The changes and value of the proportion of CD4+CD25+ regulatory T cells in HBeAg (+) and HBeAg (-) ASC in peripheral blood

Wu YinYa; Tan ShanZhong; Zhao Lei; Sun WeiWei; Shen JianJun; Liang ZhongFeng

Issue 3

Mar. 2012

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2012 > 28(3): 209-211

PDF( 172 KB)

The changes and value of the proportion of CD4+CD25+ regulatory T cells in HBeAg (+) and HBeAg (-) ASC in peripheral blood

Research funding:

Published Date: 2012-03-20

Abstract

Abstract

Objective To investigate the Changes and Value of the Proportion of CD4+CD25+regulatory T cells (Treg) in HBeAg (+) and HBeAg (-) chronic asymptomatic hepatitis B virus carriers (ASC) .Methods Patients with HBeAg (+) ASC (n=50) , HBeAg (-) ASC (n=50) and normal subjects (n=20) were recruited in this study.Flow cytometric analysis was used to detect the quantification of peripheral CD3+, CD4+ and CD8+T lymphocyte subgroup, CD4+CD25+Treg.Results The proportion of CD3+, CD4+, CD8+T lymphocyte subgroup has no significant difference among healthy controls, HBeAg (+) and HBeAg (-) ASC.The ratio of CD4 and CD8 in HBeAg (+) patients was elevated, but there was no significant difference between healthy controls and HBeAg (+) patients.Contrast to normal subjects, the ratio of CD4+CD25+Treg increases in HBeAg (+) ASC, but decreases obviously in HBeAg (-) ones (P<0.05) .Conclusion Although having normal hepatic function, HBeAg (+) and HBeAg (-) ASC have different ratio of peripheral CD4+CD25+Treg, Our findings suggest that HBeAg (+) and HBeAg (-) ASC stand in different immune state.
- hepatitis B,
- chronic,
- T-lymphocytes

FullText(HTML)

References(12)

References

[1]Sakaguchi S, Sakaguchi N, Shimizu J, et al.Immunologic toler-ance maintained by CD25+CD4+regulatory T cells:their com-mon role in controlling autoimmunity, tumor immunity, andtransplantation tolerance[J].Immunol Rev, 2001, 182:18-32.

[2] 中华医学会.慢性乙型肝炎防治指南 (2010年版) [J].临床肝胆病杂志, 2011, 27 (1) :1-15.

[3]Peng G, Li S, Wu W, et al.Circulating CD4+CD25+regula-tory T cells correlate with chronic hepatitis B infection[J].Immunology, 2008, 123 (1) :57-65.

[4]Stoop JN, vander-Molen RG, Baan CC, et al.Regulatory Tcells contribute to the impaired immune response in patientswith chronic hepatitis B virus infection[J].Hepatology, 2005, 41 (4) :700-702.

[5]Sun XH, Liu QL, Li M, et al.The study of CD4+and CD8+:T subsets in chronic hepatitis B patients[J].Xi Bao Yu FenZi Mian Yi Xue Za Zhi, 2011, 27 (5) :545-547.

[6]Nan XP, Zhang Y, Yu HT, et al.Circulating CD4+CD25highregulatory T cells and expression of PD-1 and BTLA onCD4+T cells in patients with chronic hepatitis B virus infec-tion[J].Viral Immunol, 2010, 23 (1) :63-70.

[7]Franzese O, Kennedy PT, Gehring AJ, et al.Modulation ofthe CD8+-T-cell response by CD4+CD25+regulatory Tcells in patients with hepatitis B virus infection[J].J Virol, 2005, 79 (6) :3322-3328.

[8]詹爱琴, 刘佩芝, 杨勇.乙肝病毒感染者外周血CD4+CD25+调节性T细胞的表达及临床意义[J].临床肝胆病杂志, 2008, 24 (4) :652-654.

[9]刘佩芝, 詹爱琴, 季榕, 等.慢性乙型肝炎患者外周血CD4+CD25+调节性T细胞、白细胞介素-10水平及其临床意义[J].肝脏, 2009, 14 (4) :124-126.

