Relationship between serum visfatin and serum adiponectin level and the pathology of nonalcoholic fatty liver disease

Objective To explore the relationship between serum visfatin and adiponectin levels and the pathology of NAFLD.Methods 54 patients were divided into 3 groups according to the pathology, including control group, simple steatosis group, and nonalcoholic steatohepatitis group.Serum visfatin and adiponectin levels were measured by enzymelinked immunosorbent assay.Results Among the 54 patients, control group includes 23 cases;simple steatosis group comprises of 11 cases;while nonalcoholic steatohepatitis group contains 20 cases.The level of serum visfatin of NASH group is lower than that of control group and simple steatosis group.Moreover, the change of serum adiponectin of NASH is as same as serum visfatin.Conclusion In NAFLD patients, the more severe the changes of steatosis and inflammation of the histopathology in liver, the lower levels of visfatin and adiponectin in plasma concentrations were showed.