Primary liver cancer has the second highest fatality among malignant tumors in China,and in our country,most cases of liver cancer occur on the basis of liver cirrhosis. In view of the clinical characteristics of primary liver cancer in China,we need to make full use of effective therapies in Wester...

The traditional Chinese medicine( TCM) constitution theory is an important means to reveal the host's genetic characteristics from the perspective of TCM. The types of constitution can influence liver pathological changes and the prognosis of disease in patients with chronic hepatitis B virus infect...

Accumulating evidence has shown that neutrophil- lymphocyte ratio( NLR),as an assessment index for inflammatory response,is closely related to the prognosis of various malignant tumors. This article summarizes the research advances in the relationship of NLR with overall survival,disease- free survi...

Objective To investigate the efficacy of Baihe Xiaoyao powder in patients with chronic hepatitis B( CHB) and depression,and to explore its mechanism of action from the perspectives of endocrine and immune function. Methods A total of 120 patients with CHB who visited the Outpatient Department of Zhe...

Objective To investigate the possible mechanism of“treating liver by nourishing spleen”in the treatment of liver fibrosis with reference to the effect of Xiaoyao powder and its separated recipe on gut microbiota and the level of portal endotoxins. Methods A total of70 healthy Wistar rats were random...

Objective To summarize the traditional Chinese medicine( TCM) deficiency and excess attributes in patients with HBV- related acute- on- chronic liver failure( HBV- ACLF),and to analyze its association with the phenotype of dendritic cells( DCs) and T lymphocyte subsets. Methods The basic information...

Objective To investigate the protective effect of Cordyceps militaris polypeptide against acute alcoholic liver injury in rats and related mechanism. Methods A total of 60 Wistar rats were randomly divided into blank control group,model group,and low-,medium-,and high- dose Cordyceps militaris polyp...

To investigate the effect of ultrasound- guided percutaneous injection of cinobufotalin or anhydrous ethanol in the treatment of portal vein tumor thrombus( PVTT) through a comparative analysis. Methods A total of 56 patients with PVTT after liver cancer surgery,who were admitted to the 94 th Hospit...

Objective To investigate the effects of early intervention with Huoxueqingjie decoction on hemorheological parameters and the levels of thromboxane A_2( TXA_2) and prostaglandin I_2( PGI_2) in patients with severe acute pancreatitis. Methods A total of 50 patients with severe acute pancreatitis( SAP...

Objective To investigate the influence of pegylated interferonα- 2a( PEG- IFNα- 2a) versus telbivudine( Ld T) on renal function in patients with chronic hepatitis B( CHB). Methods The clinical data of 92 previously untreated HBe Ag- positive CHB patients who participated in the CHB IV clinical trial...

Objective To investigate the efficacy of add- on adefovir dipivoxil( ADV) at week 12 /24 in HBe Ag- positive chronic hepatitis B( CHB) patients with hepatitis B virus( HBV) DNA levels of ≥105copies / ml during pegylated interferonα( PEG- IFNα) therapy.Methods A retrospective analysis was performed o...

Objective To investigate the efficacy of peginterferon alfa- 2a( PEG- IFN α- 2a) in the treatment of HBe Ag- positive chronic hepatitis B( CHB) resistant to multiple nucleos( t) ide analogues( NAs). Methods A total of 120 patients with HBe Ag- positive CHB resistant to multiple nucleos( t) ide analo...

Objective To investigate the value of HBs Ag quantification in predicting the prognosis of patients with chronic severe hepatitis B. Methods The clinical data of 61 patients with chronic severe hepatitis B who were admitted to The First Hospital of Jilin University from January 2012 to August 2015 w...

Objective To investigate the clinical characteristic and long- term prognosis risk factor of patients with hepatitis B virus- related acute- on- chronic liver failure( HBV- ACLF). Methods The clinical data of 1116 HBV- ACLF patients who were hospitalized in Southwest Hospital of Third Military Medic...

Objective To investigate the clinical features of acute hepatitis B( AHB) and acute exacerbation of chronic hepatitis B( CHB)for differential diagnosis. Methods A retrospective analysis was performed on the clinical data of 96 AHB patients and 124 patients with acute exacerbation of CHB,who were adm...

Objective To investigate the incidence of natural resistance mutations to direct- acting antiviral agents( DAAs) in patients with chronic hepatitis C( CHC) in Beijing,China,and to compare the natural resistance mutations to DAAs in interferon( IFN) / ribavirin( RBV) treatment- experienced and treatm...

Objective To investigate the relationship between small intestinal bacterial overgrowth( SIBO) and the severity of hepatitis B cirrhosis. Methods Forty- seven patients with hepatitis B cirrhosis who visited Department of Gastroenterology,Zhengzhou People's Hospital,from June 2014 to June 2015 were s...

Objective To investigate the efficacy of terlipressin and double- dose octreotide in reducing hepatic venous pressure gradient( HVPG) in patients with liver cirrhosis. Methods A total of 41 patients who were diagnosed with liver cirrhosis and esophageal and gastric varices in our hospital from June ...

