, Jian WANG, Aili AIKEBAIER, Abudureyimu KELIMU

2021, 37(9): 2171-2176. DOI: 10.3969/j.issn.1001-5256.2021.09.032

Abstract(418)

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Abstract:
Objective To investigate the association of the polymorphisms of the FGB gene rs4220 and rs1044291 loci with plasma fibrinogen (Fg) level and gallstones in Xinjiang, China. Methods Blood samples were collected from 150 Uygur and Han patients with gallstones and 150 Uygur and Han individuals without ...

Case reports

Treatment of refractory hepatic hydrothorax by intrapleural injection of lauromacrogol: A case report

Changzhou LI, Jianhui LI, Xin HAO, Haibin JIANG, Aimin WANG, Haiyang HUA, Jing QI, Jingzhe ZHANG

2021, 37(9): 2177-2179. DOI: 10.3969/j.issn.1001-5256.2021.09.033

Abstract(494)

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Abstract:

Primary hepatic carcinosarcoma with hepatocellular carcinoma: A case report

Ri LI, Huaibin GUO, Ze LIANG, Na LI, Junye WEN, Wanxing ZHANG

2021, 37(9): 2180-2182. DOI: 10.3969/j.issn.1001-5256.2021.09.034

Abstract(763)

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A case of type 2 diabetes with glycogenic hepatopathy

Renshu MA, Tong WU, Ge YU, Ying CONG, Guijie XIN

2021, 37(9): 2183-2184. DOI: 10.3969/j.issn.1001-5256.2021.09.035

Abstract(379)

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A case of Alagille syndrome

Shan TANG, Li BAI, Wenyan SONG, Chen LIANG, Jie BAI, Sujun ZHENG

2021, 37(9): 2185-2187. DOI: 10.3969/j.issn.1001-5256.2021.09.036

Abstract(552)

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Abstract:

Yuxiang ZHAO, Lei JIA, Haiyang LI

2021, 37(9): 2188-2190. DOI: 10.3969/j.issn.1001-5256.2021.09.037

Abstract(606)

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Abstract:

Reviews

Research advances in hepatitis B virus and ubiquitination of related proteins

Wenhui TU, Jin LIU, Chuanwu ZHU

2021, 37(9): 2191-2197. DOI: 10.3969/j.issn.1001-5256.2021.09.038

Abstract(528)

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Abstract:
Protein ubiquitination is widely observed in cells and is a modification after protein translation. Hepatitis B virus (HBV) and ubiquitination of related proteins have attracted more and more attention. This article reviews HBV and the ubiquitination of related proteins, so as to provide a reference...

Research advances in monomers of Chinese herbs in treatment of liver fibrosis by regulating oxidative stress

Zhiwen ZHOU, Shan LI, Xianghua LIU, Ningning LI, Ning SUN, Baoping LU

2021, 37(9): 2198-2202. DOI: 10.3969/j.issn.1001-5256.2021.09.039

Abstract(782)

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Abstract:
Liver fibrosis, a common pathological process of most types of chronic liver diseases, is caused by the excessive deposition of extracellular matrix proteins after chronic liver injury. An increasing number of evidence has shown that oxidative stress is closely associated with the development and pr...

Association between YKL-40 and liver fibrosis

Jiawei SHI, Jing HUANG

2021, 37(9): 2203-2205. DOI: 10.3969/j.issn.1001-5256.2021.09.040

Abstract(691)

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Abstract:
YKL-40 is an emerging inflammatory marker with the highest expression level in the liver. This article summarizes the research advances in YKL-40 as a serological marker for liver fibrosis. The analysis shows that YKL-40 can effectively evaluate the severity of liver fibrosis and thus holds promise ...

Application of metagenomic next-generation sequencing in sepsis in liver cirrhosis

Xiaoge BEI, Jinjun CHEN, Beiling LI

2021, 37(9): 2206-2209. DOI: 10.3969/j.issn.1001-5256.2021.09.041

Abstract(686)

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Abstract:
Due to persistent systemic inflammation and immunosuppressive conditions, patients with liver cirrhosis are susceptible to bacterial infection, which may progress to sepsis without proper control. Early effective antibiotic therapy is the key to improving the prognosis of patients with sepsis. This ...

