Changes on the spots mutation of complement receptor type 1 and on erythrocytes immune adhesion function in HBeAg positive hepatitis patients

Objective To study the changes of the spots mutation of complement receptor type 1 (CR1) on erythrocytes nature immune adhesion function (RNIAF) in HBeAg positive patients.Methods A total of 114 HBeAg positive chronic HBV carriers, with normal hepatic function tests and HBV DNA > 106 IU/ml in serum were grouped as immune suppressed.110 cases of hepatogenic jaundice and ALT twice greater than normal level have been divided into groups of immune response.Polymerase chain reaction (PCR) and Hind restriction enzyme digestion have been used to classify genomic density polymorphism of complement receptor type 1 (CR1) on erythrocytes.At the same time, the function of red cells nature immune-adhering tumor cell was examined.Results The ratio of CR1 gene without spots mutation in immune responsive groups was obviously higher than that of immune suppressed group (P < 0.05) .The RNIAF of immune responsive group was significantly lower than the immune suppressed group (P < 0.01) .The RNIAF of immune responsive patients lowered gradually along with the extent of liver damage.Conclusion The CR1 gene spots mutation and RNIAF are related with the development and prognosis of HBeAg positive hepatitis patients with.