中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2011

The expression and significance of HMGB1 in chronic hepatitis B

  • Published Date: 2011-08-20
  • Objective To investigate the expression of high mobility group box 1 protein (HMGB1) in different liver tissue and its relationship with liver injury.Methods 46 liver specimens of chronic hepatitis B (CHB) patients were diagnosed by serology test.The hepatic inflammation and fibrosis degree were tested by HE, Masson and Gordon-Sweet staining.Immunohistochemical method was used to detect the expression of HMGB1.Results HMGB1 didn't or weakly expressed in normal liver tissue, while strongly expressed along with aggravative hepatic inflammation and fibrosis (P<0.005) .Conclusion HMGB1 expression is positively correlated with hepatic inflammation and fibrosis, which is the sensitive indicator of treatment and prognosis.

     

  • [1]Wang H, Yang H, Tracey KJ.Extracellular role of HMGB1 in in-flammation and sepsis[J].J Intern Med, 2004, 255 (3) :320-331.
    [2]赵雷, 刘靖华, 唐靖, 等.人高迁移率族蛋白1的原核细胞表达及其功能研究[J].中国病理生理杂志, 2006, 22 (6) :1119-1123.
    [3] 中华医学会.慢性乙型肝炎防治指南[J].胃肠病学, 2006, 11 (9) :550-556.
    [4]中华医学会.病毒性肝炎防冶方案[J].中华肝脏病杂志, 2000, 8 (3) :324-329.
    [5]Ishak K, Bap tista A, Bianchi L, et al.Histological grading andstaging of chronic hepatitis[J].J Hepatol, 1995, 22 (4) :696-699.
    [6]Koichi S, Hiroya T, Akitoshi I, et al.High-mobility-group boxchromosomal protein 1 as a new target for modulating stress response[J].Surg Today, 2010, 40 (4) :592-601.
    [7]Hamada N, Maeyama T, Kawaguchi T, at al.The role of high mob-ility group box 1 in pulmonary fibrosis[J].Am J Respir Cell MolBiol, 2008, 39 (2) :440-447.
    [8]赵中夫, 韩德五.高迁移率族蛋白B-1及其在肝损伤合并内毒素血症中的作用[J].中华肝脏病杂志, 2006, 14 (9) :718-720.
    [9]刘洪波, 范学工, 黄建军, 等.乙型肝炎患者血清高迁移率蛋白-1含量的检测及临床意义[J].中华肝脏病杂志, 2007, 15 (11) :812-815.
    [10]刘洪波, 范学工, 刘悦晖, 等.肝损伤模型小鼠高迁移率族蛋白-1的表达[J].生命科学研究, 2008, 12 (2) :169-173.
    [11]Ayse A, Muhammet HU, Serkan C, et al.Is HMGB1 a new indi-rect marker for revealing fibrosis in chronic hepatitis and a new ther-apeutic target in treatment[J].Viral Immunol, 2010, 23 (6) :633-638.
    [12]Kao, Jawan B, Goto S, et al.High-mobility group box 1 pro-tein activates hepatic stellate cells in vitro[J].Transplant Proc, 2008, 40 (8) :2704-2705.
    [13]Sitia G, Iannacone M, Muller S, et al.Treatment with HMGB1 inhibi-tors diminishes CTL-induced liver disease in HBV transgenic mice[J].J Leukoc Biol, 2007, 81 (1) :100-107.
    [14]Jon C, Pinhua P, Rajeev D, et al.Cisplatin prevents high mobilitygroup box 1 release and is protective in a murine model of hepatic is-chemia/reperfusion injury[J].Hepatology, 2009, 50 (2) :565-574.
    [15] Koichi S, Hiroya T, Akitoshi I, et al.High-mobility-group boxchromosomal protein 1 as a new target for modulating stress response[J].Surg Today, 2010, 40 (3) :592-601.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (287) PDF downloads(138) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return