丙型肝炎病毒感染者的血清甘露聚糖结合凝集素分析

Objective To analyze serum mannan-binding lectin levels in hepatitis C virus-infected subjects, and to explore clinical significance of the levels of mannan-binding lectin for hepatitis C virus-infected subjects.This study will also investigate the relationship between fthe level of mannan-binding lectin and the severity of hepatitis.Methods Peripheral blood samples were obtained from 128 hepatitis C virus-infected subjects.These subjects were divided into three groups, hepatitis C virus carriers, patients with mild chronic hepatitis C and patients with moderate chronic hepatitis C.The concentration of serum mannan-binding lectin was determined using enzyme-linked immunosorbent assay.Results The mean serum concentration of mannan-binding lectin in hepatitis C virus-infected subjects was 1.729±0.529μg/ml.That in healthy controls was 0.974±0.305μg/ml.There were significant differences in the value of serum mannan-binding lectin between hepatitis C virus-infected subjects and healthy controls (P<0.01) .The serum concentration of mannan-binding lectin was associated with the severity of liver damage.Conclusion As an acute phase protein, the serum levels of mannan-binding lectin may relate to chronic liver damage caused by hepatitis virus, It also has a role in the development of fibrosis in hepatitis C virus-infected patients.