The prognostic assessment of model for end-stage liver disease (MELD) and total bile acids in patients with subacute liver failure

Objective To analyze the effect of combination of MELD with total bile acids on predicting the prognosis of subacute liver failure.Methods Serum CR, INR, TBil and TBA of 81 patients with subacute liver failure were detected and MELD scores were calculated by the formula.The single scores of MELD or total bile acids and the two kinds of scores together were compared.Results The level of MELD and total bile acids of patients in death group were higher than that in survival group (P<0.05) .There were significant differences in the mortality of the MELD and serum TBA in respective groups (P<0.01) .Predicting the death prognosis with MELD≥30 and TBA≥200, the sensitivity and the specificity can reach 67.65℅ and 97.37℅ respectively.There was a positive correlation between serum TBA and MELD (r=09903, P<0.01) .Conclusion MELD and total bile acids improves the accuracy of prognosis for patients with subacute liver failure.