Severe hepatitis resulted from inappropriate use of nucleoside drugs

Objective To investigate the clinical manifestation, treatment and prognosis of severe hepatitis resulted from the inappropriate usage of nucleoside drugs.Methods A total of 41 cases of severe hepatitis resulted from the inappropriate usage of nucleoside drugs were detected from 2006 to 2010 (25 cases of hepatitis and 16 cases of liver cirrhosis) .The patients were treated with protecting liver, anti-virus and supportive artificial liver.The value of TBil, Alb, PTA, HBV DNA, common complications and the prognosis were compared.Results The values of Alb, PTA and HBV DNA were found to be lower.Common complications such as water electrolyte imbalance, primary peritonitis and brain disorder were more common.The mortality rate was higher and the prognosis was worse in liver cirrhosis group compared to the hepatitis group.Conclusion Strengthening patient monitoring and follow-up, prescribing highly effective anti viral drugs as soon as possible after the inappropriate usage of nucleoside drugs is important to avoid severe hepatitis.