[10]Zhang HH, Guo F, Fei R, et al.Inhibition of CD4+CD25+regulatory T cells in chronic hepatitis B patients[J].Zhong-hua Yi Xue Za Zhi, 2008, 88 (8) :511-515.

[11]Deng M, Li MH, Liu SA, et al.Studies about the level ofCD4+CD25+regulatory T cells and relation between expres-sion of Foxp3 and CD127 in peripheral blood of chronic HBVinfection[J].Zhonghua Shi Yan He Lin Chuang Bing Du XueZa Zhi, 2010, 24 (1) :21-23.

[12]Li X, Chen Y, Ma Z, et al.Effect of regulatory T cells andadherent cells on the expansion of HBcAg-specific CD8+Tcells in patients with chronic hepatitis B virus infection[J].Cell Immunol, 2010, 264 (1) :42-46.

Relative Articles

[1]	Guangjun TANG, Jing YOU, Huai'e LIU, Yujuan PENG. Role of T helper 17 cell/regulatory T cell imbalance in the progression of HBV-related liver diseases[J]. Journal of Clinical Hepatology, 2021, 37(2): 414-418. doi: 10.3969/j.issn.1001-5256.2021.02.035
[2]	Xue Miao, Mao XiaoRong, Chen Hong. Change in T helper 17 cell/regulatory T cell imbalance in rats with immunological liver injury[J]. Journal of Clinical Hepatology, 2020, 36(1): 149-152. doi: 10.3969/j.issn.1001-5256.2020.01.033
[3]	Wang Yan, Huang YouYing, Ma Yan, Guo Feng, Wang XiaoBo, Wang XiaoZhong. Expression features of follicular helper T cells in peripheral blood in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2018, 34(1): 58-62. doi: 10.3969/j.issn.1001-5256.2018.01.012
[4]	Wang HaiYan, Zhu Li, Wang YinLing, Zhu YuePing, Zhu XiaoYan, Chai XiaoZhe, Qian Feng, Li Ming, Zhu ChuanWu. Impact of pegylated interferon versus conventional interferon on the change in peripheral CD4+CD25highT cells in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2018, 34(1): 53-57. doi: 10.3969/j.issn.1001-5256.2018.01.011
[5]	Chen Bin, Zhang Tao, Zhu WenFang, Peng Jie, Zhang QianQian, Li YunFang, Ding XiuLi. Effect of the warming and heat-clearing method on the percentage of regulatory T lymphocytes/T helper 17 cells in rats with acute-on-chronic liver failure[J]. Journal of Clinical Hepatology, 2018, 34(12): 2642-2647. doi: 10.3969/j.issn.1001-5256.2018.12.026
[6]	Gao WeiHua, Ge KuanXue, Xiang XiaoXing. Association of Th17 cells, regulatory T cells, and their imbalance with nonalcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2018, 34(6): 1347-1350. doi: 10.3969/j.issn.1001-5256.2018.06.046
[7]	Li Yu, Tian Ying, Yang XiaoMei, Cao NingJia, Li Zhu, Zhang Hong, Zhang XianJiao. Effect of thymosin α1 on the function of CD4+CD25+CD127dim/- regulatory T cells in chronic hepatitis B patients[J]. Journal of Clinical Hepatology, 2018, 34(5): 1011-1014. doi: 10.3969/j.issn.1001-5256.2018.05.017
[8]	Ge KuanXue, Gao WeiHua, Xiang XiaoXing. Association of regulatory T cells, T helper 17 cells, and change in their balance with autoimmune hepatitis[J]. Journal of Clinical Hepatology, 2018, 34(7): 1573-1576. doi: 10.3969/j.issn.1001-5256.2018.07.045
[9]	Guo FeiBo, Wu JunZhu, Ai LiMing, Song Ying. Clinical significance of Th17/Treg and associated cytokines in peripheral blood in chronic hepatitis C patients with liver cirrhosis[J]. Journal of Clinical Hepatology, 2017, 33(3): 479-484. doi: 10.3969/j.issn.1001-5256.2017.03.017