Objective To determine the reference range of liver stiffness in healthy population,and to investigate the influence of age and sex on liver stiffness. Methods A total of 1794 healthy subjects who underwent physical examination in China National Petroleum Corporation Central Hospital from October 1,...

Objective To investigate and compare the clinical features of drug- induced liver injury( DILI) and primary biliary cirrhosis( PBC). Methods A total of 116 PBC patients and 124 DILI patients who were diagnosed in Shengjing Hospital of China Medical University from January 2005 to December 2013 were ...

Objective To investigate the clinical and pathological features of cryptogenic liver cancer,and to determine its etiology and pathogenesis. Methods A total of 22 patients with cryptogenic liver cancer who underwent surgical treatment in China- Japan Union Hospital of Jilin University from January 20...

Objective To investigate the safety,feasibility,and efficacy of total laparoscopic hepatectomy in the treatment of hepatocellular carcinoma( HCC) in the left lateral lobe. Methods A case- matched analysis was performed between 25 patients with HCC in the left lateral lobe confirmed by postoperative ...

Objective To measure the expression of NOB1 in liver cancer tissues,and to investigate the relationship between NOB1 and clinicopathological features of liver cancer. Methods A total of 48 liver cancer samples were collected from the patients who underwent liver cancer surgery in our hospital from F...

Objective To investigate the efficacy of raltitrexed combined with transcatheter arterial chemoembolization( TACE) in the treatment of advanced colorectal cancer with liver metastasis. Methods A total of 80 patients with liver metastasis of advanced colorectal cancer who were admitted to Central Hos...

Objective To investigate ultrasonographic signs as the factors for the recurrence of gallstones and polypoid lesion of the gallbla-dder in patients undergoing gallbladder- preserving surgery. Methods Related signs including gallbladder size,sound transmission of the gallbladder,gallbladder wall thic...

Objective To compare the clinical effect between laparoscopic retrograde cholecystectomy and partial cholecystectomy in the treatment of patients with complex bile duct diseases. Methods The clinical data of 83 patients with bile duct diseases who were diagnosed and treated in Guangyuan Mental Healt...

Objective To investigate the surgical treatment and prognosis of T1 b unsuspected gallbladder carcinoma( UGC). Methods Twenty- two patients with T1 b UGC admitted to our hospital were enrolled as subjects. The information on clinical pathology,radiological examination,laboratory tests,surgical treat...

Objective To investigate the method and efficacy of cholelithotomy by laparoscopy and cholangioscopy,a controversial therapy for cholecystolithiasis. Methods Forty- eight patients with cholecystolithiasis who were admitted to our hospital and treated with gallbladder- preserving cholelithotomy by la...

Objective To compare the efficacy of three liver- protecting drugs commonly used in the treatment of drug- induced liver injury. Methods The clinical data of 90 patients with drug- induced liver injury who were treated in Yingcheng People's Hospital from November 2012 to April 2015 were analyzed ret...

Objective To analyze the clinical data of Klebsiella pneumoniae liver abscess( KPLA),and to provide a reference for early diagnosis and proper treatment. Methods The etiological features of 156 patients with bacterial liver abscess( BLA) and positive culture results who were hospitalized in The Firs...

Objective To investigate the mechanism of action of PNPLA3 I148 M mutation in the development and progression of non- alcoholic fatty liver fibrosis. Methods The lentiviral vectors carrying the mutant or wild- type PNPLA3 I148 M gene were constructed and transfected into rat hepatic stellate( HSC- T...

In recent years,great progress has been made in the external treatment of traditional Chinese medicine( TCM) for cirrhotic ascites,including TCM umbilical compress therapy,TCM enema,acupuncture,moxibustion,and light therapy. The external treatment has similar effects as oral administration of TCM in...

Ophiacordyceps sinensis has been used as a traditional natural drug for at least 600 years. It has various pharmacological activities and has been widely used in clinical practice. This article summarizes the research on the pharmacological effects of Ophiacordyceps sinensis in liver diseases and po...

In recent years,new changes have occurred in the treatment of chronic hepatitis C. Direct- acting antiviral agents have shown powerful efficacy in the treatment of active hepatitis C,and even refractory hepatitis C shows a high continuous virologic response. Among these direct- acting antiviral agen...

Primary biliary cirrhosis( PBC) is a chronic cholestatic liver disease,characterized by progressive non- pyogenic inflammation in the small intrahepatic bile ducts,and can cause hepatic fibrosis and liver cirrhosis. The etiology and pathogenesis of PBC remain unknown. The development and progression...

In recent years,studies have shown that the expression of pyruvate kinase muscle isozyme 2( PKM2) is increased significantly in various tumor cells. PKM2 acts like a signal molecule in tumor cells and participates in the expression and regulation of genes related to tumor cell proliferation,cell aut...

Currently,sorafenib is the multi- target inhibitor for the treatment of advanced primary liver cancer,and can effectively prolong the progression- free survival and overall survival in patients with advanced primary liver cancer. The application of sorafenib in the targeted therapy for liver cancer ...