Thermal ablation ranks along with surgical resection and liver transplantation as a major radical treatment for liver tumor, and more and more attention has been paid to its efficacy and minimal invasiveness.However, the majority of Chinese patients who need ablation treatment have poor liver functi...

Image-guided local thermal ablation plays an increasingly important role in the treatment of live cancer, and the safety of this therapy deserves some attention. The major complications of thermal ablation include bleeding, biliary complications, gastrointestinal perforation, infection, thoracic and...

The recent progress in radiofrequency ablation (RFA) of hepatic hemangioma was reviewed, with a focus on radiofrequency electrodes, treatment modalities, complications, and prevention strategies.The foundation for the standardization of RFA of hepatic hemangioma was laid.The standardization of RFA w...

Imaging evaluation of hepatic malignancies after ablation is an important clinical problem to be solved.Contrast enhanced ultrasound (CEUS) is a noninvasive, safe technique for acquiring the microcirculation information of treatment areas.The CEUS technique and the findings of local and distant recu...

Liver function is an important influential factor for the treatment outcome and prognosis of patients with hepatocellular carcinoma (HCC) following radiofrequency ablation (RFA) and should be evaluated before operation. In order to demonstrate the clinical significance of liver function evaluation b...

Primary hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver.Accurate assessment of treatment outcome and prognosis in HCC patients is very important due to its high malignancy and poor prognosis.Currently, radiological imaging, though a standard method for prognostic evalu...

Advanced oxidation protein products (AOPP) are a class of oxidatively modified proteins closely associated with inflammation and oxidative stress. The progress in research on AOPP in liver diseases and discusses the source, biochemical characteristics, and biological effects of AOPP and its associat...

Objective To compare clinical efficacy and recurrence between surgical resection and radiofrequency ablation (RFA) in the treatment of small hepatocellular carcinoma (HCC) .Methods The clinical data of 97 patients with small HCC, who underwent surgical resection or RFA as the initial treatment in Th...

Objective To compare the clinical effects of radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) in treating postoperative recurrence of hepatocellular carcinoma (HCC) and to provide reference for clinical treatment of recurrent HCC. Methods A retrospective analysis was performed ...

Objective To evaluate the clinical efficacy of transarterial chemoembolization (TACE) combined with microwave coagulation therapy (MCT) in the treatment of advanced liver cancer and to provide a more convincing basis for the clinical application of this therapy.Methods A search was performed using C...

Objective To evaluate the efficacy and safety of telbivudine given from the 12th week of gestation in preventing mother-to-infant transmission of hepatitis B virus (HBV) in pregnant women with high HBV DNA load.Methods Eighty pregnant women (at 12 weeks of gestation) with chronic hepatitis B, who ha...

Objective To investigate the efficacy of nucleoside analogue-based salvage therapy in patients with chronic hepatitis B (CHB) with multidrug resistance (MDR). Methods Twenty-seven CHB patients with MDR were divided into three equal groups for receipt of salvage therapy with: tenofovir (TDF) plus ent...

Objective To retrospectively analyze the therapeutic effect of antiviral therapy in the chronic hepatitis B (CHB) patients with nonalcoholic fatty liver disease (NAFLD) and to investigate whether hepatocyte steatosis affects the response to antiviral therapy in CHB patients.Methods A total of 110 CH...

Objective To evaluate the expression of glucokinase (GCK) mRNA and glucose transporter-2 (GLUT2) in the liver tissues of patients with severe chronic hepatitis B and to preliminarily investigate their roles in abnormal glucose metabolism among patients with severe chronic hepatitis B.Methods The exp...

Objective To observe the expression of endogenous cannabinoid receptor l (CB1) in rats with non-alcoholic fatty liver disease (NAFLD) and to preliminarily investigate the role of CB1 receptors in the pathogenesis of NAFLD. Methods Forty-eight male SD rats were randomly divided into three groups: con...

Objective To evaluate the chemosensitivities of hepatocellular carcinoma (HCC) to different chemotherapy drugs by 3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyl-2H tetrazolium bromide (MTT) assay and to provide guidance for individualized chemotherapy regimen in regional chemotherapy via the hepatic ...

Objective To investigate the expression of DNA methyltransferases (DNMTs) in cancerous tissues, paracancerous tissues, and cirrhotic tissues among patients with liver cancer and to analyze the relationship between HBV infection and DNMT expression.Methods Forty-four samples were divided into HBV inf...

Objective To evaluate the abnormal methylation of p14, p15, p16, and RB in the cancerous tissues of liver cancer patients and to investigate the significance of detection of multigene methylation for the early diagnosis of liver cancer. Methods Methylation-specific PCR was used to evaluate the methy...

Objective To evaluate the relation of serum cystatin C (CysC) and urotensin II (uII) levels with presence of hepatorenal syndrome in patients with decompensated liver cirrhosis to determine the diagnostic potential for these serum markers in order to facilitate early detection of hepatorenal syndrom...

Liver biopsy (LB) is considered the gold standard for assessing the pathological damage of the liver in nonalcoholic fatty liver disease (NAFLD) , but this technique is not widely applied in clinical diagnosis because it is invasive.Rapid progress has been made in the research on the methods for non...

The key step in the pathogenesis of hepatic fibrosis is the activation of hepatic stellate cells (HSCs) into fibroblasts and the abnormal expression of extracellular matrix (ECM) after activation.The important role of Rho/ROCK signaling pathway in the activation of HSCs is reviewed.It is summarized ...