Role of N6-methyladenosine in the development and progression of hepatocellular carcinoma

Ke MA, Lijin ZHAO

2021, 37(9): 2210-2214. DOI: 10.3969/j.issn.1001-5256.2021.09.042

Abstract(564)

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Abstract:
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has relatively high incidence and mortality rates. Abnormal modification of N6-methyladenosine (m6A) may promote the development and progression of HCC. This article describes the structure and function of m6A and sum...

Research advances in extrahepatic diseases associated with nonalcoholic fatty liver disease

Luying ZHU, Yuchen LI, Lihua DENG, Jingtong WANG

2021, 37(9): 2215-2219. DOI: 10.3969/j.issn.1001-5256.2021.09.043

Abstract(1447)

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Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver diseases worldwide and covers a series of pathological manifestations from hepatic steatosis to inflammation, fibrosis, and even liver cirrhosis. NAFLD is associated with a wide range of extrahepatic diseases, including metab...

Research advances in autophagy-related signal molecules in nonalcoholic fatty liver disease

Jingxia HE, Xiuqin AN, Jinchun LIU

2021, 37(9): 2220-2224. DOI: 10.3969/j.issn.1001-5256.2021.09.044

Abstract(784)

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Abstract:
Nonalcoholic fatty liver disease (NAFLD) has become one of the main causes of chronic liver diseases worldwide and is closely associated with metabolic syndrome. In-depth studies on the pathogenesis of NAFLD in recent years have shown that autophagy is a highly conservative process in eukaryotes and...

Association of circadian rhythm and related genes with nonalcoholic fatty liver disease

Chenlu ZHAO, Wenxia ZHAO

2021, 37(9): 2225-2230. DOI: 10.3969/j.issn.1001-5256.2021.09.045

Abstract(763)

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Abstract:
The association between circadian rhythm and metabolic diseases has attracted more and more attention in recent years. A large number of clinical studies have shown that people who often stay up late or work in shifts have a significantly higher risk of nonalcoholic fatty liver disease than those wi...

Role of intestinal flora in metabolic-associated fatty liver disease

Lidan YANG, He HE, Zhenmei AN

2021, 37(9): 2231-2235. DOI: 10.3969/j.issn.1001-5256.2021.09.046

Abstract(783)

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Abstract:
In recent years, more and more studies have shown that intestinal flora is critical to the development and progression of metabolic-related fatty liver disease (MAFLD). This article summarizes MAFLD-related intestinal flora and metabolites and their possible mechanisms of action in disease process. ...

Research advances in the association between activating transcription factor 3 and chronic liver diseases

Qunli GU, Hui LI, Xiuxiu DENG, Zijian ZENG, Haijian DONG

2021, 37(9): 2236-2240. DOI: 10.3969/j.issn.1001-5256.2021.09.047

Abstract(844)

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Abstract:
Activating transcription factor 3 (ATF3) belongs to the transcription factor ATF/CREB family and is a stress-induced adaptive response gene. ATF3 is involved in the regulation of various cell activities to adapt to the changes in intracellular and extracellular environments. Recent studies have show...

Role of miRNA in the development and progression of cholangiocarcinoma

Sheng CHEN, Guoxiang CHEN, Zhongming HE, Shujie CHENG, Jisen ZHAO

2021, 37(9): 2241-2245. DOI: 10.3969/j.issn.1001-5256.2021.09.048

Abstract(654)

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Abstract:
Cholangiocarcinoma is the most common malignant tumor of the biliary tract, with a relatively high mortality rate and an incidence rate increasing year by year. Due to atypical symptoms in the early stage and complex anatomical location, it is often difficult for patients with cholangiocarcinoma to ...

New advances in the treatment of pancreatic cancer by targeting tumor microenvironment

Feiyu ZHANG, Yakepu ADILA, Jinming ZHAO, Yanhang GAO

2021, 37(9): 2246-2248. DOI: 10.3969/j.issn.1001-5256.2021.09.049

Abstract(922)

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Abstract:
Pancreatic cancer is the malignant tumor of the digestive tract with the lowest 5-year survival rate, and current first-line treatment regimens cannot significantly improve the overall prognosis of patients, so it is necessary to explore new treatment methods. A large number of studies have shown th...