Objective To evaluate the management of chronic hepatitis C with PEG-IFNα-2a and ribavirin.Methods We retrospectively analyzed the virological response of 58 patients with different genotypes of hepatitis C virus (HCV) after anti-HCV management.Among them, 43 cases experienced HCV genotype 1 infection, and 15 cases were infected with genotype 2.All the Patients were assigned for PEG-IFN α-2a combined ribavirin for 48 weeks, HCV RNA was tested before treatment, 12 and 24 weeks post management, at the end of treatment, 24 and 48 weeks after treatment was terminated.Results The rapid virological responses of the genotype 1 patients was 48.8%, obviously lower than the genotype 2 (80%, P<0.05) .After 48 weeks of termination of treatment, there were significant deviation of 53.5, and 86.7% (P<0.05) , respectively between the two genotypes.The rapid virological responses for the patients with high viral load and lower viral load were about 46.2% and 93.8% (P<0.05) , respectively.Obvious deviation was observed between them at the point of 48 weeks after treatment termination, they were 51.3% and 84.2% (P<0.05) .Conclusion PEG-IFNα-2a in combination with ribavirin can effectively treat patients with different genotypes of HCV.The efficacy is better for genotype 2 than 1, and patients with low viral load than high viral load.
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