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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2012

Research advance of the apolipoproteinC-Ⅲ polymorphisms

  • Published Date: 2012-02-20
  • ApolipoproteinC-Ⅲ (APOC-Ⅲ) can affect lipid metabolism through inhibition of lipoprotein lipase (LPL) .Polymorphisms in the APOC-Ⅲ gene may affect the expression and function of the protein, thereafter interfering the lipid metabolism.The most famous single nucleotide polymorphisms (SNPs) are 3238C>G polymorphism (SstI site) in the 3'untranslated region, -482C>T and-455T>C polymorphisms in the insulin response element (IRE) of the promoter.There are strong associations between APOC-Ⅲ gene variants and diseases such as metabolic syndrome (MS) , coronary artery disease (CAD) and nonalcoholic fatty liver disease (NAFLD) .This review aims to summarize achievements and explore new ways for our future work.

     

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