The domestic and oversea literature on the treatment of hepatic encephalopathy (HE) and minimal hepatic encephalopathy (MHE) with L-ornitine-L-aspartate between 2000 and 2010 were searched and summarized.The results showed that mechanism of the therapy was direct reduction of blood ammonia level.The efficacy and safety of L-ornitine-L-aspartate in the treatment of HE was well recognized and its effect on MHE was primarily accepted.
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