The analysis of turnover among serum total bile acid levels in hepatitis during pregnancy

Objective To observe the impact of value of total bile acid(TBA) on fetus in the different types of hepatitis during pregnancy,and to provide the reference for diagnosis and treatment.Methods Compare liver biochemical test and clinical outcome between the pregnant hepatitis and non pregnant hepatitis B patients.The impact of TBA level on neonatal was evaluated by comparing abnormal TBA in pregnant female and Apgar score.Results All liver biochemical indicators and TBA levels have no statistical differences between the different stages of pregnant hepatitis patients and the viral hepatitis patients(P<0.05).In the pregnant hepatitis and non pregnant hepatitis B patients,the levels of TBA,ALT,AST and TBil were positively correlated(P<0.01).Neonatal Apgar score had significant differences between TBA abnormal(TBA≥50 μmol/L) and TBA normal pregnancy group(P<0.01).Many cases of newborns with low scores were ensured to be obstetric abnormalities.The level of ALT and TBA in pregnancy chronic hepatitis B were significantly higher than those of pregnancy hepatitis without obvious pathogen(P<0.05).Conclusion Hepatitis during pregnancy was always accompanied with abnormal TBA.The lower neonatal Apgar score was associated with TBA abnormality and degree of liver injury,but sometimes it can be inferred from obstetric abnormalities.The maternal and children's health was mostly affected by chronic hepatitis B.