Incidence and risk fators of hospital-acquired acute liver injury in ICU

Objective To investigate the incidence and risk factors of the hospital-acquired acute liver injury(HA-ALI) in ICU and analyze the impact of high risk factors on the prognosis of patients with HA-ALI. Methods 127 critically ill patients in general ICU were chosen, who had normal liver function on admission but progressed to acute liver injury (ALI) during hospitalization. All clinical data were analyzed retrospectively. Results Incidence rate of HA-ALI in ICU was 7.83%. Drugs, parenteral nutrition, mechanical ventilation and so on, were the common risk factors. The age was older and serum albumin level was lower in the death group (all P<0.01). Cardiopulmonary resuscitation, shock, and the use of sedatives and narcotic drugs were regarded as the independent risk factors. Conclusion The incidence of HA-ALI was higher in critically ill patients. Some therapeutic measures maybe induce or aggravate ALI. Age, status of liver function ,shock etc, can obviously affect the prognosis of the patients with HA-ALI.