Preventive effects of blueberry on hepatic injury by downregulating the expression of TLR4

Jiang PingPing; Zhang Quan; Wang YuPing; Wang Hui; Cheng MingLiang

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May 2012

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Article Navigation > Journal of Clinical Hepatology > 2012 > 28(5): 380-382+394

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Preventive effects of blueberry on hepatic injury by downregulating the expression of TLR4

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Published Date: 2012-05-20

Abstract

Abstract

Objective To study the effect of Blueberry against acute hepatic injury induced by CCL4 and on the expression of TOLL-like receptor 4 (TLR4) .Methods fourty-eight rats were divided into five groups including control group (group A) , acute CCl4 induced liver injury group (group B) , blueberry low-dose group (group C) , blueberry high-dose group (group D) and thymosin group (group E) .Group C and group D were gavaged with blueberry juice 0.5 ml/ 100 g, 1.0 ml/100 g.The liver index, the level of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected after rats were killed at the end of the experiments.TLR4 protein level of liver was detected by Western blotting.Results The liver index (0.047 30±0.002 85) , serum ALT and AST levels (4536.00±535.39, 7959.33±108.89) in group B was higher than that in group A (P<0.05) .While he liver index (0.040 80±0.003 77, 0.040 80±0.003 81) , serum ALT and AST levels (2138±980.32;4049.67±466.01, 1247.00±609.00, 2063.33±1357.32) in group C and D was lower than that in group B (P<0.05) .Compared with group A, the protein expressions of TLR4 were higher (the ratio to β-actin were 1.392±0.204, P<0.05) in groups B, and the protein expressions of TLR4 in group C and D were lower than that of group B (C:1.273±0.203, D:1.110±0.168, E:0.943±0.161, P<0.05) .Conclusion Blueberry may have protective effects on CCl4-induced hepatic injury by reducing the expression of TLR4.
- blueberry,
- liver injuries,
- Toll-like receptor 4

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References

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Preventive effects of blueberry on hepatic injury by downregulating the expression of TLR4

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Preventive effects of blueberry on hepatic injury by downregulating the expression of TLR4

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