中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 1
Jan.  2011

New ideas, challenges and strategies about research on hepatitis C vaccine

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  • Published Date: 2011-01-20
  • Hepatitis C virus (HCV) is a major public health problem and a leading cause of chronic liver disease.Unfortunately, there is no vaccine against HCV and the current standard anti-viral therapy is the combination of pegylated IFN-α with ribavirin, which is only effective in 50%-70% of the patients with HCV infection.Great strides have been made over the past decades, and much has been learned about the pathogenesis of hepatitis C, protective immunity against HCV and causes of persistent infection.Neutralizing antibodies and robust T cell responses including both CD4+ and CD8+ have been shown to be related to the clearance of HCV, which have shed lights on the potential success of HCV vaccines.Recently, there are many HCV vaccines under development, including multi-peptides vaccines, DNA vaccines, recombinant multi-epitopes vaccines, dendritic cell vaccines, etc and many of which were tested before entering into clinical trials.After years of HCV research, it is suggested that we should change our ideas in HCV vaccine research from simply prevention to the cooperation of prevention and treatment, which could induce the persistent immune response and virus inhibition.In this review, we discuss the protective host immunity against HCV and the mechanisms of persistent HCV infection, the challenges, new ideas and strategies in HCV vaccine research are also included.

     

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