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Jan.  2010
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Article Navigation >  Journal of Clinical Hepatology  > 2010  >  26(1): 69-71

The effect of ademetionine on patients with drug-induced cholestatic hepatitis

  • Published Date: 2010-01-20
    Abstract
  • Objective To investigate the effect of ademetionine on patients with cholestatic hepatitis induced by drugs.Methods 88 patients with drug induced cholestatic hepatitis were randomly divided into control group (n =42) and treatment group (n=46) .The liver protectant therapy combined with ademetionine 1000 mg in 5% glucose solution of 250 ml were given intravenously per day in treatment group for 4 weeks.The control group received liver protectant therapy only.Results The combined treatment was more effective in the treatment group than the control group after 2 weeks of treatment (P < 0.05) .At the 4th week of treatment there was no significance difference between the two groups (P > 0.05) .However, the recovery rate difference was statistically significant between the two groups (P < 0.05) .Conclusion Ademetionine is effective and safe, in the treatment of patients with drug-induced cholestatic hepatitis, in promoting the liver metabolism and repairing the hepatic cell.

     

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    • References(8)
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    [6]Watson WH, Zhao Y, chawla RK.S-adenosylmethionine attenuates the lipopoly saccharide-induced expression of the gene for tumour necrosis factoralpha[J].Biochem J.1999, 342 (1) ∶21-25.
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