HIV-specific cytotoxic T-lymphocyte responses in patients co-infected with HIV and HCV

Kang WenZhen; Huang DeDong; Li Yuan; Zhuang Yan; Zhai Song; Zhao Ke; Xie YuMei; Sun YongTao

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Jan. 2011

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Article Navigation > Journal of Clinical Hepatology > 2011 > 27(1): 68-71+80

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HIV-specific cytotoxic T-lymphocyte responses in patients co-infected with HIV and HCV

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Published Date: 2011-01-20

Abstract

Abstract

Objective To investigate the features of HIV-specific cytotoxic T-lymphocyte (CTL) responses in patients co-infected with HIV and HCV in China.Methods The patients were divided into 2 groups, HIV/HCV co-infected group (n=22) and simply HIV infected group (n=20) .The HIV-1-specific CTL responses were analyzed in an ELISPOT assay by using peptides spanning the entire HIV-1 Clade B consensus sequence.Comparison was made between the difference of HIV specific CTL of HIV/HCV co-infectied group and simply HIV infected group.Results In comparison of the response between HIV/HCV co-infected and simply HIV infected group, the magnitude and frequency of HIV specific CTL was roughly identical with some difference found at single-peptide level.In HIV/HCV co-infected group, the magnitude and frequency of HIV specific CTL in Gag was higher than those in HIV group.There was positive linear correlation between the magnitude and the frequency of HIV specific CTL in the two groups.Gag and Nef were the most frequently targeted proteins.There was no significant correlation between the total responses of HIV specific CTL and CD4+T cell count.Conclusion HIV-1-specifie CTL may play an important role in aggravating HIV in patients with HIV/HCV co-infection.
- HIV,
- hepacivirus,
- acquired immunodeficiency syndrome,
- T-lymphocytes

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[1]Verucchi G, Calza L, Manfredi R, et al.Humanimmunodeficiency virus and hepatitis C virus coinfection:epidemiology, natural history, therapeutic options andclinical management[J].Infection, 2004, 32 (1) :33-46.

[2]Dodig M, Tavill AS.Hepatitis C and humanimmunodeficiency virus coinfections[J].J ClinGastroenterol, 2001, 33 (5) :367-374.

[3]Zhai S, Zhuang Y, Song Y, et al.HIV-1-specific cytotoxicT lymphocyte (CTL) responses against immunodominantoptimal epitopes slow the progression of AIDS inChina[J].Curr HIV Res, 2008, 6 (4) :335-350.

[4]Graham CS, Baden LR, Yu E, et al.Influence of human immunodeficiency virus infection on the course ofhepatitis C virus infection:a meta-analysis[J].Clin InfectDis, 2001, 33 (4) :562-569.

[5]Rotman Y, Liang TJ.Coinfection with hepatitis Cvirus and human immunodeficiency virus:virological, immunological, and clinical outcomes[J].J Virol, 2009, 83 (15) :7366-7374.

[6]Bonacini M, Louie S, Bzowej N, et al.Survival in patientswith HIV infection and viral hepatitis B or C:a cohortstudy[J].AIDS, 2004, 18 (15) :2039-2045.

[7]Lincoln D, Petoumenos K, Dore GJ.HIV/HBV and HIV/HCV coinfection, and outcomes following highly activeantiretroviral therapy[J].HIV Med, 2003, 4 (3) :241-249.

[8]刘静, 姜拥军, 张, 等.HCV-RNA水平对HIV/HCV合并感染者HIV疾病进展影响研究[J].中华微生物学和免疫学杂志, 2008, 28 (6) :503-507.

[9]Fierer DS, Uriel AJ, Carriero DC, et al.Liver fibrosis duringan outbreak of acute hepatitis C virus infection in HIV-infected men:a prospective cohort study[J].J Infect Dis, 2008, 198 (5) :683-686.

[10]Soriano V, Puoti M, Sulkowski M, et al.Care of patientswith hepatitis C and HIV co-infection[J].AIDS, 2004, 18 (1) :1-12.

[11]Addo MM, Yu XG, Rathod A, et al.Comprehensive ep-itope analysis of human immunodeficiency virus type 1 (HIV-1) -specific T-cell responses directed against theentire expressed HIV-1 genome demonstrate broadlydirected responses, but no correlation to viral load[J].JVirol, 2003, 77 (3) :2081-2092.

[12]De Francesco R, Migliaccio G.Challenges and succe-sses in developing new therapies for hepatitis C[J].Nature, 2005, 436 (7053) :953-960.

[13]Meier V, Ramadori G.Hepatitis C virus virology and newtreatment targets[J].Expert Rev Anti Infect Ther, 2009, 7 (3) :329-350.

[14]Morikawa Y, Zhang WH, Hockley DJ, et al.Detection ofa trimeric human immunodeficiency virus type 1 Gagintermediate is dependent on sequences in the matrixprotein, p17[J].J Virol, 1998, 72 (9) :7659-7663.

[15]Kelleher AD, Long C, Holmes EC, et al.Clusteredmutations in HIV-1 gag are consistently required forescape from HLA-B27-restricted cytotoxic T lymphocyteresponses[J].J Exp Med, 2001, 193 (3) :375-386.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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HIV-specific cytotoxic T-lymphocyte responses in patients co-infected with HIV and HCV

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