[10]	He JunNan, Zhao ShouSong. Research advances in association between regulatory T cells and hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2016, 32(2): 361-365. doi: 10.3969/j.issn.1001-5256.2016.02.036
[11]	Guo FeiBo. Change in peripheral blood CD4~+ regulatory T cells and its association with antiviral effect in patients with chronic hepatitis C[J]. Journal of Clinical Hepatology, 2016, 32(12): 2317-2321. doi: 10.3969/j.issn.1001-5256.2016.12.017
[12]	Zhou Yan, Jing Xiang, Zhu ZhengYan. Roles of regulatory T cells and T-helper cells in hepatitis B virus-related liver diseases[J]. Journal of Clinical Hepatology, 2016, 32(10): 1994-1997. doi: 10.3969/j.issn.1001-5256.2016.10.040
[13]	Li CaiDong, Chen XiLian, Tian PengFei, Li HuiJun, Wu Bin. Correlation analysis of percentages of T lymphocyte subsets and CD4~+CD25~+ regulatory T cells and HBV DNA level in peripheral blood of chronic hepatitis B patients[J]. Journal of Clinical Hepatology, 2015, 31(4): 541-545. doi: 10.3969/j.issn.1001-5256.2015.04.016
[14]	Xian YongChao, Cheng ShuQuan, Ni Hui, Huang ChengJun. Analysis of hepatic CD4~+,CD8~+,CD20~+,and CD57~+ T lymphocytes in chronic hepatitis B patients with different HBe Ag status[J]. Journal of Clinical Hepatology, 2015, 31(4): 546-550. doi: 10.3969/j.issn.1001-5256.2015.04.017
[15]	Cheng Ping, Xue BoYu. Research progress in Treg/Th17 imbalance in persistent HBV infection[J]. Journal of Clinical Hepatology, 2015, 31(4): 603-606. doi: 10.3969/j.issn.1001-5256.2015.04.031
[16]	Huang JinFa, Xu Tao, Pan XingNan, Lai XiaoHuan, Zheng LianQiu, Huang ZhiJie. Measurement of peripheral blood Treg,Tr1,and Th17 cells in patients with chronic hepatitis B and its clinical significance[J]. Journal of Clinical Hepatology, 2015, 31(4): 551-555. doi: 10.3969/j.issn.1001-5256.2015.04.018
[17]	Chen XiaoYun, Zhang YongHong, Ma LiNa, Jin Yi, Yu HaiBin, Zheng YanHong, Liu Ning, Liu JinHua, Wang Jian, Chen XinYue. Changes in NK cells and regulatory T cells among patients with refractory chronic hepatitis C during antiviral treatment[J]. Journal of Clinical Hepatology, 2014, 30(6): 508-513. doi: 10.3969/j.issn.1001-5256.2014.06.008
[18]	Chen HuiJuan, Zhao ShouSong. Recent insights into the roles of regulatory T cells in viral hepatitis[J]. Journal of Clinical Hepatology, 2012, 28(11): 868-871.
[19]	Jiang ShuLian, Tan ShanZhong, Wen Jian. Role of CD4+CD25+ T regulatory cells in HBeAg seroconversion during interferon antiviral[J]. Journal of Clinical Hepatology, 2012, 28(7): 528-530.
[20]	Liang YanXiu, Jiang JianNing, Su MingHua, Guo WenWen, Huang XiaoHong, Liu ZhiHong, Xie Rong, Fu WuDao, He LiXia, Zhong ShaoHua. Influence of HBeAg seroconversion on virological relapse in chronic hepatitis B patients on withdrawal of nucleos (t) ide analogues therapy[J]. Journal of Clinical Hepatology, 2011, 27(12): 1275-1277+1290.

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (295) PDF downloads(111)

The changes and value of the proportion of CD4+CD25+ regulatory T cells in HBeAg (+) and HBeAg (-) ASC in peripheral blood

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

The changes and value of the proportion of CD4+CD25+ regulatory T cells in HBeAg (+) and HBeAg (-) ASC in peripheral blood

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content