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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 1
Jan.  2010
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Detection and dynamic changes of serum Th1/Th2 related cytokines in chronic hepatitis C virus infected patients


  • Published Date: 2010-01-20
  • [1]Cecere A, Marotta F, Vangieri B, et al.Progressive liver injury in chronic hepatitis C infection is related to altered cellular immune re-sponse and to different citokine profile[J].panminerva med2004, 46∶171-187.
    [2]Gajewski TF, Fitch FW.Anti-proliferative effect of IFN-gamma in immune regulation.I.IFN-gamma inhibits the proliferation of Th2but not Th1murine helper T lymphocyte clones[J].J Immunol, 1988, 140 (12) ∶4245-4252.
    [3]Tsai SL, Liaw YF, Chen MH, et al.Detection of type2-like T-helper cells in hepatic C virus infection:implications for hepatitis C virus chronicity[J].Hepatology, 1997, 25∶449-458.
    [4]Modlin RL, Nutman TB.Type2cytokines and negative immune regu-lation in human infections[J].Curr Opin Immunol, 1993, 5 (4) ∶511-517.
    [5]Kantzanou M, Lucas M, Barnes E, et al.Viral escape and T cell ex-haustion in hepatitis C virus infection analysed using Class I peptide tetramers[J].Immunol Lett.2003, 85 (2) ∶165-171.
    [6]Mihm S, Schweyer S, Ramadori G.Expression of the chemokine IP-10correlates with the accumulation of hepatic IFN-gamma and IL-18mRNA in chronic hepatitis C but not in hepatitis B[J].J Med Virol, 2003, 70 (4) ∶562-570.
    [7]Yoshioka M, Ito T, Miyazaki S, et al.The release of tumor necrosis factor-alpha, interleukin-1, interleukin-6and prostaglandin E2in bovine Kupffer cells stimulated with bacterial lipopolysaccharide[J].Vet Immunol Immunopathol, 1998, 66 (3-4) ∶301-307.
    [8]Lee CH, Choi YH, Yang SH, et al.Hepatitis C virus core protein in-hibits interleukin12and nitric oxide production from activated macro-phages[J].Virology, 2001, 279 (1) ∶271-279.
    [9]Dolganiuc A, Chang S, Kodys K, et al.Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV in-fection[J].J Immunol, 2006, 177 (10) ∶6758-6768.
    [10]Cook DN, Prosser DM, Forster R, et al.CCR6mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue[J].Immunity, 2000, 12 (5) ∶495-503.
    [11]Katayama K, Kasahara A, Sasaki Y, et al.Immunological response to interferon-gamma priming prior to interferon-alpha treatment in refractory chronic hepatitis C in relation to viral clearance[J].J Vi-ral Hepat, 2001, 8 (3) ∶180-185.
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    [13]Barth H, Klein R, Berg PA, et al.Analysis of the effect of IL-12therapy on immunoregulatory T-cell subsets in patients with chronic hepatitis C infection[J].Hepatogastroenterology, 2003, 50 (49) ∶201-206.
    [14]Asadullah K, Sterry W, Volk HD.Interleukin-10therapy--re-view of a new approach[J].Pharmacol Rev, 2003, 55 (2) ∶241-269.
    [15]Louis H, Le Moine O, Goldman M, et al.Modulation of liver inju-ry by interleukin-10[J].Acta Gastroenterol Belg, 2003, 66 (1) ∶7-14.
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