Association between the type Ⅰinterferon receptor promoter gene and treatment response to antivirus in patients with chronic hepatitis C

Zhou Li; Qie ChunHua; Guo Jie; Lu Wei; Wang Yi; Gao Min; Lu ChengZhen; Han Xu; Zhai Lu

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May 2012

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Association between the type Ⅰinterferon receptor promoter gene and treatment response to antivirus in patients with chronic hepatitis C

Published Date: 2012-05-20

Abstract

Abstract

Objective To investigate the association between polymorphisms of type Ⅰinterferon receptor (IFNAR1) promoter gene and the treatment response to interferon alpha (IFNα) in patients with chronic hepatitis C (CHC) .Methods 73 CHC patients who consented to receive pegylated IFNα in combination with ribavirin therapy were enrolled in this study.The treatment responses were monitored.The subjects were divided into two groups as response and no response.Meanwhile, the genes of IFNAR1 promoter in these patients were sequenced.Measurement data were analyzed by t test and enumeration data were analyzed by Chi square test.Results 47 patients achieved response and 26 patients had no response.Polymorphisms were identified in IFNAR1 promoter gene, which include G/C substitution at locus-568, C/T substitution at locus-408, C/T substitution at locus-3 and GT microsatellite repeat sequence at locus-77.The response rate to antivirus therapy in CHC patients with haplotype non-568C/-408C/-77 (GT) 5/-3C was higher than that in patients with haplotype-568C/-408C/-77 (GT) 5/-3C (77.1% vs 52.6%, χ2=4.773, P=0.029) .The response rate to antivirus therapy in CHC patients with haplotype-568C/-408T/-77 (GT) 5/-3T was higher than that in patients with haplotype non-568C/-408T/-77 (GT) 5/-3T (90.9% vs 59.7%, χ2=3.92, P=0.048) .Conclusion Polymorphisms of IFNAR1 promoter gene are associated with the treatment response to IFNα in CHC patients.
- hepatitis C,
- chronic,
- receptor

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Association between the type Ⅰinterferon receptor promoter gene and treatment response to antivirus in patients with chronic hepatitis C

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Association between the type Ⅰinterferon receptor promoter gene and treatment response to antivirus in patients with chronic hepatitis C

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