Significance and expression of STAT3 in survivin primary gallbladder carcinoma

Objective To detect the expression of STAT3, p-STAT3 and Survivin in primary gallbladder carcinoma (PGC) and explore its significance in the occurrence and development of PGC.Methods The expression of STAT3, p-STAT3 and Survivin were determined in samples from 45 PGC tissues and corresponding nontumor tissues, 20 chronic cholecystitis by immunohistochemistry.The relationship between expressions of these proteins and clinicopathological factors, and its prognosis were analysed.Results The positive rates of STAT3, p-STAT3 and Survivin in 45 PGC tissues were 66.7% (30/45) , 55.6% (29/45) and 64% (25/45) respectively, which was significantly higher than those in 45 corresponding PGC nontumor tissues (P<0.01) and 20 chronic cholecystitis tissues (P<0.01) .The expression of survivin were positively correlated with STAT3 (r=0.558, P<0.01) , p-STAT3 (r=0.830, P<0.01) .The expressions of STAT3, p-STAT3 and Survivin were significantly associated with histopathological grades, lymph node metastasis, nevin stages and 3-year survival rate.Conclusion STAT3, p-STAT3 and Survivin may play a vital role in the occurrence and development of PGC.The expressions of STAT3, p-STAT3 or Survivin are the metastatic and prognostic factors in PGC.