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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2012
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The immune pathogenesis of nonalcoholic steatohepatitis

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  • Published Date: 2012-05-20
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    [4]Zhan YT, An W.Roles of liver innate immune cells in nonal-coholic fatty liver disease[J].World J Gastroenterol, 2010, 16 (37) :4652-4660.
    [5]Koek GH, Liedorp PR, Bast A.The role of oxidative stress innon-alcoholic steatohepatitis[J].Clin Chim Acta, 2011, 412:1297-1305.
    [6]Otagawa K, inoshita K, Fujii H, et al.Erythrophagocytosis byliver macrophages (Kupffer cells) promote oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis[J].Am J Pathol, 2007, 170 (3) :967-980.
    [7]CaniPD, Amar J, Iglesias MA, et al.Metabolic endotoxemiainitiates obesity and Insulin resistance[J].Diabetes, 2007, 56 (7) :1761-1772.
    [8]Tilg H.The Role of Cytokines in non-alcoholic fatty liver dis-ease[J].Dig Dis, 2010, 28 (1) :179-185.
    [9]Adler M, Taylor S, Ckebugeu K, et al.Intrahepatic natural killerT cell populations are increased in human hepatic steatosis[J].World J Gastroenterol, 2011, 17 (13) :1725-1731.
    [10]Maher JJ, Leon P, Ryan JC.Beyond insulin resistance:In-nate immunity in non-alcoholic steatohepatitis[J].Hepatol-ogy, 2008, 48 (2) :670-678.
    [11]Kremer M, Thomas E, Milton RJ, et al.Kupffer cell and In-terleukin-12-Dependent loss of nature killer T cell in hepa-tosteatosis[J].Hepatology, 2010, 51 (1) :130-141.
    [12]Ma X, Hua J, Li Z.Probiotics improve high fat diet-inducedhepatic steatosis and insulin by increasing hepatic NKT cells[J].Hepatology, 2008, 49 (5) :821-830.
    [13]Kahraman A, Schlattjan M, Kocabayoglu P, et al.Major his-to-compatibility complex class I-related chains A and B (MIC A/B) :a novel role in nonalcoholic steatohepatitis[J].Hepatology, 2010, 51 (1) :92-102.
    [14]Rada eva S, Sun R, Jaruga B, et al.Natural killer cells amel-iorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners[J].Gastroenterology, 2006, 130 (2) :435-452.
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    [22]Ma X, Hua J, Mohamood AR, et al.A High-Fat Diet andRegulatory T cell influence susceptibility to endotoxin-in-duced liver injury[J].Hepatology, 2007, 46:1519-1529.
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